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The map label for this gene is rnb

Identifier: 126208235

GI number: 126208235

Start: 866787

End: 868763

Strand: Direct

Name: rnb

Synonym: APL_0757

Alternate gene names: 126208235

Gene position: 866787-868763 (Clockwise)

Preceding gene: 126208234

Following gene: 126208236

Centisome position: 38.11

GC content: 43.75

Gene sequence:

>1977_bases
ATGTTTCAAAACAATCCGTTACTTGCCCAATTAAAGCAACAAATTGAGGCAAATAAAGAATATGTGGAAGGTACGGTTAA
AGCTTCTGATAAAGCGTTCGGTTTTTTAGAATGTGACAAAAAAAGTTATTTCATTCCGCCGATGGAAATGAAAAAAGTGA
TGCACGGCGATAAAGTAAAAGCGGTAGTAAAACGTGAAGACGACAAAGAACAAGTAGAAATCGACAGCTTACTTGAGCCG
ATGCTTGATCGCTTTATTGCACAGGTGCGTTTTAACAAAGACAATAAATTACAACTTATTGTCGATCATCCAAGCATTAA
AAATATCATTCCGGCTAATACGCATAAAAAAGTCACTGAAACATTGGAAAGCGGTGACTGGGTTGTGGCACAGCTTAAAA
CTCACCCGTTACGTGACGATCGTTTCTTATTTGCTCAAGTCACGCAATTTATCTGTAAAGCGGACGATAATTTTGCACCG
TGGTGGGTGACGTTAGCGCGTCACGAGCAACCTCGTGAGCCGGTAGCGAATGAGAAAAGCTATGAATTACACGATGAATT
AGATCGTGAAGATCTGACTTCGCTCTACTTTACCACTATCGATAGCCCTAGCACGCAAGATATGGACGATGCGTTATACA
TTGAGCCAATCAAACAAGGCGAAGTACAAACCGGTTGGCGTTTAGTGGTGGCGATTGCCGATCCGACCGCCTATATTCCG
GAAAACTCAAATCTTGAAAAAGCCGCTCGCCAACGTTGTTTTACCAACTATTTACCGGGCTTCAATATTCCGATGTTGCC
TCGTGAGCTGTCGGATGATCTCTGTTCGCTTGTACCAAATAAAAAACGTCCGGCATTAGTCGGTTATATCGAAACGGATT
TAGCCGGTAATATTACTGGCGACACTCGCTTCGTTTCAGCGTGGGTGGAAAGCAAAGCGAAATTAGCTTATGACAACGTA
TCGGATTATCTCGAACAAGTTGAAAATGCGTGGCAGCCGGAAAGTGCGGAAACCAAACAACAAATCGATTGGTTACACCA
ATTTACCCTTGCTCGCATTGAATGGCGTCGCAACAATGCACTGCTGTTTAAAGAATCCGGCGATTACTCGTTTGAATTGA
ATGAAGACGGTTCGGTGCGCGATATCCACGTGGAATACCGCCGTATCGCAAATCAAATGATCGAAGAATCGATGATCATT
GCCAATATTTGCTGTGCGAAATTCTTAGCGGACAATGCCAAAACAGGCGTATTTAATACCCACGCCGGCTTTGATCCTAA
AAATTTAGAATTAGCGCAAAAATTCTTACTGGATACGTTATCCACTGACGAGAACCGTGATGCACTTACCGCATTCTATG
CGCCGGAAAAACTGGCAACGCTTGAAGGCTATTGTGAAATGCGTCGTTCGATTGACGAGTTTCCGGAGAAATTCTTAGAA
CTTCGCTTACGCCGTTATCTCACTTTTGCAGAGTTTAAATCGGAAGTTGCACCGCATCTCGGTTTAGGGATCAGCCATTA
TGCAACTTGGACATCACCAATTCGTAAGTACGGCGATATGGTAAACCATCGCTTAATCAAGCAAGTATTACTCGGCAAGC
AGGCGAAAACGGTGGAAGAAGGCATCTTAGTTCGCTTACAAGAAGCTCGCCGTCAAAACCGTTTGGTGGAACGTGATATC
GCCGATTGGCTCTATGCACGTTACCTGTTCCCGATGGTAGAACAAGCGGTCGAATTTGACTGTGAAATTGCCGATGTTTC
TCGCGGCGGTGTACGAGCGAAAGTAATCGCAAACGGCGCACAAATTTTCGTGCCGTTCTCCACCCTTCACGATAAAAAAG
AAGAAATGGAATTCCGTCCGGAAGAAATCGCACTGTATATTAAAGGCGAAAAAGCTTACCAAATCGGACAGGCAGTTAAA
GTCAAACTCACCGAAGTACGTTTAGAAACACGTTCGATTGTGGGGAACATTATCTAA

