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The map label for this gene is kefC [H]

Identifier: 126175921

GI number: 126175921

Start: 4361437

End: 4363092

Strand: Direct

Name: kefC [H]

Synonym: Sbal_3727

Alternate gene names: 126175921

Gene position: 4361437-4363092 (Clockwise)

Preceding gene: 126175920

Following gene: 126175922

Centisome position: 85.06

GC content: 49.28

Gene sequence:

>1656_bases
ATGGAACCCGGTATCCTCATTATCACACTCATCTGCGGCATGCTCGTCAGCCGTATAGGACTGCCACCGCTCATCGGCTA
CTTAGTGGCGGGCTTTGTACTATTCGTCCTCGGGATAGATAAAGAAAGCCTGCCATTGCTGCAAGAACTCGCAAGCCTAG
GCGTGACTTTGCTGCTGTTTGCTATTGGTTTGAAACTCGATATTCGTAGCCTGTTCAAGGCCGAAGTGTGGGCGGGTTCG
AGTGTCCACTTAGTTCTCTCAATTGTCGTTTTTGTGCCGATTCTGAAACTCTTCGGCTTACTGGGTTTAAGCCAACTCAC
GAGTCTTAACCTTGAGCAACTGACGTTAATCGCCTTCGCGTTAAGCTTCTCCAGTACAGTATTTGCGGTCAAAGTGTTAG
AAGATAAGGGCGATGTCCAATCCCTCTACGGCCGGGTCGCCATTGGTATCTTGATTATGCAGGATATCTTCGCCGTACTG
TTTTTAACGATTTCTAAGGGCGATGTACCTTCGGTATGGGCCTTCGCATTACTCTTACTGCCACTGGCTAAGCCTCTCAT
TTATAAAGCCTTCGACCGTGTCGGCCACGGTGAACTGTTAGTCCTTTTCGGCCTAGTGATGGCACTTGTGGTTGGCGCTT
GGTTATTTGAATCTGTTGGCCTGAAACCCGATCTCGGCGCACTGATCATAGGTATCTTGTTGGCGGGCCACAAAAAGTCC
TCAGAGCTGGCAAAATCCCTGTTCTATTTTAAAGAACTCTTCCTCGTGGCCTTCTTCTTAACGATTGGTCTCAACGGTTT
ACCTACGGTATCGGATATCGTTCTCGCAGCACTGTTAGTGCTGCTAGTACCACTTAAAATCCTGCTGTTTGTTTACATTC
TTACCCGCTTTAAGCTGCGTTCACGTACCTCTATGTTGGGCTCGTTCAACCTAGGTAACTTCAGTGAATTCGGTTTAATT
GTCGCTGCCGTCGCCACCTATAAAGGTTGGTTGCCTCCCGAGTGGCTAGTGATCATCGCCGTGGCATTAAGCTTTAGCTT
TTTACTCGCCGCGCCGCTTAACGCTACCGTCGGTAACATATATCAACGATTCCAGCAGCGTTTAATCAAGCTTGAAAAAC
GCCCATTGCACCCAGAAGACAGACCGATCGCCATTGGCAACCCACGCTTCTTAATCTTAGGTATGGGCCGCATTGGTAGC
GGCGCCTACGATGAACTCAGGGAACAATTTGACGGCGAAATTCTCGGCATTGAGCACAAGCAAGACTTAGTCGATTTACA
CAAAGCCAAGGGCCGCAACGTAGTGCAAGGTGACGCCGCGGATACCGACTTTTGGGAGAAACTCGACAGAGCGCCTAACC
TTGAGTTAGTGCTGCTGGCCATGCCGCACCACGCGGGAAATATGTTTGCGGTTGAGCAACTCAAAAAACTGAATTATCAA
GGCAAGATCAGTGCGATTGTGCAGTACAGTGACGATGCCGCGGCACTTCGCGAATCGGGCGTACACAGTGTTTACAACCT
GTACGAAGCTGCGGGTGCCGGTTTTGTGGATCATGTGATTTACGAGCTGTTGCAAGACTCAGAGAAAAACGCCGCGCAAG
CGGAAGAAATAGCGCAAGTGGCTGATCCTAAAATTAATGCCGAGTCCAATAGTTAA

Upstream 100 bases:

>100_bases
GAAAGCGGACTTTTTTCATTAAAAGTCCGCTTTTTTGTTCCAGTGTCATAGATTTCTTATACAATCACTCATAATTTTGG
ACTTTTTAGATTGGAGCATC

Downstream 100 bases:

>100_bases
GTGCCTGCTAATGCTGCATTGAATTAAAATCACGCCATAATAGGCCGCACAAACGAGCAGTAACTTCCTCTGCAAGTTTG
TGCGGCCTCCAACTAACTAC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MEPGILIITLICGMLVSRIGLPPLIGYLVAGFVLFVLGIDKESLPLLQELASLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SVHLVLSIVVFVPILKLFGLLGLSQLTSLNLEQLTLIAFALSFSSTVFAVKVLEDKGDVQSLYGRVAIGILIMQDIFAVL
FLTISKGDVPSVWAFALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKS
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDIVLAALLVLLVPLKILLFVYILTRFKLRSRTSMLGSFNLGNFSEFGLI
VAAVATYKGWLPPEWLVIIAVALSFSFLLAAPLNATVGNIYQRFQQRLIKLEKRPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELREQFDGEILGIEHKQDLVDLHKAKGRNVVQGDAADTDFWEKLDRAPNLELVLLAMPHHAGNMFAVEQLKKLNYQ
GKISAIVQYSDDAAALRESGVHSVYNLYEAAGAGFVDHVIYELLQDSEKNAAQAEEIAQVADPKINAESNS

