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The map label for this gene is tyrP-B [H]

Identifier: 126208079

GI number: 126208079

Start: 682972

End: 684189

Strand: Direct

Name: tyrP-B [H]

Synonym: APL_0597

Alternate gene names: 126208079

Gene position: 682972-684189 (Clockwise)

Preceding gene: 126208078

Following gene: 126208080

Centisome position: 30.03

GC content: 43.43

Gene sequence:

>1218_bases
ATGAAAAATAAAATTTTAGGTAGTGCGTTAATGATTGCCGGCACTACGATTGGTGCGGGGATGTTAGCGATGCCGCTGAC
TTCTGCGGGAATGGGATTTGGAGCGACGGTTGTTTTACTGGTTTGTTTATGGGCGTTATTGGCTTATACCGGTTTATTGT
TTATGGAAGTGTATCAAACTGCTCCCAAGCAAGACGTCGGCGTAGCGAGTCTTGCAGAGCAATATTTCGGCATAACCGGA
CGAGTATTGGCAACCGCAAGTTTATTGATTTTGCTTTATGCTTTATTAGCCGCCTATATTACCGGCGGCGGCTCGTTGCT
TTCGGGATTACTACCTGAAATCGGTGATGCGCATACCACGACTCAAGTAGGGATTTTACTCTTTACCGTATTACTCGGTT
CGTTTGTCGTGATTGGGATTAAAGGCGTTGATGGTTTAACTCGTTTATTATTTATTGGGAAAATCGTTGCGTTTGTCTTT
GTATTACTAATGATGTTACCAAAAGCAAAATTGGAAAATTTAACCGCCGTACCGTTAGATAATCTGTTTGTTGTTTCAGC
CGTGCCGATTTTCTTTACTTCGTTCGGCTTCCACGTGATTATGGCGAGTATCAATACCTATTTAGATGCGGATATTCGTA
AAATTCGTATTGCGATTTATATCGGTACCGCGATTCCGTTGGTGGCGTATTTATTGTGGCAACTTGCAACCCACGGCGTT
TTAACGCAAGCGGAATTTGTGGAGATTTTAAAACAGGATCCGACCTTAAACGGTTTGGTTAAAGCAACCAGTCAAATTAC
CGGCAGCACGATTTTAGGCGAAATGGTACGTTTATTCTCGGCACTTGCATTGATTACCTCATTCTTAGGTGTGGCAATGG
GTATCTTCGAGTGTGTCGGCGATTTATTAAAACGTGTGAATTTACCGGCAAATCGTTTATGGCTGACCCTAGCGACCTTT
ATTCCGCCAGTATTGTTTGCATTATTCTATCCGAACGGATTTATTGCGGCGTTAGGTTATGCGGGTTTATTATTTGCATT
CTACGGCATGTTATTGCCAATCGGTTTGGCGTGGAAAGCGCGCCAGCAACATCCTAATTTGGCGTATCGCGTGATTGGCG
GCAAAGCTGCGCTGATAGTCGCATTAATTGCCGGCATTATTATTATGATTATTCCGTTCCTTATTCAGCTGGGGTACTTG
CCGCAAGTTGCAGGTTAA

Upstream 100 bases:

>100_bases
GATAATAGGGAGTGTAAGCGGTCCGATTTTGCTAATTTTTTACAAATTTCGACCGCTTGTTAAAATTAAATTGTAAACAC
AATGATTGGTTATATTAGAA

Downstream 100 bases:

>100_bases
ATATAAATGCCAAGCGGTCAGAAATTGCAGAAATTTTGCAAATTCTGACCGCTTTTTTATATGATAAAGATGATTGCTTT
ACAGGATTTTTAGTTAGGAA

Product: tyrosine-specific transport protein 2

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 2 [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKNKILGSALMIAGTTIGAGMLAMPLTSAGMGFGATVVLLVCLWALLAYTGLLFMEVYQTAPKQDVGVASLAEQYFGITG
RVLATASLLILLYALLAAYITGGGSLLSGLLPEIGDAHTTTQVGILLFTVLLGSFVVIGIKGVDGLTRLLFIGKIVAFVF
VLLMMLPKAKLENLTAVPLDNLFVVSAVPIFFTSFGFHVIMASINTYLDADIRKIRIAIYIGTAIPLVAYLLWQLATHGV
LTQAEFVEILKQDPTLNGLVKATSQITGSTILGEMVRLFSALALITSFLGVAMGIFECVGDLLKRVNLPANRLWLTLATF
IPPVLFALFYPNGFIAALGYAGLLFAFYGMLLPIGLAWKARQQHPNLAYRVIGGKAALIVALIAGIIIMIIPFLIQLGYL
PQVAG

Sequences:

>Translated_405_residues
MKNKILGSALMIAGTTIGAGMLAMPLTSAGMGFGATVVLLVCLWALLAYTGLLFMEVYQTAPKQDVGVASLAEQYFGITG
RVLATASLLILLYALLAAYITGGGSLLSGLLPEIGDAHTTTQVGILLFTVLLGSFVVIGIKGVDGLTRLLFIGKIVAFVF
VLLMMLPKAKLENLTAVPLDNLFVVSAVPIFFTSFGFHVIMASINTYLDADIRKIRIAIYIGTAIPLVAYLLWQLATHGV
LTQAEFVEILKQDPTLNGLVKATSQITGSTILGEMVRLFSALALITSFLGVAMGIFECVGDLLKRVNLPANRLWLTLATF
IPPVLFALFYPNGFIAALGYAGLLFAFYGMLLPIGLAWKARQQHPNLAYRVIGGKAALIVALIAGIIIMIIPFLIQLGYL
PQVAG
>Mature_405_residues
MKNKILGSALMIAGTTIGAGMLAMPLTSAGMGFGATVVLLVCLWALLAYTGLLFMEVYQTAPKQDVGVASLAEQYFGITG
RVLATASLLILLYALLAAYITGGGSLLSGLLPEIGDAHTTTQVGILLFTVLLGSFVVIGIKGVDGLTRLLFIGKIVAFVF
VLLMMLPKAKLENLTAVPLDNLFVVSAVPIFFTSFGFHVIMASINTYLDADIRKIRIAIYIGTAIPLVAYLLWQLATHGV
LTQAEFVEILKQDPTLNGLVKATSQITGSTILGEMVRLFSALALITSFLGVAMGIFECVGDLLKRVNLPANRLWLTLATF
IPPVLFALFYPNGFIAALGYAGLLFAFYGMLLPIGLAWKARQQHPNLAYRVIGGKAALIVALIAGIIIMIIPFLIQLGYL
PQVAG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=46.1538461538462, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1790145, Length=407, Percent_Identity=27.5184275184275, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1789552, Length=388, Percent_Identity=27.8350515463918, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43157; Mature: 43157

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKILGSALMIAGTTIGAGMLAMPLTSAGMGFGATVVLLVCLWALLAYTGLLFMEVYQT
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APKQDVGVASLAEQYFGITGRVLATASLLILLYALLAAYITGGGSLLSGLLPEIGDAHTT
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
TQVGILLFTVLLGSFVVIGIKGVDGLTRLLFIGKIVAFVFVLLMMLPKAKLENLTAVPLD
HHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCC
NLFVVSAVPIFFTSFGFHVIMASINTYLDADIRKIRIAIYIGTAIPLVAYLLWQLATHGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHHHHHHHHHCCH
LTQAEFVEILKQDPTLNGLVKATSQITGSTILGEMVRLFSALALITSFLGVAMGIFECVG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLKRVNLPANRLWLTLATFIPPVLFALFYPNGFIAALGYAGLLFAFYGMLLPIGLAWKA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQHPNLAYRVIGGKAALIVALIAGIIIMIIPFLIQLGYLPQVAG
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNKILGSALMIAGTTIGAGMLAMPLTSAGMGFGATVVLLVCLWALLAYTGLLFMEVYQT
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APKQDVGVASLAEQYFGITGRVLATASLLILLYALLAAYITGGGSLLSGLLPEIGDAHTT
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
TQVGILLFTVLLGSFVVIGIKGVDGLTRLLFIGKIVAFVFVLLMMLPKAKLENLTAVPLD
HHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCC
NLFVVSAVPIFFTSFGFHVIMASINTYLDADIRKIRIAIYIGTAIPLVAYLLWQLATHGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHHHHHHHHHCCH
LTQAEFVEILKQDPTLNGLVKATSQITGSTILGEMVRLFSALALITSFLGVAMGIFECVG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLKRVNLPANRLWLTLATFIPPVLFALFYPNGFIAALGYAGLLFAFYGMLLPIGLAWKA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQQHPNLAYRVIGGKAALIVALIAGIIIMIIPFLIQLGYLPQVAG
HHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]