Upstream 100 bases:

>100_bases
TACAAAAAATTCAGCAAATCTAACCGCTTTCCGTTATAATCCCTATCAAATTTCATGGTGCAACGATACTGCACCTTTTT
TATTTTTATAGAGAGAATTT

Downstream 100 bases:

>100_bases
TCGGCAAGCGGTCAAATTTCGAGAATTTTTTGCAAAATTTCCTACAAATTTGACCGCTTATCACATGAGGCTTTATGCAA
AAGAACATTATCGGCTTTGC

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MFQNNPLLAQLKQQIEANKEYVEGTVKASDKAFGFLECDKKSYFIPPMEMKKVMHGDKVKAVVKREDDKEQVEIDSLLEP
MLDRFIAQVRFNKDNKLQLIVDHPSIKNIIPANTHKKVTETLESGDWVVAQLKTHPLRDDRFLFAQVTQFICKADDNFAP
WWVTLARHEQPREPVANEKSYELHDELDREDLTSLYFTTIDSPSTQDMDDALYIEPIKQGEVQTGWRLVVAIADPTAYIP
ENSNLEKAARQRCFTNYLPGFNIPMLPRELSDDLCSLVPNKKRPALVGYIETDLAGNITGDTRFVSAWVESKAKLAYDNV
SDYLEQVENAWQPESAETKQQIDWLHQFTLARIEWRRNNALLFKESGDYSFELNEDGSVRDIHVEYRRIANQMIEESMII
ANICCAKFLADNAKTGVFNTHAGFDPKNLELAQKFLLDTLSTDENRDALTAFYAPEKLATLEGYCEMRRSIDEFPEKFLE
LRLRRYLTFAEFKSEVAPHLGLGISHYATWTSPIRKYGDMVNHRLIKQVLLGKQAKTVEEGILVRLQEARRQNRLVERDI
ADWLYARYLFPMVEQAVEFDCEIADVSRGGVRAKVIANGAQIFVPFSTLHDKKEEMEFRPEEIALYIKGEKAYQIGQAVK
VKLTEVRLETRSIVGNII

Sequences:

