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The map label for this gene is yngE [H]

Identifier: 126175034

GI number: 126175034

Start: 3329318

End: 3330925

Strand: Direct

Name: yngE [H]

Synonym: Sbal_2829

Alternate gene names: 126175034

Gene position: 3329318-3330925 (Clockwise)

Preceding gene: 126175033

Following gene: 126175035

Centisome position: 64.93

GC content: 53.05

Gene sequence:

>1608_bases
GTGACGCAAATAAGCAGTCGTATCAACGCCCGTAGCGATGAATTTAAAGCAAAATCCGACGATATGGCCGCTCTAGTGGC
CGATCTTAAAACTAAACTCAATAAAATCGAACTCGGCGGCGGCCCTGTGGCGCTGGAGCGTCATTTATCCCGCGGTAAAT
TACTGCCACGTCAACGAGTTGAAAAGCTACTCGATGCGGGCTCGCCCTTTTTAGAACTGTCGCAATTTGCGGCGTTTGAA
GTCTACGACGAAGAAGTGCCCGCAGCGGGCATTATTGCCGGTATCGGCCGTGTGAGTGGCGTGGAATGCATGATCATCGC
CAACGACGCCACAGTGAAAGGCGGCACTTACTACCCGATTACCGTCAAAAAACACCTTCGCGCCCAAGATATTGCCAGCC
GTTGTCACTTGCCTTGTATTTATTTAGTCGACTCGGGCGGCGCTAACCTGCCCCGCCAAGATGAAGTGTTCCCCGACCGC
GACCATTTCGGCCGCATCTTTTACAACCAAGCGCAAATGTCCGCCAAAGGTATCCCACAAATCGCTGTGGTGATGGGTTT
ATGTACCGCGGGCGGCGCTTATGTGCCTGCCATGGCGGATGAATCCATTATCGTAAAAGATCAAGGCACTATCTTCTTAG
CAGGCCCGCCATTAGTGAAAGCGGCAACTGGCGAAGAAGTTAGCGCCGAAGAACTGGGCGGCGCCGAAGTGCACACCAAA
ATTTCCGGCGTGGCGGACCATTTAGCCCAAAACGATGAGCACGCGCTGGAGCTTGCCCGCCGCGCCGTATCACGCCTGAA
TCATCAAAAAGAAATCAAATCACTCCTAAGCCCAGTCAAACCGCCGAAGTTCGACATTAGCGAACTGTACGGCATTGTCG
GCACCGACTTGAAAAAGCCCTTTGATGTAAAGGAAGTGATCGCCCGTATCGTCGATGATTCTGATTTTGATGAATTTAAA
GCCAACTATGGCGCAACCTTAGTGTGCGGTTTTGCCCGAATTCACGGCTATCCTGTCGGCATCGTCGCCAACAACGGCAT
TTTGTTCTCAGAGTCGGCGCAAAAAGGCGCACACTTTATTGAACTATGCTGCCAGCGCAAAATTCCGCTGCTGTTCCTGC
AAAACATCACCGGCTTTATGGTGGGAAAAAAGTACGAACACGAAGGCATAGCCAAACACGGCGCTAAGATGGTGACCGCC
GTTTCTTGCGCCAATGTGCCTAAATTCACTGTCATTATCGGCGGCAGCTACGGCGCGGGTAACTACGGTATGTGTGGCCG
CGCGTTCGAACCGACCATGATGTGGATGTGGCCTAACGCCCGTATCTCTGTGATGGGCGGCGAGCAAGCAGCTGGCGTAC
TAGCCACAGTGCGCCGCGACGGTTTGGCCCGCAAAGGTGAAGAATGGTCATTAGAGGATGAAAAAGCCTTTAAAGCGCCG
ATTGTCGCCCAGTACGACAAAGAAGGTCATCCGTATCATGCCAGCGCCCGTTTATGGGATGACGGCATTATCGACCCAGC
GCAAACCCGCGATGTAGTTGGCCTTGCCCTATCGGCGGCGTTAAACGCCCCTATCGAAGACACCCGCTTTGGTGTGTTCC
GTATGTAA

Upstream 100 bases:

>100_bases
CTCTCACAAGTGAATGGGTAGCACCTCACTGTAACTTACAGTTTGCGCCACCCATTCGAGCAAGGTGATACCGAGTTTCC
GCTTTATAAGGACAATCAAA

Downstream 100 bases:

>100_bases
AGGCACATGTGAAAAACATATGCCACACAATAAGATAGGGGAAAGAATAATGACAGACAGATTAAACAGCACTAGCGGCA
CAAAGGATTTAAGCAACTTG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSLEDEKAFKAP
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Sequences:

>Translated_535_residues
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFE
VYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDR
DHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFK
ANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTA
VSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSLEDEKAFKAP
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
>Mature_534_residues
TQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRVEKLLDAGSPFLELSQFAAFEV
YDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPITVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRD
HFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTKI
SGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKPFDVKEVIARIVDDSDFDEFKA
NYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAV
SCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSLEDEKAFKAPI
VAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=522, Percent_Identity=69.9233716475096, Blast_Score=747, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=498, Percent_Identity=33.1325301204819, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI295821216, Length=518, Percent_Identity=32.046332046332, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI310133460, Length=132, Percent_Identity=64.3939393939394, Blast_Score=159, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.6022514071295, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=493, Percent_Identity=32.8600405679513, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=493, Percent_Identity=32.8600405679513, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=65.9380692167577, Blast_Score=746, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57972; Mature: 57841

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRV
CCCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCCEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCCHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSLEDEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCC
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
CEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC
>Mature Secondary Structure 
TQISSRINARSDEFKAKSDDMAALVADLKTKLNKIELGGGPVALERHLSRGKLLPRQRV
CCCHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCEEECCCCCHHHHHHHHCCCCCCHHHH
EKLLDAGSPFLELSQFAAFEVYDEEVPAAGIIAGIGRVSGVECMIIANDATVKGGTYYPI
HHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQDIASRCHLPCIYLVDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCEEEEHHHHCCCCCCH
IAVVMGLCTAGGAYVPAMADESIIVKDQGTIFLAGPPLVKAATGEEVSAEELGGAEVHTK
HHHHHHHHHCCCCEEECCCCCEEEEECCCEEEEECCCEEEECCCCCCCHHHCCCCHHHHH
ISGVADHLAQNDEHALELARRAVSRLNHQKEIKSLLSPVKPPKFDISELYGIVGTDLKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
FDVKEVIARIVDDSDFDEFKANYGATLVCGFARIHGYPVGIVANNGILFSESAQKGAHFI
CCHHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHCCEEEEEEECCCEEEECCHHHHHHHH
ELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAG
HHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCCHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVRRDGLARKGEEWSLEDEKAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCC
IVAQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTRFGVFRM
CEEEECCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]