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The map label for this gene is lysC [H]

Identifier: 126208190

GI number: 126208190

Start: 820409

End: 821761

Strand: Direct

Name: lysC [H]

Synonym: APL_0710

Alternate gene names: 126208190

Gene position: 820409-821761 (Clockwise)

Preceding gene: 126208189

Following gene: 126208194

Centisome position: 36.07

GC content: 43.46

Gene sequence:

>1353_bases
ATGTCTCATCTTTCGGTTGCAAAATTCGGTGGAACCAGTGTAGCAAATTTCGACGCAATGACATCTTGTGCGAATATCGT
AACATCAGATGCCAATACGCGTGTTGTCGTACTTTCTGCGTCTGCAGGCGTAACTAATTATTTAGTAGAATTAGCGAACG
GTTGTGAAAAAGAACGTCGTGAAGAAATCTTGGATGCGGTACGTACCATTCAATACAACATCATTGAAAAATTACAAAAT
CAAAGTGAAGTTTCCGCTGAAATCGACGAATTATTACAACATATCGCCGCATTAGCGGAATCTGCAAGTCTTGCGACATC
CAACGCTTTAACCGATGAATTAATCTGTCACGGCGAAATGATGTCCACTAAAATTTTTACTCAGTTGCTAAAAGAACGTA
ATTTCCCGGCAGTATGGGTAGATGTGCGTGACATTGTCGCGACAAATAGCAATTATGGCAAAGCCGCACCAAATGACGAA
AAAACGCAACAGCAATCCGATGCGATTATTAAACCGCTAATTGCAGCAGGTAATGTCGTGATTACTCAAGGTTTTATCGG
TCGAGATGATGAGGGTAAAACGACCACTTTAGGTCGTGGCGGCTCGGATTACTCTGCGGCATTATTAGCGGAAGTGCTAA
ATGCGAATGACGTATTAATTTGGACGGACGTACCGGGTATTTATACAACCGATCCGCGTGTCGTACCAAATGCACAGCGT
ATTGATACCATGGCATTTAACGAAGCGGCGGAAATGGCGACTTTCGGTGCAAAAGTGCTACACCCTGCAACTTTATTACC
TGCCGTACGCAGTAACATTCCTGTTTATGTCGGCTCAAGCAAAGCACCGGAACAAGGCGGTACTTGGGTAACGCGTGATC
CGCAACCGCGCCCGACGTTCCGTGCAATTGCGTTACGTCGTAACCAAACATTATTAACGCTATCCAGCCTTTCAATGCTT
CACGCGCAAGGCTTTTTAGCTAACGTATTCGCTATTCTGGCAAAACACAAAATTTCGGTAGATGTAATTACTACATCGGA
AGTCAGCGTAGCATTAACTTTGGATAAAACCGGTTCGGCATCATCCGGTGCGGATATGTTATCAAAAGAATTACTGGACG
AATTAAACGCTTATTGCCACGTACAAGTGGAACACGATTTAGCGTTAATCGCAATTATCGGTAATAATTTACATACGCAA
GCCGGTGTGGCTAAACAGTTATTCCATACGATTGAGAATTTCAATATTCGCTTAATTAGCTACGGCGCAAGCACAAACAA
CGTTTGTACGCTTATTAAAAATGACGAAGCGGACGAAGTGGTTCGCGCACTTCACGCCGGACTATTTGAATAA

Upstream 100 bases:

>100_bases
TAATTGGTTCTTAAATCAAACCGCCTAATCTACTCAATTTCCTTTCGAATATCCACTACACATATCATCTATTATTTTTG
ATTTATAGGAAATTCTTATT

Downstream 100 bases:

>100_bases
ACGTAAACTCCAAATATAAACAAGCGGTTGATTTTTGTAAAAATTTAACAAAAATCAACCGCTTGCATTTCGATAGAAGC
GCTAAAAGAGACGACTAAAA

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSHLSVAKFGGTSVANFDAMTSCANIVTSDANTRVVVLSASAGVTNYLVELANGCEKERREEILDAVRTIQYNIIEKLQN
QSEVSAEIDELLQHIAALAESASLATSNALTDELICHGEMMSTKIFTQLLKERNFPAVWVDVRDIVATNSNYGKAAPNDE
KTQQQSDAIIKPLIAAGNVVITQGFIGRDDEGKTTTLGRGGSDYSAALLAEVLNANDVLIWTDVPGIYTTDPRVVPNAQR
IDTMAFNEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEQGGTWVTRDPQPRPTFRAIALRRNQTLLTLSSLSML
HAQGFLANVFAILAKHKISVDVITTSEVSVALTLDKTGSASSGADMLSKELLDELNAYCHVQVEHDLALIAIIGNNLHTQ
AGVAKQLFHTIENFNIRLISYGASTNNVCTLIKNDEADEVVRALHAGLFE

Sequences:

>Translated_450_residues
MSHLSVAKFGGTSVANFDAMTSCANIVTSDANTRVVVLSASAGVTNYLVELANGCEKERREEILDAVRTIQYNIIEKLQN
QSEVSAEIDELLQHIAALAESASLATSNALTDELICHGEMMSTKIFTQLLKERNFPAVWVDVRDIVATNSNYGKAAPNDE
KTQQQSDAIIKPLIAAGNVVITQGFIGRDDEGKTTTLGRGGSDYSAALLAEVLNANDVLIWTDVPGIYTTDPRVVPNAQR
IDTMAFNEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEQGGTWVTRDPQPRPTFRAIALRRNQTLLTLSSLSML
HAQGFLANVFAILAKHKISVDVITTSEVSVALTLDKTGSASSGADMLSKELLDELNAYCHVQVEHDLALIAIIGNNLHTQ
AGVAKQLFHTIENFNIRLISYGASTNNVCTLIKNDEADEVVRALHAGLFE
>Mature_449_residues
SHLSVAKFGGTSVANFDAMTSCANIVTSDANTRVVVLSASAGVTNYLVELANGCEKERREEILDAVRTIQYNIIEKLQNQ
SEVSAEIDELLQHIAALAESASLATSNALTDELICHGEMMSTKIFTQLLKERNFPAVWVDVRDIVATNSNYGKAAPNDEK
TQQQSDAIIKPLIAAGNVVITQGFIGRDDEGKTTTLGRGGSDYSAALLAEVLNANDVLIWTDVPGIYTTDPRVVPNAQRI
DTMAFNEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEQGGTWVTRDPQPRPTFRAIALRRNQTLLTLSSLSMLH
AQGFLANVFAILAKHKISVDVITTSEVSVALTLDKTGSASSGADMLSKELLDELNAYCHVQVEHDLALIAIIGNNLHTQA
GVAKQLFHTIENFNIRLISYGASTNNVCTLIKNDEADEVVRALHAGLFE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=60.8888888888889, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1786183, Length=476, Percent_Identity=31.9327731092437, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1790376, Length=294, Percent_Identity=29.5918367346939, Blast_Score=138, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320893, Length=497, Percent_Identity=26.5593561368209, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48488; Mature: 48357

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHLSVAKFGGTSVANFDAMTSCANIVTSDANTRVVVLSASAGVTNYLVELANGCEKERR
CCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHH
EEILDAVRTIQYNIIEKLQNQSEVSAEIDELLQHIAALAESASLATSNALTDELICHGEM
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
MSTKIFTQLLKERNFPAVWVDVRDIVATNSNYGKAAPNDEKTQQQSDAIIKPLIAAGNVV
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
ITQGFIGRDDEGKTTTLGRGGSDYSAALLAEVLNANDVLIWTDVPGIYTTDPRVVPNAQR
EEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHH
IDTMAFNEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEQGGTWVTRDPQPRPTF
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCCCCCCH
RAIALRRNQTLLTLSSLSMLHAQGFLANVFAILAKHKISVDVITTSEVSVALTLDKTGSA
HHHEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCC
SSGADMLSKELLDELNAYCHVQVEHDLALIAIIGNNLHTQAGVAKQLFHTIENFNIRLIS
CCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
YGASTNNVCTLIKNDEADEVVRALHAGLFE
ECCCCCCEEEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHLSVAKFGGTSVANFDAMTSCANIVTSDANTRVVVLSASAGVTNYLVELANGCEKERR
CCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHHH
EEILDAVRTIQYNIIEKLQNQSEVSAEIDELLQHIAALAESASLATSNALTDELICHGEM
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHH
MSTKIFTQLLKERNFPAVWVDVRDIVATNSNYGKAAPNDEKTQQQSDAIIKPLIAAGNVV
HHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
ITQGFIGRDDEGKTTTLGRGGSDYSAALLAEVLNANDVLIWTDVPGIYTTDPRVVPNAQR
EEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCHHH
IDTMAFNEAAEMATFGAKVLHPATLLPAVRSNIPVYVGSSKAPEQGGTWVTRDPQPRPTF
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCCCCCCH
RAIALRRNQTLLTLSSLSMLHAQGFLANVFAILAKHKISVDVITTSEVSVALTLDKTGSA
HHHEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCC
SSGADMLSKELLDELNAYCHVQVEHDLALIAIIGNNLHTQAGVAKQLFHTIENFNIRLIS
CCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
YGASTNNVCTLIKNDEADEVVRALHAGLFE
ECCCCCCEEEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]