>Translated_658_residues
MFQNNPLLAQLKQQIEANKEYVEGTVKASDKAFGFLECDKKSYFIPPMEMKKVMHGDKVKAVVKREDDKEQVEIDSLLEP
MLDRFIAQVRFNKDNKLQLIVDHPSIKNIIPANTHKKVTETLESGDWVVAQLKTHPLRDDRFLFAQVTQFICKADDNFAP
WWVTLARHEQPREPVANEKSYELHDELDREDLTSLYFTTIDSPSTQDMDDALYIEPIKQGEVQTGWRLVVAIADPTAYIP
ENSNLEKAARQRCFTNYLPGFNIPMLPRELSDDLCSLVPNKKRPALVGYIETDLAGNITGDTRFVSAWVESKAKLAYDNV
SDYLEQVENAWQPESAETKQQIDWLHQFTLARIEWRRNNALLFKESGDYSFELNEDGSVRDIHVEYRRIANQMIEESMII
ANICCAKFLADNAKTGVFNTHAGFDPKNLELAQKFLLDTLSTDENRDALTAFYAPEKLATLEGYCEMRRSIDEFPEKFLE
LRLRRYLTFAEFKSEVAPHLGLGISHYATWTSPIRKYGDMVNHRLIKQVLLGKQAKTVEEGILVRLQEARRQNRLVERDI
ADWLYARYLFPMVEQAVEFDCEIADVSRGGVRAKVIANGAQIFVPFSTLHDKKEEMEFRPEEIALYIKGEKAYQIGQAVK
VKLTEVRLETRSIVGNII
>Mature_658_residues
MFQNNPLLAQLKQQIEANKEYVEGTVKASDKAFGFLECDKKSYFIPPMEMKKVMHGDKVKAVVKREDDKEQVEIDSLLEP
MLDRFIAQVRFNKDNKLQLIVDHPSIKNIIPANTHKKVTETLESGDWVVAQLKTHPLRDDRFLFAQVTQFICKADDNFAP
WWVTLARHEQPREPVANEKSYELHDELDREDLTSLYFTTIDSPSTQDMDDALYIEPIKQGEVQTGWRLVVAIADPTAYIP
ENSNLEKAARQRCFTNYLPGFNIPMLPRELSDDLCSLVPNKKRPALVGYIETDLAGNITGDTRFVSAWVESKAKLAYDNV
SDYLEQVENAWQPESAETKQQIDWLHQFTLARIEWRRNNALLFKESGDYSFELNEDGSVRDIHVEYRRIANQMIEESMII
ANICCAKFLADNAKTGVFNTHAGFDPKNLELAQKFLLDTLSTDENRDALTAFYAPEKLATLEGYCEMRRSIDEFPEKFLE
LRLRRYLTFAEFKSEVAPHLGLGISHYATWTSPIRKYGDMVNHRLIKQVLLGKQAKTVEEGILVRLQEARRQNRLVERDI
ADWLYARYLFPMVEQAVEFDCEIADVSRGGVRAKVIANGAQIFVPFSTLHDKKEEMEFRPEEIALYIKGEKAYQIGQAVK
VKLTEVRLETRSIVGNII

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI134288890, Length=362, Percent_Identity=27.3480662983425, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI190014623, Length=445, Percent_Identity=25.6179775280899, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI190014625, Length=445, Percent_Identity=25.6179775280899, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI219521928, Length=454, Percent_Identity=24.0088105726872, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI19115966, Length=454, Percent_Identity=24.0088105726872, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI156105695, Length=228, Percent_Identity=25.4385964912281, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI156105693, Length=238, Percent_Identity=25.6302521008403, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1787542, Length=657, Percent_Identity=48.5540334855403, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=678, Percent_Identity=28.1710914454277, Blast_Score=180, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=361, Percent_Identity=27.1468144044321, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI212645896, Length=514, Percent_Identity=24.7081712062257, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324552, Length=344, Percent_Identity=24.7093023255814, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323943, Length=441, Percent_Identity=21.7687074829932, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24649634, Length=352, Percent_Identity=28.125, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24654592, Length=388, Percent_Identity=26.2886597938144, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922976, Length=388, Percent_Identity=26.2886597938144, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24654597, Length=388, Percent_Identity=26.2886597938144, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNB_ACTP2 (A3N0B9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053460.1
- ProteinModelPortal:   A3N0B9
- SMR:   A3N0B9
- STRING:   A3N0B9
- GeneID:   4850359
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0757
- eggNOG:   COG4776
- HOGENOM:   HBG401488
- OMA:   MDDALYI
- PhylomeDB:   A3N0B9
- ProtClustDB:   PRK05054
- BioCyc:   APLE416269:APL_0757-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01036
- InterPro:   IPR011129
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR004476
- InterPro:   IPR011804
- PANTHER:   PTHR23355:SF6
- SMART:   SM00357
- SMART:   SM00955
- SMART:   SM00316
- TIGRFAMs:   TIGR00358
- TIGRFAMs:   TIGR02062

