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The map label for this gene is frdB [H]

Identifier: 126175945

GI number: 126175945

Start: 4402033

End: 4402758

Strand: Direct

Name: frdB [H]

Synonym: Sbal_3751

Alternate gene names: 126175945

Gene position: 4402033-4402758 (Clockwise)

Preceding gene: 126175944

Following gene: 126175946

Centisome position: 85.85

GC content: 51.38

Gene sequence:

>726_bases
ATGAGCCGTCAAATCAGCTTTAATATCTTCCGCTACGATCCGCAAGATGGCCAAGACAAGCCAAAGATGGAACGTTATCA
GTTGACTGAAACACCGGGCATGACAGTGTTTATCGCCTTAAATCAATTGCGTGAACAACAAGATCCCTCACTGCAGTTCG
ACTTTGTCTGCCGCGCGGGCATCTGTGGCAGTTGCGCCATGGTGATCAATGGTTTCCCCACATTGGCCTGTCGCACGTTA
ACAGCGAATTATCCCAATGGTGAAATCACCCTAATGCCGCTGCCCGGCTTCGAACTGATTGGCGATTTGTCGGTGAACAC
AGGCAAATTTATGCGCGAATTAGCCGAACGCTTGAAACTCTGGCTGCATCCTAAACCCGATGATCAGGACATTCATCGCC
TCGAAAATCCAATGGCACCCGAAGAAGCCGCGCGGATCTATGAGCTAGAACGCTGCGTCGAATGTGGCGTTTGCGTGTCA
GCCTGCGCCACCAAACAAATGCGTGACACCTTTGTCGGCGCGGTTGGCATGATGAAAATTGCCCGCTTCGAAATGGATAG
CAGAGACAGCCGCAGTGCGGATGATTTCTACCATGTGATTGGCAATCAAGACGGCGTCTTCGGTTGTATGACGCTACTCG
GCTGCCAAGATAACTGCCCTAAAGATTTGCCGCACATGCAGCAGATTGCTTACCTGCGCCGCAAAATGGCCGCAAGCATA
CTCTAG

Upstream 100 bases:

>100_bases
TAATGCCATACGAGCTGCCAAGTCATCTGCAGGCTCCCAATGGACGCCTCAGCGATACCTTAGCGATCACTCCAGCCCAA
CCGGTAGGGAATAAACCACT

Downstream 100 bases:

>100_bases
TTTTCCTTAACCTAAAGTCCCGCTGCGTTAGCGGGACTTTAGGGCAACACCTTTCCCAAACCAGCGGGTAAATCATATCT
GCCCGCTGCAGATATGCGAC

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSRQISFNIFRYDPQDGQDKPKMERYQLTETPGMTVFIALNQLREQQDPSLQFDFVCRAGICGSCAMVINGFPTLACRTL
TANYPNGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKPDDQDIHRLENPMAPEEAARIYELERCVECGVCVS
ACATKQMRDTFVGAVGMMKIARFEMDSRDSRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAASI
L

Sequences:

>Translated_241_residues
MSRQISFNIFRYDPQDGQDKPKMERYQLTETPGMTVFIALNQLREQQDPSLQFDFVCRAGICGSCAMVINGFPTLACRTL
TANYPNGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKPDDQDIHRLENPMAPEEAARIYELERCVECGVCVS
ACATKQMRDTFVGAVGMMKIARFEMDSRDSRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAASI
L
>Mature_240_residues
SRQISFNIFRYDPQDGQDKPKMERYQLTETPGMTVFIALNQLREQQDPSLQFDFVCRAGICGSCAMVINGFPTLACRTLT
ANYPNGEITLMPLPGFELIGDLSVNTGKFMRELAERLKLWLHPKPDDQDIHRLENPMAPEEAARIYELERCVECGVCVSA
CATKQMRDTFVGAVGMMKIARFEMDSRDSRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAASIL

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=239, Percent_Identity=30.9623430962343, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1786943, Length=235, Percent_Identity=34.0425531914894, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790596, Length=223, Percent_Identity=26.9058295964126, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17533915, Length=235, Percent_Identity=28.0851063829787, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322987, Length=240, Percent_Identity=27.0833333333333, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=28.5106382978723, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=26.9230769230769, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27265; Mature: 27134

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
10.4 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
10.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQISFNIFRYDPQDGQDKPKMERYQLTETPGMTVFIALNQLREQQDPSLQFDFVCRAG
CCCEEEEEEEEECCCCCCCCCCHHHEEECCCCCCEEEEEEHHHHHCCCCCCEEEHEECCC
ICGSCAMVINGFPTLACRTLTANYPNGEITLMPLPGFELIGDLSVNTGKFMRELAERLKL
CCHHHHHHHCCCCHHEEEEEECCCCCCEEEEEECCCHHHEECCCCCHHHHHHHHHHHHHE
WLHPKPDDQDIHRLENPMAPEEAARIYELERCVECGVCVSACATKQMRDTFVGAVGMMKI
ECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFEMDSRDSRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAASI
HHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
SRQISFNIFRYDPQDGQDKPKMERYQLTETPGMTVFIALNQLREQQDPSLQFDFVCRAG
CCEEEEEEEEECCCCCCCCCCHHHEEECCCCCCEEEEEEHHHHHCCCCCCEEEHEECCC
ICGSCAMVINGFPTLACRTLTANYPNGEITLMPLPGFELIGDLSVNTGKFMRELAERLKL
CCHHHHHHHCCCCHHEEEEEECCCCCCEEEEEECCCHHHEECCCCCHHHHHHHHHHHHHE
WLHPKPDDQDIHRLENPMAPEEAARIYELERCVECGVCVSACATKQMRDTFVGAVGMMKI
ECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFEMDSRDSRSADDFYHVIGNQDGVFGCMTLLGCQDNCPKDLPHMQQIAYLRRKMAASI
HHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 10586875; 11248702 [H]