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The map label for this gene is frdA [H]

Identifier: 126175944

GI number: 126175944

Start: 4400027

End: 4402036

Strand: Direct

Name: frdA [H]

Synonym: Sbal_3750

Alternate gene names: 126175944

Gene position: 4400027-4402036 (Clockwise)

Preceding gene: 126175943

Following gene: 126175945

Centisome position: 85.81

GC content: 51.79

Gene sequence:

>2010_bases
TTGAAAATCATTTATACAGACTCATTAGTCATTGGCGCAGGATTGGCAGGCCTCAGAGTCGCGATTGCCACCAAAGAGCG
AGGCCTAGATACCTTAGTGCTATCGTTAATTCCCGCAAAACGTTCACATTCGGCCGCCGCACAGGGCGGAATGCAAGCCA
GCCTAGGCAATACCGTTAAAGGCATGGGCGATAACGAAGACATTCACTTTCAAGACACAGTCAAAGGTTCTGACTGGGGT
TGCGATCAAGACGTCGCCCGCATGTTTGCCCACGTTGCACCGAAAGCGATCCGCGAACTCACCAACTGGGGCGTGCCTTG
GTCAAGGATTTCCGCCGGCCCACGCGAAGTCATCATGAATGCGCAAAGGGTAACGCTCAATGAGGCCGAAGAAGCTCACG
GCCTGATCAATGCCCGCGATTTTGGTGGCACTAAAAAATGGCGTACTTGTTACACCGCCGACGGCACAGGCCACTCTTTA
CTGTATGCCGTCGATAACCAAGCTATTTCTATGGGCATTCCTGTACATGAACGGATTGAAGCCCTGTCGCTTATCCATGA
CGGTAAACGTTGCCATGGGGTGATTGCCCGCTGTTTAGTCACAGGTGAACTGCGCGCTTATATAGCCAAATCCACCACTA
TCGCCACCGGCGGTTATGGCAAGATTTATGAAATATCGACCAATGCCACCATCTGCGAAGGCATAGGCCAAGCGTTAGCA
CTCGACACAGGTATCGCCACCTTAGGCAATATGGAAGCGGTGCAGTTTCACCCCACCGCCATAGTGCCTGCGGGGATCCT
CACAACTGAAGGGTGTCGTGGTGATGGCGGTATCCTGCGCGATAAAGACGGTCATCGCTTTATGCCAGATTACGAGCCAG
AGAAAAAAGAACTCGCCTCCCGCGATGTGGTTTCCCGCCGCATGACAGAGCACATGCGCAAAGGCAATGGCGTCGAAAGC
CCTTATGGCCCGCATCTATGGCTGGATATTACGCAGCTGGGCCGTGAACATATCGAAACTAACCTGCGCGAAGTGAAAGA
GATTTGTGATTACTTCCTCGGTATCGATCCTTGCAAAGATTGGATCCCCGTCCGCCCTACCCAGCATTACTCTATGGGCG
GCGTGCGCACCAATGCCACTGGCGAGAGTCCACAACTCAAGGGGCTGTTCAGCGTCGGAGAAGCGGCCTGTTGGGACATG
CATGGCTTTAACCGTTTAGGCGGTAATTCGGTGGCAGAAACTGTGGTCGGCGGCATGATCATCGGCAAATATGTGGCTGA
TTTTTGTGAGAATAACGATTTAGAAATTGATACTGCGCTGACTCAAAAATTCATCGATAAATTACAGCAAGAAATCGATG
GGCTGGTCGAAGGCAACGGTACAGAAAACCCCTTCCAAATAAAGAAAGAAATGCAACGCATCATGATGAACTACGTCGGG
ATCTTCCGTAATGGACCCGAATTAGATAAAGCCATCAAAGGCTTGAAAGACTTACTGCTGCGGGCAAAAAATCTCGGTCT
TAAATGTAAAAAACGTCACGCTAATCCTGAGTTAGTCGAAGCACTACGCGTCACCCGTATGTTGAAAGTGGCCCTCACCG
TCGCCTGTGGCGCAGAGGCTCGCACTGAAAGTCGCGGCGCCCATTCACGGGAAGACTACCCACAACGCAACGATAAAGAT
TGGCTCAACCGCACGCTGGCAACTTGGCCAGATGCCGAGTCACTGGAACCTGTGCTGCGTTATGAAGCGTTAGATGTGAT
GAAAATGGAGCTACCACCGGGATACCGAGGCTACGGCAACGATAACACTATCGCCCATCCTGATACCGAAAAACGCGTAC
AAGAAATCAATCAAGTGCTCGCGCGCTTAGGTGACGATCCCGATAGAAACACACTGCAGCGAGCCCTAATGCCATACGAG
CTGCCAAGTCATCTGCAGGCTCCCAATGGACGCCTCAGCGATACCTTAGCGATCACTCCAGCCCAACCGGTAGGGAATAA
ACCACTATGA

Upstream 100 bases:

>100_bases
ACGGATCCTCCTCTGATACATAGTTGCCGCGCATCTATGCCCGAGGAGTGCAATGATAAATCCATGAAATGTTATCTAAA
TTATTAGATAAGGATCTGAT

Downstream 100 bases:

>100_bases
GCCGTCAAATCAGCTTTAATATCTTCCGCTACGATCCGCAAGATGGCCAAGACAAGCCAAAGATGGAACGTTATCAGTTG
ACTGAAACACCGGGCATGAC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MKIIYTDSLVIGAGLAGLRVAIATKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDNEDIHFQDTVKGSDWG
CDQDVARMFAHVAPKAIRELTNWGVPWSRISAGPREVIMNAQRVTLNEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNQAISMGIPVHERIEALSLIHDGKRCHGVIARCLVTGELRAYIAKSTTIATGGYGKIYEISTNATICEGIGQALA
LDTGIATLGNMEAVQFHPTAIVPAGILTTEGCRGDGGILRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGNGVES
PYGPHLWLDITQLGREHIETNLREVKEICDYFLGIDPCKDWIPVRPTQHYSMGGVRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSVAETVVGGMIIGKYVADFCENNDLEIDTALTQKFIDKLQQEIDGLVEGNGTENPFQIKKEMQRIMMNYVG
IFRNGPELDKAIKGLKDLLLRAKNLGLKCKKRHANPELVEALRVTRMLKVALTVACGAEARTESRGAHSREDYPQRNDKD
WLNRTLATWPDAESLEPVLRYEALDVMKMELPPGYRGYGNDNTIAHPDTEKRVQEINQVLARLGDDPDRNTLQRALMPYE
LPSHLQAPNGRLSDTLAITPAQPVGNKPL

Sequences:

>Translated_669_residues
MKIIYTDSLVIGAGLAGLRVAIATKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDNEDIHFQDTVKGSDWG
CDQDVARMFAHVAPKAIRELTNWGVPWSRISAGPREVIMNAQRVTLNEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNQAISMGIPVHERIEALSLIHDGKRCHGVIARCLVTGELRAYIAKSTTIATGGYGKIYEISTNATICEGIGQALA
LDTGIATLGNMEAVQFHPTAIVPAGILTTEGCRGDGGILRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGNGVES
PYGPHLWLDITQLGREHIETNLREVKEICDYFLGIDPCKDWIPVRPTQHYSMGGVRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSVAETVVGGMIIGKYVADFCENNDLEIDTALTQKFIDKLQQEIDGLVEGNGTENPFQIKKEMQRIMMNYVG
IFRNGPELDKAIKGLKDLLLRAKNLGLKCKKRHANPELVEALRVTRMLKVALTVACGAEARTESRGAHSREDYPQRNDKD
WLNRTLATWPDAESLEPVLRYEALDVMKMELPPGYRGYGNDNTIAHPDTEKRVQEINQVLARLGDDPDRNTLQRALMPYE
LPSHLQAPNGRLSDTLAITPAQPVGNKPL
>Mature_669_residues
MKIIYTDSLVIGAGLAGLRVAIATKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNTVKGMGDNEDIHFQDTVKGSDWG
CDQDVARMFAHVAPKAIRELTNWGVPWSRISAGPREVIMNAQRVTLNEAEEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAVDNQAISMGIPVHERIEALSLIHDGKRCHGVIARCLVTGELRAYIAKSTTIATGGYGKIYEISTNATICEGIGQALA
LDTGIATLGNMEAVQFHPTAIVPAGILTTEGCRGDGGILRDKDGHRFMPDYEPEKKELASRDVVSRRMTEHMRKGNGVES
PYGPHLWLDITQLGREHIETNLREVKEICDYFLGIDPCKDWIPVRPTQHYSMGGVRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSVAETVVGGMIIGKYVADFCENNDLEIDTALTQKFIDKLQQEIDGLVEGNGTENPFQIKKEMQRIMMNYVG
IFRNGPELDKAIKGLKDLLLRAKNLGLKCKKRHANPELVEALRVTRMLKVALTVACGAEARTESRGAHSREDYPQRNDKD
WLNRTLATWPDAESLEPVLRYEALDVMKMELPPGYRGYGNDNTIAHPDTEKRVQEINQVLARLGDDPDRNTLQRALMPYE
LPSHLQAPNGRLSDTLAITPAQPVGNKPL

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=543, Percent_Identity=37.7532228360958, Blast_Score=328, Evalue=1e-89,
Organism=Escherichia coli, GI1786942, Length=613, Percent_Identity=38.0097879282219, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1790597, Length=583, Percent_Identity=36.1921097770154, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=28.2918149466192, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=38.1818181818182, Blast_Score=324, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=38.4615384615385, Blast_Score=316, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=618, Percent_Identity=37.0550161812298, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=35.7627118644068, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI17137288, Length=603, Percent_Identity=35.6550580431177, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24655642, Length=603, Percent_Identity=35.6550580431177, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24655647, Length=603, Percent_Identity=35.6550580431177, Blast_Score=327, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24663005, Length=574, Percent_Identity=33.9721254355401, Blast_Score=283, Evalue=4e-76,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73576; Mature: 73576

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIYTDSLVIGAGLAGLRVAIATKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEECCCHHHCCHHHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCC
GMGDNEDIHFQDTVKGSDWGCDQDVARMFAHVAPKAIRELTNWGVPWSRISAGPREVIMN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHC
AQRVTLNEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNQAISMGIPVHERIE
CHHHEHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEECCCHHHHHH
ALSLIHDGKRCHGVIARCLVTGELRAYIAKSTTIATGGYGKIYEISTNATICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHH
LDTGIATLGNMEAVQFHPTAIVPAGILTTEGCRGDGGILRDKDGHRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RDVVSRRMTEHMRKGNGVESPYGPHLWLDITQLGREHIETNLREVKEICDYFLGIDPCKD
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGVRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSVAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCCHHHHHHHHHHH
IGKYVADFCENNDLEIDTALTQKFIDKLQQEIDGLVEGNGTENPFQIKKEMQRIMMNYVG
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAIKGLKDLLLRAKNLGLKCKKRHANPELVEALRVTRMLKVALTVACGAEA
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
RTESRGAHSREDYPQRNDKDWLNRTLATWPDAESLEPVLRYEALDVMKMELPPGYRGYGN
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHEEECCCCCCCCCC
DNTIAHPDTEKRVQEINQVLARLGDDPDRNTLQRALMPYELPSHLQAPNGRLSDTLAITP
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECC
AQPVGNKPL
CCCCCCCCC
>Mature Secondary Structure
MKIIYTDSLVIGAGLAGLRVAIATKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNTVK
CEEEEECCCHHHCCHHHHEEEEEECCCCHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCC
GMGDNEDIHFQDTVKGSDWGCDQDVARMFAHVAPKAIRELTNWGVPWSRISAGPREVIMN
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHC
AQRVTLNEAEEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAVDNQAISMGIPVHERIE
CHHHEHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEECCCHHHHHH
ALSLIHDGKRCHGVIARCLVTGELRAYIAKSTTIATGGYGKIYEISTNATICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHH
LDTGIATLGNMEAVQFHPTAIVPAGILTTEGCRGDGGILRDKDGHRFMPDYEPEKKELAS
HHHHHHHHCCCCEEEECCCEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
RDVVSRRMTEHMRKGNGVESPYGPHLWLDITQLGREHIETNLREVKEICDYFLGIDPCKD
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGVRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSVAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCCHHHHHHHHHHH
IGKYVADFCENNDLEIDTALTQKFIDKLQQEIDGLVEGNGTENPFQIKKEMQRIMMNYVG
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
IFRNGPELDKAIKGLKDLLLRAKNLGLKCKKRHANPELVEALRVTRMLKVALTVACGAEA
HHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
RTESRGAHSREDYPQRNDKDWLNRTLATWPDAESLEPVLRYEALDVMKMELPPGYRGYGN
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHEEECCCCCCCCCC
DNTIAHPDTEKRVQEINQVLARLGDDPDRNTLQRALMPYELPSHLQAPNGRLSDTLAITP
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECC
AQPVGNKPL
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]