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1

EC number: =3.1.13.1

Molecular weight: Translated: 75768; Mature: 75768

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS01175 RIBONUCLEASE_II; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNNPLLAQLKQQIEANKEYVEGTVKASDKAFGFLECDKKSYFIPPMEMKKVMHGDKVK
CCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHH
AVVKREDDKEQVEIDSLLEPMLDRFIAQVRFNKDNKLQLIVDHPSIKNIIPANTHKKVTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
TLESGDWVVAQLKTHPLRDDRFLFAQVTQFICKADDNFAPWWVTLARHEQPREPVANEKS
HHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
YELHDELDREDLTSLYFTTIDSPSTQDMDDALYIEPIKQGEVQTGWRLVVAIADPTAYIP
CCHHHHCCHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEECC
ENSNLEKAARQRCFTNYLPGFNIPMLPRELSDDLCSLVPNKKRPALVGYIETDLAGNITG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
DTRFVSAWVESKAKLAYDNVSDYLEQVENAWQPESAETKQQIDWLHQFTLARIEWRRNNA
CHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCE
LLFKESGDYSFELNEDGSVRDIHVEYRRIANQMIEESMIIANICCAKFLADNAKTGVFNT
EEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
HAGFDPKNLELAQKFLLDTLSTDENRDALTAFYAPEKLATLEGYCEMRRSIDEFPEKFLE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LRLRRYLTFAEFKSEVAPHLGLGISHYATWTSPIRKYGDMVNHRLIKQVLLGKQAKTVEE
HHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GILVRLQEARRQNRLVERDIADWLYARYLFPMVEQAVEFDCEIADVSRGGVRAKVIANGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCC
QIFVPFSTLHDKKEEMEFRPEEIALYIKGEKAYQIGQAVKVKLTEVRLETRSIVGNII
EEEEEHHHHHCCHHHHCCCCCCEEEEEECCHHHHCCCHHEEEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQNNPLLAQLKQQIEANKEYVEGTVKASDKAFGFLECDKKSYFIPPMEMKKVMHGDKVK
CCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCHHH
AVVKREDDKEQVEIDSLLEPMLDRFIAQVRFNKDNKLQLIVDHPSIKNIIPANTHKKVTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
TLESGDWVVAQLKTHPLRDDRFLFAQVTQFICKADDNFAPWWVTLARHEQPREPVANEKS
HHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCC
YELHDELDREDLTSLYFTTIDSPSTQDMDDALYIEPIKQGEVQTGWRLVVAIADPTAYIP
CCHHHHCCHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEECC
ENSNLEKAARQRCFTNYLPGFNIPMLPRELSDDLCSLVPNKKRPALVGYIETDLAGNITG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
DTRFVSAWVESKAKLAYDNVSDYLEQVENAWQPESAETKQQIDWLHQFTLARIEWRRNNA
CHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEECCCE
LLFKESGDYSFELNEDGSVRDIHVEYRRIANQMIEESMIIANICCAKFLADNAKTGVFNT
EEEEECCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEC
HAGFDPKNLELAQKFLLDTLSTDENRDALTAFYAPEKLATLEGYCEMRRSIDEFPEKFLE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LRLRRYLTFAEFKSEVAPHLGLGISHYATWTSPIRKYGDMVNHRLIKQVLLGKQAKTVEE
HHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GILVRLQEARRQNRLVERDIADWLYARYLFPMVEQAVEFDCEIADVSRGGVRAKVIANGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCC
QIFVPFSTLHDKKEEMEFRPEEIALYIKGEKAYQIGQAVKVKLTEVRLETRSIVGNII
EEEEEHHHHHCCHHHHCCCCCCEEEEEECCHHHHCCCHHEEEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA