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The map label for this gene is hutU [H]

Identifier: 126176437

GI number: 126176437

Start: 4978463

End: 4980130

Strand: Reverse

Name: hutU [H]

Synonym: Sbal_4252

Alternate gene names: 126176437

Gene position: 4980130-4978463 (Counterclockwise)

Preceding gene: 126176438

Following gene: 126176436

Centisome position: 97.13

GC content: 53.48

Gene sequence:

>1668_bases
ATGGACAAGCGCCACGACCCAAGCCGCCGCATTATTGCACCGCATGGCACACAATTAAGCTGCAAAAGCTGGTTGACCGA
AGCGCCAATGCGCATGTTAATGAACAACTTGCACCCAGATGTGGCCGAGCGCCCAGAAGACTTAGTCGTCTATGGTGGTA
TCGGCCGCGCCGCTCGCGACTGGGATTGCTATGACAAAATCATCGAAGTCTTACAACGCCTCGAAGATGACGAAACCTTA
TTAGTGCAATCGGGCAAACCTGTGGGCGTATTCCGCACCCATGCCGATGCACCTCGCGTGTTAATCGCTAACTCAAACCT
AGTACCACATTGGGCGAACTGGGAGCATTTCAACGAGTTAGATAAGCTAGGTTTGGCCATGTATGGCCAGATGACGGCGG
GTTCTTGGATCTACATTGGTACTCAAGGCATAGTTCAAGGTACCTACGAGACCTTTGTGTCTGTAGCGAAACAGCACTTT
GAGGGTATCTCCAAAGGCAAATGGATCCTCACTGGCGGGTTAGGCGGCATGGGCGGCGCGCAAACGCTGGCGGGCACTAT
GGCTGGCTTCTCGGTGTTAGCCTGTGAAGTCGACGAGACTCGCATCGATTTCCGTTTGCGCACTCGTTATGTCGACAAAA
AAGCCACTTCGCTCGATGAAGCATTGGCGATGATTGAAGAGGCAAACCAAGCTGGCAAGCCAGTATCAGTGGGCTTATTA
GCGAATGCCGCCGATGTGTTTGCCGAACTGGTTAAGCGCGGCGTTACCCCTGATGTCGTGACCGACCAAACCTCGGCCCA
CGATCCATTAAACGGTTATCTGCCGCAGGGTTGGACTATGGCAGAGGCTGCGGCCATGCGTAAAACCGACGAAGCGGGCG
TAGTGAAAGCGGCAAAAGCCTCGATGGCGGTGCAAGTACAAGCCATGCTCGATTTGCAAACTGCCGGCGCAGCTACCTTA
GATTACGGTAACAACATTCGCCAAATGGCGTTTGAGATGGGCGTTGAAAACGCCTTTGATTTCCCAGGTTTTGTACCTGC
TTATATTCGTCCGCTGTTCTGTGAAGGTATTGGTCCATTCCGCTGGGTAGCACTGTCTGGCGATCCAGAAGATATCTACA
AAACCGACGCTAAAGTGAAAGAGCTTATTCCTGATAATCCACACTTGCACAATTGGTTAGACATGGCGCGTGAGCGTATC
GCCTTCCAAGGTCTGCCTGCGCGTATCTGCTGGGTCGGCTTGAAAGATCGCGCTCGTTTAGCGTTAGCTTTTAACGAAAT
GGTCAAAAAAGGTGAGTTGTCGGCGCCCGTGGTAATTGGTCGCGACCACTTAGATTCTGGCTCTGTTGCCAGCCCGAACC
GCGAAACCGAATCTATGCTGGACGGCTCAGATGCAGTATCCGATTGGCCATTATTGAATGCACTACTCAACACCGCCAGC
GGCGCAACTTGGGTGTCATTACACCACGGCGGCGGCGTCGGCATGGGCTTTAGCCAACATTCGGGTGTGGTGATTGTGTG
CGACGGAACCGACGCGGCAGCAAAACGGGTTGGCCGTGTGCTGTGGAATGACCCAGCGACAGGCGTGATGCGCCATGCCG
ATGCGGGTTACGAGATTGCGAAAAACTGCGCCAAAGAGCAGGGGCTCGACTTACCTATGCAAGAGTAG

Upstream 100 bases:

>100_bases
TAAGTTAAAAGATAAAAACACCATAAAAACAATAGTGTTAACCCGTATTAGCGACTCAGCAAATACGAGTTAGCACCACA
GGTTGAAAGAGGAAAATTCA

Downstream 100 bases:

>100_bases
CCGATGCTAACTTCTTAAAATAACAATAATAACTAAAAGCTTGGAGCTAAAAATATGAAATCTGTGAATCACTTAGTGTT
AACGCCGGGCAGCTTGAGCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLQRLEDDETL
LVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHF
EGISKGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEEANQAGKPVSVGLL
ANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKASMAVQVQAMLDLQTAGAATL
DYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLALAFNEMVKKGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMQE

Sequences:

>Translated_555_residues
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLQRLEDDETL
LVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHF
EGISKGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEEANQAGKPVSVGLL
ANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKASMAVQVQAMLDLQTAGAATL
DYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLALAFNEMVKKGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMQE
>Mature_555_residues
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLQRLEDDETL
LVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHF
EGISKGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEEANQAGKPVSVGLL
ANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKASMAVQVQAMLDLQTAGAATL
DYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLALAFNEMVKKGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMQE

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=563, Percent_Identity=34.6358792184725, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI260306182, Length=232, Percent_Identity=37.0689655172414, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=557, Percent_Identity=33.3931777378815, Blast_Score=305, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60353; Mature: 60353

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WDCYDKIIEVLQRLEDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHFEGISKGKWILTGGLGGMGGA
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
QTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEEANQAGKPVSVGLL
HHHHHHHHCCEEEEEECCCCEECEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHH
ANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
SMAVQVQAMLDLQTAGAATLDYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPF
HHEEEEHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
ALAFNEMVKKGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTAS
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KNCAKEQGLDLPMQE
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MDKRHDPSRRIIAPHGTQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WDCYDKIIEVLQRLEDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKLGLAMYGQMTAGSWIYIGTQGIVQGTYETFVSVAKQHFEGISKGKWILTGGLGGMGGA
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
QTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMIEEANQAGKPVSVGLL
HHHHHHHHCCEEEEEECCCCEECEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHH
ANAADVFAELVKRGVTPDVVTDQTSAHDPLNGYLPQGWTMAEAAAMRKTDEAGVVKAAKA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
SMAVQVQAMLDLQTAGAATLDYGNNIRQMAFEMGVENAFDFPGFVPAYIRPLFCEGIGPF
HHEEEEHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHH
ALAFNEMVKKGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLLNALLNTAS
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTDAAAKRVGRVLWNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KNCAKEQGLDLPMQE
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA