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The map label for this gene is tyrP-A [H]

Identifier: 126208078

GI number: 126208078

Start: 681662

End: 682876

Strand: Direct

Name: tyrP-A [H]

Synonym: APL_0596

Alternate gene names: 126208078

Gene position: 681662-682876 (Clockwise)

Preceding gene: 126208077

Following gene: 126208079

Centisome position: 29.97

GC content: 40.66

Gene sequence:

>1215_bases
ATGCAAAATAAAACTTTTGGCAGCACATTGATTGTGGCGGGGACGACAATCGGTGCGGGAATGCTGGCGATGCCTCTCAC
TTCTGCGGGAATCGGTTTCGGCTGGACGGTGGCATTACTCATCGCACTTTGGTTATTATTGTCATTTGGTGCGTTATTAT
TCGTAGAACTTTATCAAAATGCCGAAAGTGATGCGGGTATCGGTACTTTAGCCGAAAAATATTATGGCAACTTCGGACGA
ATCGTTTCTACCGCAGTGTTAGTGATTTTCCTGTATGCCATTCTTTCCGCTTATGTGTCCGGAGGAAGCTCGTTATTGGC
AGGCATCATGCCGACGATCGGCGATAGCGAAACCACCAAAAGAATTGCAGGTGTGATTTTTACCCTTGTGTTCGGTACTT
TTGTTGTTATCGGGACAACCAGTGTGGATGTAGTAAATCGTATTCTTTTCTTAACGAAAATCGGTGCGTTTTTCTTAGTC
TTGGCATTATTATTACCGAATATTTCCGTGGATAATTTACTTGAAATGCCGATTGATAATGCGCTATTGATTTCCGCTAC
ACCGGTTTTCTTTACAGCATTCGGCTTCCATGGTTCAATTCCGAGCTTAAATAAATATTTAGACGGTAATGTCAAAGCGT
TACGTATTTCGATTTTAGTCGGTACGGCGATTCCGTTAGTCGCTTATGTATTATGGCAGCTTGCAACACACGGTTTATTG
AATCAAACCGAATTTTTACAATTGATTGAGAAAGATCCGACATTAAACGGTTTAGCGGAAGCGATTCAGCAAATGACAGG
CAGTTCGTTAATTGGCGGTACGGTTAAATTATTCTCGGCATTGGCGTTGATCACCTCATTTTTAGGGGTTGCATTGGGTT
TATTTGAGTGTTTAGAGGATCTATTTAAGCGAGTACATATTAACGCGCCTCGAATTTCACTCGGTCTTTTAACCTTTATT
CCGCCGATGTTATTTGCCTTTTTCTATCCTGAAGGTTTTATTGCTGCATTAGGTTATGCAGGGCAAATGTTTGCTTTCTA
TGCGCTAGTTTTACCGATTGCGATGGTTTGGAAGTTCCGTAAACAATATCCGGAGGCTAAATACAAAGTATTCGGCGGAA
ATATTGCATTGTTAGTTGCATTATTATTAGCAATATTTATTATTAACGTTCCATTTATTATTGAAGCGGGTTATTTACCG
AAAGTAGTGGGATAA

Upstream 100 bases:

>100_bases
ATGCTGTAATAATATGTTTACAGTGAAAGTTTTTCGTTACATTTTGTTTTTGTTCTTGTAGAATACCTCGACTGATAACA
ATCTTAGAGGTTATAAGAAT

Downstream 100 bases:

>100_bases
TAGGGAGTGTAAGCGGTCCGATTTTGCTAATTTTTTACAAATTTCGACCGCTTGTTAAAATTAAATTGTAAACACAATGA
TTGGTTATATTAGAAATGAA

Product: tyrosine-specific transport protein 1

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1 [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQNKTFGSTLIVAGTTIGAGMLAMPLTSAGIGFGWTVALLIALWLLLSFGALLFVELYQNAESDAGIGTLAEKYYGNFGR
IVSTAVLVIFLYAILSAYVSGGSSLLAGIMPTIGDSETTKRIAGVIFTLVFGTFVVIGTTSVDVVNRILFLTKIGAFFLV
LALLLPNISVDNLLEMPIDNALLISATPVFFTAFGFHGSIPSLNKYLDGNVKALRISILVGTAIPLVAYVLWQLATHGLL
NQTEFLQLIEKDPTLNGLAEAIQQMTGSSLIGGTVKLFSALALITSFLGVALGLFECLEDLFKRVHINAPRISLGLLTFI
PPMLFAFFYPEGFIAALGYAGQMFAFYALVLPIAMVWKFRKQYPEAKYKVFGGNIALLVALLLAIFIINVPFIIEAGYLP
KVVG

Sequences:

>Translated_404_residues
MQNKTFGSTLIVAGTTIGAGMLAMPLTSAGIGFGWTVALLIALWLLLSFGALLFVELYQNAESDAGIGTLAEKYYGNFGR
IVSTAVLVIFLYAILSAYVSGGSSLLAGIMPTIGDSETTKRIAGVIFTLVFGTFVVIGTTSVDVVNRILFLTKIGAFFLV
LALLLPNISVDNLLEMPIDNALLISATPVFFTAFGFHGSIPSLNKYLDGNVKALRISILVGTAIPLVAYVLWQLATHGLL
NQTEFLQLIEKDPTLNGLAEAIQQMTGSSLIGGTVKLFSALALITSFLGVALGLFECLEDLFKRVHINAPRISLGLLTFI
PPMLFAFFYPEGFIAALGYAGQMFAFYALVLPIAMVWKFRKQYPEAKYKVFGGNIALLVALLLAIFIINVPFIIEAGYLP
KVVG
>Mature_404_residues
MQNKTFGSTLIVAGTTIGAGMLAMPLTSAGIGFGWTVALLIALWLLLSFGALLFVELYQNAESDAGIGTLAEKYYGNFGR
IVSTAVLVIFLYAILSAYVSGGSSLLAGIMPTIGDSETTKRIAGVIFTLVFGTFVVIGTTSVDVVNRILFLTKIGAFFLV
LALLLPNISVDNLLEMPIDNALLISATPVFFTAFGFHGSIPSLNKYLDGNVKALRISILVGTAIPLVAYVLWQLATHGLL
NQTEFLQLIEKDPTLNGLAEAIQQMTGSSLIGGTVKLFSALALITSFLGVALGLFECLEDLFKRVHINAPRISLGLLTFI
PPMLFAFFYPEGFIAALGYAGQMFAFYALVLPIAMVWKFRKQYPEAKYKVFGGNIALLVALLLAIFIINVPFIIEAGYLP
KVVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=402, Percent_Identity=48.0099502487562, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790145, Length=406, Percent_Identity=28.0788177339901, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789552, Length=358, Percent_Identity=29.8882681564246, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43364; Mature: 43364

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKTFGSTLIVAGTTIGAGMLAMPLTSAGIGFGWTVALLIALWLLLSFGALLFVELYQN
CCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AESDAGIGTLAEKYYGNFGRIVSTAVLVIFLYAILSAYVSGGSSLLAGIMPTIGDSETTK
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHH
RIAGVIFTLVFGTFVVIGTTSVDVVNRILFLTKIGAFFLVLALLLPNISVDNLLEMPIDN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
ALLISATPVFFTAFGFHGSIPSLNKYLDGNVKALRISILVGTAIPLVAYVLWQLATHGLL
EEEEECCHHHHHHHCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
NQTEFLQLIEKDPTLNGLAEAIQQMTGSSLIGGTVKLFSALALITSFLGVALGLFECLED
CHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRVHINAPRISLGLLTFIPPMLFAFFYPEGFIAALGYAGQMFAFYALVLPIAMVWKFR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQYPEAKYKVFGGNIALLVALLLAIFIINVPFIIEAGYLPKVVG
HHCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHEECCCCCCCCC
>Mature Secondary Structure
MQNKTFGSTLIVAGTTIGAGMLAMPLTSAGIGFGWTVALLIALWLLLSFGALLFVELYQN
CCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AESDAGIGTLAEKYYGNFGRIVSTAVLVIFLYAILSAYVSGGSSLLAGIMPTIGDSETTK
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHH
RIAGVIFTLVFGTFVVIGTTSVDVVNRILFLTKIGAFFLVLALLLPNISVDNLLEMPIDN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
ALLISATPVFFTAFGFHGSIPSLNKYLDGNVKALRISILVGTAIPLVAYVLWQLATHGLL
EEEEECCHHHHHHHCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
NQTEFLQLIEKDPTLNGLAEAIQQMTGSSLIGGTVKLFSALALITSFLGVALGLFECLED
CHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFKRVHINAPRISLGLLTFIPPMLFAFFYPEGFIAALGYAGQMFAFYALVLPIAMVWKFR
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQYPEAKYKVFGGNIALLVALLLAIFIINVPFIIEAGYLPKVVG
HHCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]