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The map label for this gene is hutC [H]

Identifier: 126176438

GI number: 126176438

Start: 4980317

End: 4981024

Strand: Reverse

Name: hutC [H]

Synonym: Sbal_4253

Alternate gene names: 126176438

Gene position: 4981024-4980317 (Counterclockwise)

Preceding gene: 126176440

Following gene: 126176437

Centisome position: 97.15

GC content: 51.98

Gene sequence:

>708_bases
TTGGCTATTCCTAAGTTTGCAGAAATTAAGCAATACATTATCTCCTCTATCGAATCTGGCGAGTGGGAAGAAAACGCCCG
CGTGCCTTCCGAGAATCAGCTTGCCGACTTGTTTACCTGCAGCCGAATGACGGCGCGACGTGCGTTAACCGAGCTTACGG
ATAGCGGCGTACTCGAACGAGCCCAAGGGCTTGGTACCTTTGTGGCTGGGCGTAAATCCCAGTCGTCTATGTTGGCGATT
CGCAATATTGCCGATGAAATTAAAGACCGCGGCCACGGCTATAGCGTACAGCAATGGGTGTTAGAACAAACCGTTGCCAG
TACAACTATCGCAATTTCCCTTGGGCTTGAGCGCGGTGCAAAGGTATTCCATTCGATCTTAGTGCATTGCGAGCAGGGGT
TACCGCTGCAAGTCGAGGAGCGTTACGTGAACCCCGAGTTGGTGCCCGACTATTTATTGCAGGATTTTACCTTGCAGACG
CCCCACGAATATTTATCCCAAGTGGCACCGTTGACCGAGGCGCATCACACGATTGAGGCGATTATCGCCAGCGCCGAATT
ACAGCAAAGGCTTGAAATCCCCGCCACAGAGCCCTGTTTACAGATTTTACGCCGTACTTGGTCGCGTCAAGGCGTCGTGA
GTTTTGCCAAGTTAGTTCACCCCGGCAGCCGCTTTAAACTCGGCGGCCACTTAACTTTTAGCAAGTAG

Upstream 100 bases:

>100_bases
TGACAGACCCGTGTCTTTGTCGCCTGCGTCAGTGCCTCTTTAGCAAGCATGACTTTCGCAAGGGCACAGGAACAAGAAGC
TGAATTTAAGAGGAAGTGTT

Downstream 100 bases:

>100_bases
CGCCAGTGGCGTTATTTACCGATGTAAATCAGTCACTCCAATAGCTGTACCCTTATAAGTTAAAAGATAAAAACACCATA
AAAACATAAGTTAAAAGATA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MAIPKFAEIKQYIISSIESGEWEENARVPSENQLADLFTCSRMTARRALTELTDSGVLERAQGLGTFVAGRKSQSSMLAI
RNIADEIKDRGHGYSVQQWVLEQTVASTTIAISLGLERGAKVFHSILVHCEQGLPLQVEERYVNPELVPDYLLQDFTLQT
PHEYLSQVAPLTEAHHTIEAIIASAELQQRLEIPATEPCLQILRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFSK

Sequences:

>Translated_235_residues
MAIPKFAEIKQYIISSIESGEWEENARVPSENQLADLFTCSRMTARRALTELTDSGVLERAQGLGTFVAGRKSQSSMLAI
RNIADEIKDRGHGYSVQQWVLEQTVASTTIAISLGLERGAKVFHSILVHCEQGLPLQVEERYVNPELVPDYLLQDFTLQT
PHEYLSQVAPLTEAHHTIEAIIASAELQQRLEIPATEPCLQILRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFSK
>Mature_234_residues
AIPKFAEIKQYIISSIESGEWEENARVPSENQLADLFTCSRMTARRALTELTDSGVLERAQGLGTFVAGRKSQSSMLAIR
NIADEIKDRGHGYSVQQWVLEQTVASTTIAISLGLERGAKVFHSILVHCEQGLPLQVEERYVNPELVPDYLLQDFTLQTP
HEYLSQVAPLTEAHHTIEAIIASAELQQRLEIPATEPCLQILRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFSK

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=147, Percent_Identity=27.891156462585, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790118, Length=222, Percent_Identity=22.972972972973, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786950, Length=212, Percent_Identity=23.5849056603774, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790540, Length=199, Percent_Identity=27.6381909547739, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26249; Mature: 26118

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPKFAEIKQYIISSIESGEWEENARVPSENQLADLFTCSRMTARRALTELTDSGVLER
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGLGTFVAGRKSQSSMLAIRNIADEIKDRGHGYSVQQWVLEQTVASTTIAISLGLERGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCHHHHH
KVFHSILVHCEQGLPLQVEERYVNPELVPDYLLQDFTLQTPHEYLSQVAPLTEAHHTIEA
HHHHHHHHHHCCCCCEEHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHH
IIASAELQQRLEIPATEPCLQILRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCEEECCC
>Mature Secondary Structure 
AIPKFAEIKQYIISSIESGEWEENARVPSENQLADLFTCSRMTARRALTELTDSGVLER
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGLGTFVAGRKSQSSMLAIRNIADEIKDRGHGYSVQQWVLEQTVASTTIAISLGLERGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCHHHHH
KVFHSILVHCEQGLPLQVEERYVNPELVPDYLLQDFTLQTPHEYLSQVAPLTEAHHTIEA
HHHHHHHHHHCCCCCEEHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHH
IIASAELQQRLEIPATEPCLQILRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFSK
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]