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The map label for this gene is moeA [H]

Identifier: 126176408

GI number: 126176408

Start: 4950286

End: 4951539

Strand: Direct

Name: moeA [H]

Synonym: Sbal_4223

Alternate gene names: 126176408

Gene position: 4950286-4951539 (Clockwise)

Preceding gene: 126176406

Following gene: 126176409

Centisome position: 96.55

GC content: 50.72

Gene sequence:

>1254_bases
ATGTCCGTAAAAGCCGATCCTTGTTCGCAACCTAGCTTAATGCATCCAGATCAAGCTATTTCCCTTTTGCTCGAACAAGT
TAGCCCAGTGTCAGAGACAGAAGTCGTATTGCTTCCCCATGCTCTTGGCCGCGTCCTTGCAGAAGATCTCGCTTCCTGCA
TCGACCTGCCACCCTTCGACAACTCCTCCATGGACGGTTACGCCTTCCGTTTTGTCGACTTGAATACGCAAACCAATCAC
ACCTCATTGCGCCTTATCGGCAGTTCGTTCGCCGGCCATGGTTTTGAAGGTGAAGCCAAACCTAATACTTGCATACGGAT
CATGACGGGCGCGCCCGTGCCTGCGGGTTATGACACAGTACAAATGCAGGAAGAAGCCGAAGTTGAAGGTGAGATTATTC
ATATTCGCCATCCTAAGGCGCAAGGTGCCAATGTGCGTTGTCGTGGCGAAGAGCTGACCCAAGGCACTAAAGTACTTACT
GCTGGTATTCAAATTGGCGCTGCCGAACTCGGCGTATTGGCCACTATTGGTATCAGCCAAGTGCGAGTCTATCGTCAACT
TAAGGTGGCATTTTTCTCCACTGGCGATGAACTGCGTCCGGTTGGCAGCGAACTCGCGCTAGGGCAAATTTACGATTCAA
ACCGTTACTCGATTCAAGGTTTACTCAGCCGCGCTAATGTGGAATGGCTCGATTTAGGCGTGATTGCCGATGATCCTGAA
GCCATACGTCAGGCATTTCGCCAAGCCGCCAGCCAAGCAGACATGGTGCTGACCTCGGGCGGCGTGTCGGTCGGCGAAGC
GGATTTCACGAAACAAATTCTCGATGAAGAAGGCAAAATCACCTTCTGGAAACTCGCCATCAAACCAGGCAAGCCTTTCG
CCATGGGCAAAATTGGCAAGGCGGTATTCTGTGGTTTACCAGGCAATCCCGTGTCTTCTATGGTGACGTTTTACAAACTC
GTTTGGCCAATACTGAACAAGATGCAGGGTTTAACCCCAGTTGCACCTTTGATGTTAGACGCCACTCTGACAACACCTGT
GCGTAAACAACCGGGCCGCGTCGAATATCAACGGGGCATTTTAAGCCGTAATACACAAGGTAAACTCGAGGTTGCTATTA
CTGGTAGCCAAGGTTCAGGTATGTTGACCTCAATGAGCCTAGCGAACTGTTTCGTTTTATTGGAACAATTCCAAGGGGAT
ACTGCCGCTGGCACCCAAGTGACAGTCGAGCCCTTTAACAGCGTGCTTTGCTAG

Upstream 100 bases:

>100_bases
ATCATAGCCATCGCCGATCACCGTGGCATAATAGCCAATCATAGTCAGGTGGAAATTCATTCAGCGTCATCACGACCCAT
TGCATATAAGGCAGACCCTC

Downstream 100 bases:

>100_bases
GAAAATCTCCATGAATGTGCCTGACGATATTCTCAGCGACAGCGAACTCTTAAGATACAGCCGTCAGATCTCCATCAAAG
CCATGGATATCGACGGCCAA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSVKADPCSQPSLMHPDQAISLLLEQVSPVSETEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNH
TSLRLIGSSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLT
AGIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELALGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKL
VWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNTQGKLEVAITGSQGSGMLTSMSLANCFVLLEQFQGD
TAAGTQVTVEPFNSVLC

Sequences:

>Translated_417_residues
MSVKADPCSQPSLMHPDQAISLLLEQVSPVSETEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNH
TSLRLIGSSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLT
AGIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELALGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKL
VWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNTQGKLEVAITGSQGSGMLTSMSLANCFVLLEQFQGD
TAAGTQVTVEPFNSVLC
>Mature_416_residues
SVKADPCSQPSLMHPDQAISLLLEQVSPVSETEVVLLPHALGRVLAEDLASCIDLPPFDNSSMDGYAFRFVDLNTQTNHT
SLRLIGSSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTVQMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTA
GIQIGAAELGVLATIGISQVRVYRQLKVAFFSTGDELRPVGSELALGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPEA
IRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGKAVFCGLPGNPVSSMVTFYKLV
WPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGILSRNTQGKLEVAITGSQGSGMLTSMSLANCFVLLEQFQGDT
AAGTQVTVEPFNSVLC

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=393, Percent_Identity=36.6412213740458, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI66932975, Length=393, Percent_Identity=36.6412213740458, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1787049, Length=405, Percent_Identity=48.8888888888889, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25147659, Length=398, Percent_Identity=30.4020100502513, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=333, Percent_Identity=29.7297297297297, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136978, Length=384, Percent_Identity=28.125, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24638841, Length=384, Percent_Identity=28.125, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44825; Mature: 44694

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKADPCSQPSLMHPDQAISLLLEQVSPVSETEVVLLPHALGRVLAEDLASCIDLPPFD
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
NSSMDGYAFRFVDLNTQTNHTSLRLIGSSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTV
CCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
QMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTAGIQIGAAELGVLATIGISQ
EECCCCCCCCCEEEEECCCCCCCCEEECCHHHCCCCEEEEECCEECHHHHHHHHHCCHHH
VRVYRQLKVAFFSTGDELRPVGSELALGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
HHHHHHHEEEEECCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHCCCEEEEEEEEECCHH
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGK
HHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCC
AVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGI
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
LSRNTQGKLEVAITGSQGSGMLTSMSLANCFVLLEQFQGDTAAGTQVTVEPFNSVLC
HCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHCCCC
>Mature Secondary Structure 
SVKADPCSQPSLMHPDQAISLLLEQVSPVSETEVVLLPHALGRVLAEDLASCIDLPPFD
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
NSSMDGYAFRFVDLNTQTNHTSLRLIGSSFAGHGFEGEAKPNTCIRIMTGAPVPAGYDTV
CCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCE
QMQEEAEVEGEIIHIRHPKAQGANVRCRGEELTQGTKVLTAGIQIGAAELGVLATIGISQ
EECCCCCCCCCEEEEECCCCCCCCEEECCHHHCCCCEEEEECCEECHHHHHHHHHCCHHH
VRVYRQLKVAFFSTGDELRPVGSELALGQIYDSNRYSIQGLLSRANVEWLDLGVIADDPE
HHHHHHHEEEEECCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHCCCEEEEEEEEECCHH
AIRQAFRQAASQADMVLTSGGVSVGEADFTKQILDEEGKITFWKLAIKPGKPFAMGKIGK
HHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCC
AVFCGLPGNPVSSMVTFYKLVWPILNKMQGLTPVAPLMLDATLTTPVRKQPGRVEYQRGI
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
LSRNTQGKLEVAITGSQGSGMLTSMSLANCFVLLEQFQGDTAAGTQVTVEPFNSVLC
HCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]