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The map label for this gene is parC [H]

Identifier: 126175767

GI number: 126175767

Start: 4196513

End: 4198789

Strand: Reverse

Name: parC [H]

Synonym: Sbal_3571

Alternate gene names: 126175767

Gene position: 4198789-4196513 (Counterclockwise)

Preceding gene: 126175768

Following gene: 126175764

Centisome position: 81.89

GC content: 48.66

Gene sequence:

>2277_bases
ATGAGTGACGCTATCAAGTTAAGTCTCGATGGGGTAGAGCAAATGCCATTACGGCGCTTTACCGAAGAGGCTTATCTGAA
CTATTCCATGTACGTCATTATGGACCGAGCCCTGCCACACATTGGTGATGGGCTTAAACCGGTACAGCGTCGAATTATCT
ATGCGATGAGTGAGTTAGGTTTATCGGCTCAATCTAAGCATAAAAAGTCGGCACGTACGGTTGGTGACGTATTAGGTAAA
TACCATCCCCACGGCGATAGTGCCTGTTATGAGGCTATGGTATTGATGGCGCAGCCATTCTCTTATCGCTATCCGTTAGT
CGATGGTCAAGGTAACTGGGGGGCGCCCGATGATCCTAAGTCATTTGCGGCCATGCGTTACACCGAAGCGCGTTTATCTA
AATTCTCAGAAGTGCTGCTCAGCGAACTGGGACAAGGTACGGTCGAGTGGGGCGCTAACTTTGATGGCACGTTAAAAGAG
CCAAAAGTATTGCCGGCACGTTTACCGCATATTTTACTCAATGGCATTACCGGTATTGCCGTGGGCATGGCGACGGATAT
TCCGCCGCATAACGTCAGGGAATTAGTCTCGGCCTGCGTAGCATTGCTTGATGATCCTAAGCTTGAACTCGAGCAATTGA
TGGCCTTTGTACCTGGGCCTGATTATCCGACCGAAGCCGAGATCATTACCCCGTCTGCCGATATTGCAAAAATTTATGAA
TCGGGCCGTGGGTCATTAAGAGCGCGCGCAGTTTATACAGTCGATGGTGGTGAAATCATCATCACGGCGCTGCCGCATCA
AGCCAGTAGCGGGAAAATTTTAGAGCAAATTGCCGGTCAAATGCAGGCGAAGAAATTGCCTATGGTGGCCGATTTACGCG
ATGAATCGGATCATGAAAACCCAGTGCGGCTGGTGGTCGTGCCGCGCTCAAATCGTGTCGATTGCGATCAGTTAATGGCG
CATTTGTTTGCTACCACGGATTTAGAAAAGAGCTTTAGAGTTAACTTAAACGTGCTGGGTCTCGATGGCCGTCCACGGGT
TAAAGGGCTAAAAACCTTATTAACTGAGTGGTTAGAGTTCCGCGTTGATACGGTTAAACGTCGTTTGGAATACCGTTTAG
ATAAAGTCGTATCGCGGTTACACATACTCGAAGCGTTAATGATCGCTTTCCTCAACATTGATGAAGTGATTGAGATTATT
CGTTTTCACGATGAGCCTAAAGCCGAGTTAATGGCCCGTTTCTCACTCAGTGATAAACAAGCCGAATCGATCCTCGAGTT
AAAGTTACGTCATTTAGCTAAGTTAGAAGAATTTAAGATCACGGCAGAGCAGAATGAGCTTGAAGCCGAGCGCGAGAAAC
TCGAGCAGTTATTGGGTTCAGAGCGTCGCTTGAAGACCTTGATCAAAAAAGAATTAATTCAAGATGCCGAAACCTACGGT
GATGATCGTCGCTCTCCAATAGTGCTGCGCAACGAGTCTCGCGCCTTAACGGAACAAGAGTTAACGCCGACTGAGGCTGT
GACAGTGGTCTTGTCTGAAAAAGGCTGGGTGCGTTGTGCTAAGGGCCATGATATCGATCCGTTATCGCTCTCCTATAAGT
CTGGCGACCAATACTTGTGCAGTGCCATAGGGCGTAGTAATCAGGCGGCTGTGTTTATTGATTCGTCTGGGCGGGCATTT
GCGACCGACAGTCATACTTTACCATCGGCACGCAGCCAAGGTGAGCCTATCACGACTCGCTTCAATATGGCGCCTGGCGA
AACCATGCAGCATGTATTGATGGGTGAGGAAGACCAATGTTACCTGTTGGCAACTGACGCGGGTTACGGTTTTATTTGCT
CGTACAATGATATGGTGTCGCGCAATAAGGCGGGTAAGGCCTTGCTGAGTTTGCCGACAAACGCTAAGTCATTAACGCCT
AAGTTGATTGATCGCACGAAGGAAATGTCGCTCTTGGCGATCACGAACGAAGGTCGAATGTTGTTGTTCTCCCTTGAAGC
CTTACCGCAATTATCTAAGGGGAAAGGTAACAAGATTATCGGCATTCCTACGGAAAGAGCCAAGAACCGTGAAGAGCTGA
TGACGCACTTACAATTAGTGCCGAGTGATACGCCAGTCACCTTGTGGGCGGGTAAGCGCAAACTCACACTTAAGCCTAGC
GATCTTGAGCATTATCGTGGAGAACGTGGTCGTCGTGGCGCTAAGTTGCCTAGAGGCTTACAACGTGTCGATAGCGTTGA
ATTAGGTGACGGCGGCGAGCCATTACCGAGCATTTAA

Upstream 100 bases:

>100_bases
GCCGACGGTGCTATGTACATTTCAGATGATTTAAAAGGTAACGTGTATCGCTTGTTCTACAAGGGCGATAGTACTGAAGA
ACCACAGGAACTAGAAGAAA

Downstream 100 bases:

>100_bases
TATTTTGATGGACTCAATGCTATAAAGCATTGAAGACATAAATGAAAGCCACCTGAGTTTACTTGGTGGCTTTTTTGTTT
TTATCGCCTGAGTCTCGACT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKE
PKVLPARLPHILLNGITGIAVGMATDIPPHNVRELVSACVALLDDPKLELEQLMAFVPGPDYPTEAEIITPSADIAKIYE
SGRGSLRARAVYTVDGGEIIITALPHQASSGKILEQIAGQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMA
HLFATTDLEKSFRVNLNVLGLDGRPRVKGLKTLLTEWLEFRVDTVKRRLEYRLDKVVSRLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFSLSDKQAESILELKLRHLAKLEEFKITAEQNELEAEREKLEQLLGSERRLKTLIKKELIQDAETYG
DDRRSPIVLRNESRALTEQELTPTEAVTVVLSEKGWVRCAKGHDIDPLSLSYKSGDQYLCSAIGRSNQAAVFIDSSGRAF
ATDSHTLPSARSQGEPITTRFNMAPGETMQHVLMGEEDQCYLLATDAGYGFICSYNDMVSRNKAGKALLSLPTNAKSLTP
KLIDRTKEMSLLAITNEGRMLLFSLEALPQLSKGKGNKIIGIPTERAKNREELMTHLQLVPSDTPVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGGEPLPSI

Sequences:

>Translated_758_residues
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKE
PKVLPARLPHILLNGITGIAVGMATDIPPHNVRELVSACVALLDDPKLELEQLMAFVPGPDYPTEAEIITPSADIAKIYE
SGRGSLRARAVYTVDGGEIIITALPHQASSGKILEQIAGQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMA
HLFATTDLEKSFRVNLNVLGLDGRPRVKGLKTLLTEWLEFRVDTVKRRLEYRLDKVVSRLHILEALMIAFLNIDEVIEII
RFHDEPKAELMARFSLSDKQAESILELKLRHLAKLEEFKITAEQNELEAEREKLEQLLGSERRLKTLIKKELIQDAETYG
DDRRSPIVLRNESRALTEQELTPTEAVTVVLSEKGWVRCAKGHDIDPLSLSYKSGDQYLCSAIGRSNQAAVFIDSSGRAF
ATDSHTLPSARSQGEPITTRFNMAPGETMQHVLMGEEDQCYLLATDAGYGFICSYNDMVSRNKAGKALLSLPTNAKSLTP
KLIDRTKEMSLLAITNEGRMLLFSLEALPQLSKGKGNKIIGIPTERAKNREELMTHLQLVPSDTPVTLWAGKRKLTLKPS
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGGEPLPSI
>Mature_757_residues
SDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELGLSAQSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEP
KVLPARLPHILLNGITGIAVGMATDIPPHNVRELVSACVALLDDPKLELEQLMAFVPGPDYPTEAEIITPSADIAKIYES
GRGSLRARAVYTVDGGEIIITALPHQASSGKILEQIAGQMQAKKLPMVADLRDESDHENPVRLVVVPRSNRVDCDQLMAH
LFATTDLEKSFRVNLNVLGLDGRPRVKGLKTLLTEWLEFRVDTVKRRLEYRLDKVVSRLHILEALMIAFLNIDEVIEIIR
FHDEPKAELMARFSLSDKQAESILELKLRHLAKLEEFKITAEQNELEAEREKLEQLLGSERRLKTLIKKELIQDAETYGD
DRRSPIVLRNESRALTEQELTPTEAVTVVLSEKGWVRCAKGHDIDPLSLSYKSGDQYLCSAIGRSNQAAVFIDSSGRAFA
TDSHTLPSARSQGEPITTRFNMAPGETMQHVLMGEEDQCYLLATDAGYGFICSYNDMVSRNKAGKALLSLPTNAKSLTPK
LIDRTKEMSLLAITNEGRMLLFSLEALPQLSKGKGNKIIGIPTERAKNREELMTHLQLVPSDTPVTLWAGKRKLTLKPSD
LEHYRGERGRRGAKLPRGLQRVDSVELGDGGEPLPSI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=66.8470906630582, Blast_Score=1043, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=713, Percent_Identity=36.3253856942497, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=510, Percent_Identity=23.7254901960784, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=306, Percent_Identity=25.4901960784314, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84396; Mature: 84265

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCCEEEECCCCHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEPKVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHH
VGMATDIPPHNVRELVSACVALLDDPKLELEQLMAFVPGPDYPTEAEIITPSADIAKIYE
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
SGRGSLRARAVYTVDGGEIIITALPHQASSGKILEQIAGQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVVVPRSNRVDCDQLMAHLFATTDLEKSFRVNLNVLGLDGRPRVKGLKTLLTEWLEF
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RVDTVKRRLEYRLDKVVSRLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFSLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCHHH
AESILELKLRHLAKLEEFKITAEQNELEAEREKLEQLLGSERRLKTLIKKELIQDAETYG
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DDRRSPIVLRNESRALTEQELTPTEAVTVVLSEKGWVRCAKGHDIDPLSLSYKSGDQYLC
CCCCCCEEEECCCCCCHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCEEECCCCCHHHH
SAIGRSNQAAVFIDSSGRAFATDSHTLPSARSQGEPITTRFNMAPGETMQHVLMGEEDQC
HHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCE
YLLATDAGYGFICSYNDMVSRNKAGKALLSLPTNAKSLTPKLIDRTKEMSLLAITNEGRM
EEEEECCCCEEEEECHHHHHCCCCCCEEEECCCCCHHCCHHHHHHHHCCEEEEEECCCCE
LLFSLEALPQLSKGKGNKIIGIPTERAKNREELMTHLQLVPSDTPVTLWAGKRKLTLKPS
EEEEHHHCCCCCCCCCCEEEECCCHHHCCHHHHHHHHHCCCCCCCEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGGEPLPSI
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCCC
>Mature Secondary Structure 
SDAIKLSLDGVEQMPLRRFTEEAYLNYSMYVIMDRALPHIGDGLKPVQRRIIYAMSELG
CCCEEEECCCCHHHHHHHHHHHHHHCEEEEEEEEHHCHHCCCCHHHHHHHHHHHHHHHC
LSAQSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPK
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCH
SFAAMRYTEARLSKFSEVLLSELGQGTVEWGANFDGTLKEPKVLPARLPHILLNGITGIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHH
VGMATDIPPHNVRELVSACVALLDDPKLELEQLMAFVPGPDYPTEAEIITPSADIAKIYE
HHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
SGRGSLRARAVYTVDGGEIIITALPHQASSGKILEQIAGQMQAKKLPMVADLRDESDHEN
CCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
PVRLVVVPRSNRVDCDQLMAHLFATTDLEKSFRVNLNVLGLDGRPRVKGLKTLLTEWLEF
CEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
RVDTVKRRLEYRLDKVVSRLHILEALMIAFLNIDEVIEIIRFHDEPKAELMARFSLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCHHH
AESILELKLRHLAKLEEFKITAEQNELEAEREKLEQLLGSERRLKTLIKKELIQDAETYG
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
DDRRSPIVLRNESRALTEQELTPTEAVTVVLSEKGWVRCAKGHDIDPLSLSYKSGDQYLC
CCCCCCEEEECCCCCCHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCEEECCCCCHHHH
SAIGRSNQAAVFIDSSGRAFATDSHTLPSARSQGEPITTRFNMAPGETMQHVLMGEEDQC
HHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCE
YLLATDAGYGFICSYNDMVSRNKAGKALLSLPTNAKSLTPKLIDRTKEMSLLAITNEGRM
EEEEECCCCEEEEECHHHHHCCCCCCEEEECCCCCHHCCHHHHHHHHCCEEEEEECCCCE
LLFSLEALPQLSKGKGNKIIGIPTERAKNREELMTHLQLVPSDTPVTLWAGKRKLTLKPS
EEEEHHHCCCCCCCCCCEEEECCCHHHCCHHHHHHHHHCCCCCCCEEEEECCEEEEECCC
DLEHYRGERGRRGAKLPRGLQRVDSVELGDGGEPLPSI
HHHHHCCCCCCCCCCCHHHHHHHCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]