Sequences:

>Translated_551_residues
MEPGILIITLICGMLVSRIGLPPLIGYLVAGFVLFVLGIDKESLPLLQELASLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SVHLVLSIVVFVPILKLFGLLGLSQLTSLNLEQLTLIAFALSFSSTVFAVKVLEDKGDVQSLYGRVAIGILIMQDIFAVL
FLTISKGDVPSVWAFALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKS
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDIVLAALLVLLVPLKILLFVYILTRFKLRSRTSMLGSFNLGNFSEFGLI
VAAVATYKGWLPPEWLVIIAVALSFSFLLAAPLNATVGNIYQRFQQRLIKLEKRPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELREQFDGEILGIEHKQDLVDLHKAKGRNVVQGDAADTDFWEKLDRAPNLELVLLAMPHHAGNMFAVEQLKKLNYQ
GKISAIVQYSDDAAALRESGVHSVYNLYEAAGAGFVDHVIYELLQDSEKNAAQAEEIAQVADPKINAESNS
>Mature_551_residues
MEPGILIITLICGMLVSRIGLPPLIGYLVAGFVLFVLGIDKESLPLLQELASLGVTLLLFAIGLKLDIRSLFKAEVWAGS
SVHLVLSIVVFVPILKLFGLLGLSQLTSLNLEQLTLIAFALSFSSTVFAVKVLEDKGDVQSLYGRVAIGILIMQDIFAVL
FLTISKGDVPSVWAFALLLLPLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKS
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDIVLAALLVLLVPLKILLFVYILTRFKLRSRTSMLGSFNLGNFSEFGLI
VAAVATYKGWLPPEWLVIIAVALSFSFLLAAPLNATVGNIYQRFQQRLIKLEKRPLHPEDRPIAIGNPRFLILGMGRIGS
GAYDELREQFDGEILGIEHKQDLVDLHKAKGRNVVQGDAADTDFWEKLDRAPNLELVLLAMPHHAGNMFAVEQLKKLNYQ
GKISAIVQYSDDAAALRESGVHSVYNLYEAAGAGFVDHVIYELLQDSEKNAAQAEEIAQVADPKINAESNS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG4651

COG function: function code P; Kef-type K+ transport system, predicted NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=378, Percent_Identity=26.1904761904762, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786232, Length=523, Percent_Identity=27.7246653919694, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786685, Length=536, Percent_Identity=26.3059701492537, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789749, Length=454, Percent_Identity=25.1101321585903, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 60170; Mature: 60170

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGILIITLICGMLVSRIGLPPLIGYLVAGFVLFVLGIDKESLPLLQELASLGVTLLLF
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGSSVHLVLSIVVFVPILKLFGLLGLSQLTSLNLEQLTLIAFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSFSSTVFAVKVLEDKGDVQSLYGRVAIGILIMQDIFAVLFLTISKGDVPSVWAFALLLL
HHHCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
PLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCH
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDIVLAALLVLLVPLKILLFVYILTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLGSFNLGNFSEFGLIVAAVATYKGWLPPEWLVIIAVALSFSFLLAAPLNATVGNI
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
YQRFQQRLIKLEKRPLHPEDRPIAIGNPRFLILGMGRIGSGAYDELREQFDGEILGIEHK
HHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCCH
QDLVDLHKAKGRNVVQGDAADTDFWEKLDRAPNLELVLLAMPHHAGNMFAVEQLKKLNYQ
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
GKISAIVQYSDDAAALRESGVHSVYNLYEAAGAGFVDHVIYELLQDSEKNAAQAEEIAQV
CCEEEEEEECCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ADPKINAESNS
HCCCCCCCCCC
>Mature Secondary Structure
MEPGILIITLICGMLVSRIGLPPLIGYLVAGFVLFVLGIDKESLPLLQELASLGVTLLLF
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGSSVHLVLSIVVFVPILKLFGLLGLSQLTSLNLEQLTLIAFA
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LSFSSTVFAVKVLEDKGDVQSLYGRVAIGILIMQDIFAVLFLTISKGDVPSVWAFALLLL
HHHCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
PLAKPLIYKAFDRVGHGELLVLFGLVMALVVGAWLFESVGLKPDLGALIIGILLAGHKKS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCH
SELAKSLFYFKELFLVAFFLTIGLNGLPTVSDIVLAALLVLLVPLKILLFVYILTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLGSFNLGNFSEFGLIVAAVATYKGWLPPEWLVIIAVALSFSFLLAAPLNATVGNI
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
YQRFQQRLIKLEKRPLHPEDRPIAIGNPRFLILGMGRIGSGAYDELREQFDGEILGIEHK
HHHHHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCCH
QDLVDLHKAKGRNVVQGDAADTDFWEKLDRAPNLELVLLAMPHHAGNMFAVEQLKKLNYQ
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCC
GKISAIVQYSDDAAALRESGVHSVYNLYEAAGAGFVDHVIYELLQDSEKNAAQAEEIAQV
CCEEEEEEECCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
ADPKINAESNS
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA