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The map label for this gene is moaA

Identifier: 126208170

GI number: 126208170

Start: 791084

End: 792106

Strand: Direct

Name: moaA

Synonym: APL_0690

Alternate gene names: 126208170

Gene position: 791084-792106 (Clockwise)

Preceding gene: 126208167

Following gene: 126208171

Centisome position: 34.78

GC content: 43.7

Gene sequence:

>1023_bases
ATGCAATCCATTCCAATTAAACATGTTGGGGCGGATAATGTTTCTCAGCTTATTGATCGCTTTGAACGACAATATGTTTA
TTTACGTTTATCCGTTACCGATGTCTGCAATTTTCGCTGTAATTATTGTCTGCCGGACGGCTATAAGCCTCCTTCACATA
GGCAGCAATTTTTAAGCATATCCGAAATTCAACGTGTCGTGCGTGCTTTTGCTGATCTCGGCACGGAAAAAGTGCGCATT
ACCGGTGGCGAACCGACTTTACGTAAAGATTTTTTAGAAATTGCGCATACCGTTTCGCAAACGAACGGCATTAAAAAAGT
AGCTTTGACTACTAACGGTTATCGTATGGAACGCGATATCGATTTATGGCAACAAGCCGGTATTACCGATATTAACGTTA
GCGTAGATAGCTTAGATACACGCCAATTCCAGCTAATCACCGGTGAAAATAAGCTGCAATCGATCCTAAAAGGCATTGAT
AGAGCGTTTGAAATCGGCTATCGCAAAATCAAAGTGAATGCGGTGTTAATGAAGCAATACACCGCCCCCGAATTAGATAA
ATTCCTCGCTTGGATTAAAGATAAACCGATTCAAATGCGTTTTATTGAGCTAATGGAAACCGGTGAAATGGACAGTTTTT
TCAAAGCACAACATTTATCCGGTCAGTCGGTAATGCAACGCTTGTTACAAGAAGGCTGGCAATTACAGCCAAAAGCGTTA
TCGGACGGCCCGGCGAAAGTGCTTTCACACCCTGATTACCAAGGCGAAATCGGTTTGATTATGCCGTATGAGAAAAACTT
CTGCGCCAGCTGCAACCGCCTGCGTGTTTCGGCACTCGGCAAATTGCACCTTTGCTTATTCGGCGAGGAAGGCATTGATT
TGCGAGATTTACTCTCGGAAGATACCCAACAAGCGCAATTGAAAGCACGCTTAAAAGCCGCATTACAAGGTAAACGGGAA
CATCACTATTTGCATATCGGTGATAGCGGGATTCGAAATAACCTCGCCTCAATCGGCGGCTAA

Upstream 100 bases:

>100_bases
TGTAAGAATATGGTAGCAATGCCTGTAATTAGCTTATACGTAGCTGATTCAAGGGAATTTCAAGAAATTGTTGTTCCTCT
CGTGTTTAGAAAGGTGTCCA

Downstream 100 bases:

>100_bases
ATTACAAAAATCTGACGAAAAGAGACCGCTTGATCGGGTTCCCTTCTGAGCCGCCTGAACGTGTTGGATATTTGTAGGAA
CATTTTTCTTGAGCGTAGCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQSIPIKHVGADNVSQLIDRFERQYVYLRLSVTDVCNFRCNYCLPDGYKPPSHRQQFLSISEIQRVVRAFADLGTEKVRI
TGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDIDLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGID
RAFEIGYRKIKVNAVLMKQYTAPELDKFLAWIKDKPIQMRFIELMETGEMDSFFKAQHLSGQSVMQRLLQEGWQLQPKAL
SDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSEDTQQAQLKARLKAALQGKRE
HHYLHIGDSGIRNNLASIGG

Sequences:

>Translated_340_residues
MQSIPIKHVGADNVSQLIDRFERQYVYLRLSVTDVCNFRCNYCLPDGYKPPSHRQQFLSISEIQRVVRAFADLGTEKVRI
TGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDIDLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGID
RAFEIGYRKIKVNAVLMKQYTAPELDKFLAWIKDKPIQMRFIELMETGEMDSFFKAQHLSGQSVMQRLLQEGWQLQPKAL
SDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSEDTQQAQLKARLKAALQGKRE
HHYLHIGDSGIRNNLASIGG
>Mature_340_residues
MQSIPIKHVGADNVSQLIDRFERQYVYLRLSVTDVCNFRCNYCLPDGYKPPSHRQQFLSISEIQRVVRAFADLGTEKVRI
TGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDIDLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGID
RAFEIGYRKIKVNAVLMKQYTAPELDKFLAWIKDKPIQMRFIELMETGEMDSFFKAQHLSGQSVMQRLLQEGWQLQPKAL
SDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSEDTQQAQLKARLKAALQGKRE
HHYLHIGDSGIRNNLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=34.5565749235474, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=34.5565749235474, Blast_Score=208, Evalue=7e-54,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=60.3658536585366, Blast_Score=433, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566331, Length=309, Percent_Identity=37.5404530744337, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=309, Percent_Identity=37.5404530744337, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17561210, Length=310, Percent_Identity=36.7741935483871, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574490, Length=334, Percent_Identity=35.0299401197605, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI28574488, Length=341, Percent_Identity=34.8973607038123, Blast_Score=214, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_ACTP2 (A3N054)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053395.1
- ProteinModelPortal:   A3N054
- SMR:   A3N054
- STRING:   A3N054
- GeneID:   4848653
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0690
- eggNOG:   COG2896
- HOGENOM:   HBG529885
- OMA:   NAVLMKQ
- PhylomeDB:   A3N054
- ProtClustDB:   PRK00164
- BioCyc:   APLE416269:APL_0690-MONOMER
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 38611; Mature: 38611

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 29-29 BINDING 42-42 BINDING 79-79 BINDING 83-83 BINDING 110-110 BINDING 134-134 BINDING 171-171 BINDING 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIPIKHVGADNVSQLIDRFERQYVYLRLSVTDVCNFRCNYCLPDGYKPPSHRQQFLSI
CCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SEIQRVVRAFADLGTEKVRITGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDI
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCH
DLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGIDRAFEIGYRKIKVNAVLMKQY
HHHHHCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECC
TAPELDKFLAWIKDKPIQMRFIELMETGEMDSFFKAQHLSGQSVMQRLLQEGWQLQPKAL
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
SDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSE
CCCCHHHHCCCCCCCCEEEEECCCCCHHHCCCCEEHHHCCEEEEEEECCCCCCHHHHHCC
DTQQAQLKARLKAALQGKREHHYLHIGDSGIRNNLASIGG
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCC
>Mature Secondary Structure
MQSIPIKHVGADNVSQLIDRFERQYVYLRLSVTDVCNFRCNYCLPDGYKPPSHRQQFLSI
CCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
SEIQRVVRAFADLGTEKVRITGGEPTLRKDFLEIAHTVSQTNGIKKVALTTNGYRMERDI
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCH
DLWQQAGITDINVSVDSLDTRQFQLITGENKLQSILKGIDRAFEIGYRKIKVNAVLMKQY
HHHHHCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECC
TAPELDKFLAWIKDKPIQMRFIELMETGEMDSFFKAQHLSGQSVMQRLLQEGWQLQPKAL
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
SDGPAKVLSHPDYQGEIGLIMPYEKNFCASCNRLRVSALGKLHLCLFGEEGIDLRDLLSE
CCCCHHHHCCCCCCCCEEEEECCCCCHHHCCCCEEHHHCCEEEEEEECCCCCCHHHHHCC
DTQQAQLKARLKAALQGKREHHYLHIGDSGIRNNLASIGG
HHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA