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The map label for this gene is galK [H]

Identifier: 126175922

GI number: 126175922

Start: 4363388

End: 4364533

Strand: Direct

Name: galK [H]

Synonym: Sbal_3728

Alternate gene names: 126175922

Gene position: 4363388-4364533 (Clockwise)

Preceding gene: 126175921

Following gene: 126175923

Centisome position: 85.1

GC content: 50.26

Gene sequence:

>1146_bases
ATGTCAAACCCTGCGCAGCGCGCCACAAAGTTATTTGTCCAAACCTTTGGCACTAAAGCCGACGATTTATATCAAGCCCC
TGGGCGCGTCAATCTGATCGGTGAATACACGGATTACAACGACGGTTTTGTACTCCCGGCAGCCATTAATTTTCATACAG
TGATTGCGGTAAAACGCCGTGACGACACTAAGTTTCGTGCCGTTGCCGATGCCTTTCCCGGACAAATTAAAGAGTGGACC
TTCGGTCAAGAAAACGACATGGACCCGCAAGATGGCTGGGTGAATTACCTCAAAGGTTTCACTGCGGCTATGGCGCAAAC
GGGTTTATTAGCCAAGGGCTTAGACTTAGCCATTGTGGGCGATGTACCACTTGCGGCGGGGTTATCCTCATCGGGCGCCC
TCGTTGTCGCCTTCGGCACTGCCATCAGTGATACCAGCCAATTGCATTTATCACCAATGGCGGTAGCGCAACTGGCCCAA
CGTGGTGAACACAGATATGTCGAATCGGCCTGTGGCATCATGGATCAAATGTGCAGCGCCATGGGTGAGCAAGACCACGC
ACTGCTGATTGACTGCTTAGATCTCGATAGCGAAGCCATTCCTATCCCAGAAAACCTAAGCCTTATCATCATAGATGCCC
ATATTGAGAAACAACGTTTAGCCGCCACCAATCAACAACGTCGCAACGAATGCGCCCAAGCTGCCGAATACTTTGGCTTA
GATGCGCTGCGTCACCTCGATTTACGTCGATTAGAAAGCGCAAAAGCCGATTTAGATGAAGTGTTATATCGCAGAGCAAA
ACACGTCGTCACAGAAAATCAAAGAACCCAGAGTGCAGCCCGCGCTTTAGAACAAAATAACATTCAAAAATTCAGCCGCT
TAATGGCGGAATCCCATGCTTCACTGCGGGATGATTTTGAAGTGACACTGCCCGAATTTGATACCTTAGTTGAGATTGTC
AGCCAAGTGATTGGCGAGCGTGGCGGCATCCGCATGACCGACGGCTGCGTGGTCGCTTTAGTCGATCATGAACTGACCGA
TGCTGTCGTGGCCGCCGTTGAACATGAGTTTTTCGACAAAACCGCAATTGATGCCACTGTCTATTTATGTTCTGCCAGCG
CTGGCGCGGGCCGCATAGACAATTAG

Upstream 100 bases:

>100_bases
CCATTTCAGCAAAAAATCTCAGTTACATCACCGACTCAGTCGTGATATAAATCGATGACGGTAACGAAATTAGCTCAGCT
TTTTTGGAATTTTTTACAGC

Downstream 100 bases:

>100_bases
CCAGAACAGGCTTAAAACAAAGAAAACCAATACAGTGACAAGGCCGTCGATAACATACGAATTCATCGCTGATGTTTATG
GTGTTGATGGCAAATAATAG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRRDDTKFRAVADAFPGQIKEWT
FGQENDMDPQDGWVNYLKGFTAAMAQTGLLAKGLDLAIVGDVPLAAGLSSSGALVVAFGTAISDTSQLHLSPMAVAQLAQ
RGEHRYVESACGIMDQMCSAMGEQDHALLIDCLDLDSEAIPIPENLSLIIIDAHIEKQRLAATNQQRRNECAQAAEYFGL
DALRHLDLRRLESAKADLDEVLYRRAKHVVTENQRTQSAARALEQNNIQKFSRLMAESHASLRDDFEVTLPEFDTLVEIV
SQVIGERGGIRMTDGCVVALVDHELTDAVVAAVEHEFFDKTAIDATVYLCSASAGAGRIDN

Sequences:

>Translated_381_residues
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRRDDTKFRAVADAFPGQIKEWT
FGQENDMDPQDGWVNYLKGFTAAMAQTGLLAKGLDLAIVGDVPLAAGLSSSGALVVAFGTAISDTSQLHLSPMAVAQLAQ
RGEHRYVESACGIMDQMCSAMGEQDHALLIDCLDLDSEAIPIPENLSLIIIDAHIEKQRLAATNQQRRNECAQAAEYFGL
DALRHLDLRRLESAKADLDEVLYRRAKHVVTENQRTQSAARALEQNNIQKFSRLMAESHASLRDDFEVTLPEFDTLVEIV
SQVIGERGGIRMTDGCVVALVDHELTDAVVAAVEHEFFDKTAIDATVYLCSASAGAGRIDN
>Mature_380_residues
SNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRRDDTKFRAVADAFPGQIKEWTF
GQENDMDPQDGWVNYLKGFTAAMAQTGLLAKGLDLAIVGDVPLAAGLSSSGALVVAFGTAISDTSQLHLSPMAVAQLAQR
GEHRYVESACGIMDQMCSAMGEQDHALLIDCLDLDSEAIPIPENLSLIIIDAHIEKQRLAATNQQRRNECAQAAEYFGLD
ALRHLDLRRLESAKADLDEVLYRRAKHVVTENQRTQSAARALEQNNIQKFSRLMAESHASLRDDFEVTLPEFDTLVEIVS
QVIGERGGIRMTDGCVVALVDHELTDAVVAAVEHEFFDKTAIDATVYLCSASAGAGRIDN

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=381, Percent_Identity=37.007874015748, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI48527957, Length=418, Percent_Identity=26.7942583732057, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4503897, Length=418, Percent_Identity=26.7942583732057, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786972, Length=377, Percent_Identity=42.9708222811671, Blast_Score=326, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71989053, Length=414, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319494, Length=201, Percent_Identity=33.8308457711443, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=29.045643153527, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24661292, Length=432, Percent_Identity=25.462962962963, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21355577, Length=432, Percent_Identity=25.462962962963, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24661285, Length=432, Percent_Identity=25.462962962963, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41644; Mature: 41513

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRR
CCCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEECEEEEEEEEEC
DDTKFRAVADAFPGQIKEWTFGQENDMDPQDGWVNYLKGFTAAMAQTGLLAKGLDLAIVG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCCCEEEEC
DVPLAAGLSSSGALVVAFGTAISDTSQLHLSPMAVAQLAQRGEHRYVESACGIMDQMCSA
CCCHHCCCCCCCCEEEEECCCCCCCCCEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MGEQDHALLIDCLDLDSEAIPIPENLSLIIIDAHIEKQRLAATNQQRRNECAQAAEYFGL
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALRHLDLRRLESAKADLDEVLYRRAKHVVTENQRTQSAARALEQNNIQKFSRLMAESHA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
SLRDDFEVTLPEFDTLVEIVSQVIGERGGIRMTDGCVVALVDHELTDAVVAAVEHEFFDK
HHCCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHH
TAIDATVYLCSASAGAGRIDN
HHHHHEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SNPAQRATKLFVQTFGTKADDLYQAPGRVNLIGEYTDYNDGFVLPAAINFHTVIAVKRR
CCHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCEEEEEEECEEEEEEEEEC
DDTKFRAVADAFPGQIKEWTFGQENDMDPQDGWVNYLKGFTAAMAQTGLLAKGLDLAIVG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHCCCCEEEEC
DVPLAAGLSSSGALVVAFGTAISDTSQLHLSPMAVAQLAQRGEHRYVESACGIMDQMCSA
CCCHHCCCCCCCCEEEEECCCCCCCCCEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MGEQDHALLIDCLDLDSEAIPIPENLSLIIIDAHIEKQRLAATNQQRRNECAQAAEYFGL
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALRHLDLRRLESAKADLDEVLYRRAKHVVTENQRTQSAARALEQNNIQKFSRLMAESHA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
SLRDDFEVTLPEFDTLVEIVSQVIGERGGIRMTDGCVVALVDHELTDAVVAAVEHEFFDK
HHCCCCEEECCCHHHHHHHHHHHHCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHH
TAIDATVYLCSASAGAGRIDN
HHHHHEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA