Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 126208139

GI number: 126208139

Start: 752887

End: 753381

Strand: Direct

Name: purE [H]

Synonym: APL_0659

Alternate gene names: 126208139

Gene position: 752887-753381 (Clockwise)

Preceding gene: 126208136

Following gene: 126208140

Centisome position: 33.1

GC content: 46.06

Gene sequence:

>495_bases
ATGTCTGAAAAACCTGAAATTGCAATTGTTATGGGTTCAAAAAGCGACTGGGCGACCATGTCGGAAGCAACACAAATCTT
AGATCAGTTTAATCTTGCTTATCACGTTGAAGTGGTTTCGGCACACCGTACGCCGGACAAACTTTTCTCATTTGCGGAAA
GTGCGGAACAAAACGGTTATAAAGTGATTATCGCAGGGGCAGGCGGTGCGGCGCATTTACCGGGTATGATTGCGGCAAAA
ACCATCGTTCCTGTATTAGGCGTTCCGGTAAAAAGTTCGATGTTAAGCGGTGTAGATAGCTTATACTCTATCGTTCAAAT
GCCTAAGGGTATTCCGGTCGGTACGCTTGCGATTGGCCCTGCGGGTGCGGCGAATGCAGGTTTACTCGCTGCTCAAATTT
TAGCGGCGTTTAACTCTGAGTTAGCTCAAAAGCTACACGCATTCCGCAATGAACAAACGCAATCGGTATTAGATAATCCA
GATCCACGTAACTAA

Upstream 100 bases:

>100_bases
CATTATTTGGTCTGATTCGTCCGTATAAATTCACAAGCAAACGTTTGCCTATTATGTTATACTGAAAAAGTTTTCCCCTC
TTGTTTCAAAAGGAATCAAT

Downstream 100 bases:

>100_bases
TAGATTTTCATGACAAAGAAACTTTTAATCCTACATACGGGCGGTACGATTTCGATGAGTGAAGGCGAAGACGGTAAAGT
TTCGCCTTCCGAAAAGAATC

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSEKPEIAIVMGSKSDWATMSEATQILDQFNLAYHVEVVSAHRTPDKLFSFAESAEQNGYKVIIAGAGGAAHLPGMIAAK
TIVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFNSELAQKLHAFRNEQTQSVLDNP
DPRN

Sequences:

>Translated_164_residues
MSEKPEIAIVMGSKSDWATMSEATQILDQFNLAYHVEVVSAHRTPDKLFSFAESAEQNGYKVIIAGAGGAAHLPGMIAAK
TIVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFNSELAQKLHAFRNEQTQSVLDNP
DPRN
>Mature_163_residues
SEKPEIAIVMGSKSDWATMSEATQILDQFNLAYHVEVVSAHRTPDKLFSFAESAEQNGYKVIIAGAGGAAHLPGMIAAKT
IVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAAFNSELAQKLHAFRNEQTQSVLDNPD
PRN

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=77.2151898734177, Blast_Score=214, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=53.2467532467532, Blast_Score=163, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17169; Mature: 17038

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKPEIAIVMGSKSDWATMSEATQILDQFNLAYHVEVVSAHRTPDKLFSFAESAEQNGY
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
KVIIAGAGGAAHLPGMIAAKTIVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGP
EEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
AGAANAGLLAAQILAAFNSELAQKLHAFRNEQTQSVLDNPDPRN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEKPEIAIVMGSKSDWATMSEATQILDQFNLAYHVEVVSAHRTPDKLFSFAESAEQNGY
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
KVIIAGAGGAAHLPGMIAAKTIVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGP
EEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
AGAANAGLLAAQILAAFNSELAQKLHAFRNEQTQSVLDNPDPRN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 7997179 [H]