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The map label for this gene is dld [H]

Identifier: 126208167

GI number: 126208167

Start: 785117

End: 786808

Strand: Direct

Name: dld [H]

Synonym: APL_0687

Alternate gene names: 126208167

Gene position: 785117-786808 (Clockwise)

Preceding gene: 126208159

Following gene: 126208170

Centisome position: 34.52

GC content: 42.49

Gene sequence:

>1692_bases
ATGTCTGCACATTTACTGATTCCACAACTGACCGAAATCGTTGGTTCTCAACACATTATTACCGATGCGGCTAAAAGCGA
AGCTTATCGTAGCGGCTATCGTTTCGGGACGGGAAAAGCACTTGCCGTGGTGCGCCCTGCAACATTATTAGAATATTGGC
GAGTTTTAAAAGCCTGTGTACGTCACGATGTCATTGTGATTAACCAAGCTGCCAATACCGGCTTGACTGGTGGCTCGACC
CCGAACGGCAATGATTACGACCGAGAAATTGTCATTATCAATACGATGAGAATGGACGGTATCCAGTTGATCAACAATGC
GGAACAAGTGGTCTGTTTACCGGGTTCGACACTCAATGAGTTAGAAATTAAACTTAAACCGCACGGACGTGAACCTCACT
CTGTTATCGGCTCATCTTGTATCGGTGCTTCGGTGATTGGTGGTGTGTGTAATAACTCCGGCGGTGCATTGGTACAACGA
GGCCCGGCTTATACCGAAATGGCGTTATTTGCTCAACTAAACGAACAAGGCGAGCTTGAGCTTAAAAATCACTTAGGCAT
TGATTTAGGCGAAACGCCGGAAGAAATTTTAGAAAATCTGCAAAATAATCGCTATCAACGCAAAGATATTCAACTAGATT
GCGGTAAAGGTCATGATCATACTTATTGTGATCACGTGCGTAAAATTGATGAAGACTCCCCTGCTCGCTTTAATGCCGAT
CCGAATCGCCATTATGAAGCCTCCGGTAGTGCCGGTAAATTAGCCGTGTTTGCTGTGCGTTTAGATACTTTCCCGTTAGA
AAAGCAAACCGCCGTGTTCTATATAGGTACAAATCACACCGCTACCCTAAACGATTTACGCCGTCATATGCTTGCCAACT
TTAAGCAATTACCGATTTCCGGTGAATATATTCATCGTGATGCGTTCGATATTGCCGCGCGTTACGGTAAAGATACGTTC
TGGGTCATTAAAAAATTCGGTACGCACTGGTTACCGAAATTATTCGCCTTAAAAGCCAATGCCGACCGTATTGCGAAAAA
ATTCTCGTTCTTACCTCATCATTTAAGCGATAAATTTATGCAGACATTATCTAAACGTTTACCGGAACATTTACCGCAAA
GTTTATGGCAATATCGTGAAAAGTATGAACACCATTTAATTCTGAAAATGGGCGGAACCGGCGTTGCCGAGGCTCGTGAA
TATTTAAAACAATATTTTTCCGAAAGCGAGAAAGGCGGTTATTTCGAATGTAATGCGGTGGAAACACAAGCGGCAATGTT
ACACCGTTTTGCAGTAGCCTCTGCCGCAATTCGTTATCGAGCTACACACGAAAATGAGGTGGAAGATATTGTTGCATTAG
ATATTGCATTACGTCGTAATGATCAAGATTGGTTTGAGGTCTTACCGCCTGAAATCGATCAGAAAATCCTGCATAAACTC
TATTACGGACATTTTATGTGCCACGTATTCCACCAAGACTACATTGTGAAAAAAGGCGTAGATTGTGTTGCGTTAGAACA
CGAAATGTTAGCCTTATTAGATAAACGTGGTGCACAATACCCTGCGGAACATAACGTCGGGCATTTATATGAAGCAAAAC
CGACGTTACGCAAATTCTATAAAGATTTAGATCCAACCAATAGCTTTAACGTAGGTATCGGACAAACTTCTAAGAAAAAA
TACTGGAAATAG

Upstream 100 bases:

>100_bases
TTCTCCTTAAAAAAATAATGCTAAATATAGCATAAAATTTATTACACATTTAGCCATCTTTTGTTATGATTTTGTTAATT
TTATACTAAGGAGGCTTATC

Downstream 100 bases:

>100_bases
TATAATAAAGCTGTCTATTTTTGCTTTTCCTTTGCAAGAAAATTAAAAAAATAACCGCTTGTCATTCAGTTAATATAAAT
ATAAAAACGCACTAAAGCCC

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSAHLLIPQLTEIVGSQHIITDAAKSEAYRSGYRFGTGKALAVVRPATLLEYWRVLKACVRHDVIVINQAANTGLTGGST
PNGNDYDREIVIINTMRMDGIQLINNAEQVVCLPGSTLNELEIKLKPHGREPHSVIGSSCIGASVIGGVCNNSGGALVQR
GPAYTEMALFAQLNEQGELELKNHLGIDLGETPEEILENLQNNRYQRKDIQLDCGKGHDHTYCDHVRKIDEDSPARFNAD
PNRHYEASGSAGKLAVFAVRLDTFPLEKQTAVFYIGTNHTATLNDLRRHMLANFKQLPISGEYIHRDAFDIAARYGKDTF
WVIKKFGTHWLPKLFALKANADRIAKKFSFLPHHLSDKFMQTLSKRLPEHLPQSLWQYREKYEHHLILKMGGTGVAEARE
YLKQYFSESEKGGYFECNAVETQAAMLHRFAVASAAIRYRATHENEVEDIVALDIALRRNDQDWFEVLPPEIDQKILHKL
YYGHFMCHVFHQDYIVKKGVDCVALEHEMLALLDKRGAQYPAEHNVGHLYEAKPTLRKFYKDLDPTNSFNVGIGQTSKKK
YWK

Sequences:

>Translated_563_residues
MSAHLLIPQLTEIVGSQHIITDAAKSEAYRSGYRFGTGKALAVVRPATLLEYWRVLKACVRHDVIVINQAANTGLTGGST
PNGNDYDREIVIINTMRMDGIQLINNAEQVVCLPGSTLNELEIKLKPHGREPHSVIGSSCIGASVIGGVCNNSGGALVQR
GPAYTEMALFAQLNEQGELELKNHLGIDLGETPEEILENLQNNRYQRKDIQLDCGKGHDHTYCDHVRKIDEDSPARFNAD
PNRHYEASGSAGKLAVFAVRLDTFPLEKQTAVFYIGTNHTATLNDLRRHMLANFKQLPISGEYIHRDAFDIAARYGKDTF
WVIKKFGTHWLPKLFALKANADRIAKKFSFLPHHLSDKFMQTLSKRLPEHLPQSLWQYREKYEHHLILKMGGTGVAEARE
YLKQYFSESEKGGYFECNAVETQAAMLHRFAVASAAIRYRATHENEVEDIVALDIALRRNDQDWFEVLPPEIDQKILHKL
YYGHFMCHVFHQDYIVKKGVDCVALEHEMLALLDKRGAQYPAEHNVGHLYEAKPTLRKFYKDLDPTNSFNVGIGQTSKKK
YWK
>Mature_562_residues
SAHLLIPQLTEIVGSQHIITDAAKSEAYRSGYRFGTGKALAVVRPATLLEYWRVLKACVRHDVIVINQAANTGLTGGSTP
NGNDYDREIVIINTMRMDGIQLINNAEQVVCLPGSTLNELEIKLKPHGREPHSVIGSSCIGASVIGGVCNNSGGALVQRG
PAYTEMALFAQLNEQGELELKNHLGIDLGETPEEILENLQNNRYQRKDIQLDCGKGHDHTYCDHVRKIDEDSPARFNADP
NRHYEASGSAGKLAVFAVRLDTFPLEKQTAVFYIGTNHTATLNDLRRHMLANFKQLPISGEYIHRDAFDIAARYGKDTFW
VIKKFGTHWLPKLFALKANADRIAKKFSFLPHHLSDKFMQTLSKRLPEHLPQSLWQYREKYEHHLILKMGGTGVAEAREY
LKQYFSESEKGGYFECNAVETQAAMLHRFAVASAAIRYRATHENEVEDIVALDIALRRNDQDWFEVLPPEIDQKILHKLY
YGHFMCHVFHQDYIVKKGVDCVALEHEMLALLDKRGAQYPAEHNVGHLYEAKPTLRKFYKDLDPTNSFNVGIGQTSKKKY
WK

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=558, Percent_Identity=61.4695340501792, Blast_Score=722, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 63739; Mature: 63608

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHLLIPQLTEIVGSQHIITDAAKSEAYRSGYRFGTGKALAVVRPATLLEYWRVLKACV
CCCCEEHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
RHDVIVINQAANTGLTGGSTPNGNDYDREIVIINTMRMDGIQLINNAEQVVCLPGSTLNE
HCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHCCCCEEEECCCCCCCE
LEIKLKPHGREPHSVIGSSCIGASVIGGVCNNSGGALVQRGPAYTEMALFAQLNEQGELE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCEE
LKNHLGIDLGETPEEILENLQNNRYQRKDIQLDCGKGHDHTYCDHVRKIDEDSPARFNAD
EHHCCCCCCCCCHHHHHHHHHCCCEECCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCCC
PNRHYEASGSAGKLAVFAVRLDTFPLEKQTAVFYIGTNHTATLNDLRRHMLANFKQLPIS
CCCCEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
GEYIHRDAFDIAARYGKDTFWVIKKFGTHWLPKLFALKANADRIAKKFSFLPHHLSDKFM
CCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHHHEECCHHHHHHHHHHCCHHHHHHHH
QTLSKRLPEHLPQSLWQYREKYEHHLILKMGGTGVAEAREYLKQYFSESEKGGYFECNAV
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRATHENEVEDIVALDIALRRNDQDWFEVLPPEIDQKILHKL
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHEECCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGVDCVALEHEMLALLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KDLDPTNSFNVGIGQTSKKKYWK
HHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAHLLIPQLTEIVGSQHIITDAAKSEAYRSGYRFGTGKALAVVRPATLLEYWRVLKACV
CCCEEHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
RHDVIVINQAANTGLTGGSTPNGNDYDREIVIINTMRMDGIQLINNAEQVVCLPGSTLNE
HCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHCCCCEEEECCCCCCCE
LEIKLKPHGREPHSVIGSSCIGASVIGGVCNNSGGALVQRGPAYTEMALFAQLNEQGELE
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCCEE
LKNHLGIDLGETPEEILENLQNNRYQRKDIQLDCGKGHDHTYCDHVRKIDEDSPARFNAD
EHHCCCCCCCCCHHHHHHHHHCCCEECCCCEEECCCCCCCHHHHHHHHCCCCCCCCCCCC
PNRHYEASGSAGKLAVFAVRLDTFPLEKQTAVFYIGTNHTATLNDLRRHMLANFKQLPIS
CCCCEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
GEYIHRDAFDIAARYGKDTFWVIKKFGTHWLPKLFALKANADRIAKKFSFLPHHLSDKFM
CCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHHHEECCHHHHHHHHHHCCHHHHHHHH
QTLSKRLPEHLPQSLWQYREKYEHHLILKMGGTGVAEAREYLKQYFSESEKGGYFECNAV
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCH
ETQAAMLHRFAVASAAIRYRATHENEVEDIVALDIALRRNDQDWFEVLPPEIDQKILHKL
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHEECCCCHHHHCCCCHHHHHHHHHH
YYGHFMCHVFHQDYIVKKGVDCVALEHEMLALLDKRGAQYPAEHNVGHLYEAKPTLRKFY
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHH
KDLDPTNSFNVGIGQTSKKKYWK
HHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]