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The map label for this gene is ada [H]

Identifier: 126175007

GI number: 126175007

Start: 3288189

End: 3289886

Strand: Reverse

Name: ada [H]

Synonym: Sbal_2800

Alternate gene names: 126175007

Gene position: 3289886-3288189 (Counterclockwise)

Preceding gene: 126175009

Following gene: 126175006

Centisome position: 64.16

GC content: 49.18

Gene sequence:

>1698_bases
ATGAGTACAGATAGAGCGTCTGAGAGTGCGATTAAGCGTGATGAAATAGACTCAGTGCATTCACTGGAGTCAAGTGCTGG
GCTACTTTCTGCGTCCATTTGCCGTGAGGCTAGGATGAGCCGCGATCCGCGTTTTGATGGTAAGTTTTTTGTGGGGGTAT
TAACGACGGGCATTTATTGCCGTACCGTGTGTCCCGCCGTCGCGCCAAAAGAGCAGAATGTGCGTTATTTTGATTCGGCC
GTGAAAGCCGCACAGGCGGGATTGCGCCCGTGTTTGCGTTGTCGGCCCGACAGTGCGCCAGGTTCAAATCCGTGGAAAGG
CACTGGCACAACGTTGGCGAGGGCCATTAGTTTAATTGAAGCGGGTGCCTTAGCGGGGAAATCATCGGGAGAGCCAGCGT
CGACTGTGACACAATTGGCTGACAGATTAGGGATCAGTAGTCGTTATCTTAATAAGCTCTTTACCGAAGGTTTTGGCACT
TCGCCTAAACAATATGCCTTATACAGGCAGTTACTGTTTGCAAAACAACTGCTACATCAAACCCAATTACCTATCACCCA
AGTCGCGCTGGCGGCGGGTTTCAATAGTATTCGCCGTTTCAATGAGGCATTTAAGCAAACTTTACAATTGACGCCAACTC
AATTAAGAAAGACCGCTTTAACCAAGGCGTCAAAGGAGCATGTTGTTGGACGAACAACAGGATTAGGTGAAATTGATACT
ATGGGTGAATTTGTGCCGCACTATGGATTAACCCTATATCAATACTATCGACCCCCATTAGATTGGGCATCGCAGCTGGC
ATTTTATCGCTTACGTGCGGTGACGGGGATGGAGTGGTTCACGCCGCAAATGAGTCATCCACAAGCGAGTGATGCTGTTC
AGGTTGCAGATGAAGCGAACCTTGCCGCTGAAGCCAATGCTGACGATAACGGGCTCGAATATGGTCGCTGTTTTGCCATA
GGCAAGATGCGCGGCACAGTGCAAATTATCCATGAGCCTAAGCTGAATCGCTTCAAACTTGCGATTGCTTTGACCGAAGA
TTCCGCCGTCGATGAGCTGCAATTGCTAGTCACTGAGGTGCGACGTATTTTAGATCTCGATGCGGATATGCAGCAGATTG
AGCAAGGTTTAAGTACGCTGCCGAGTTTAGGTTTAATGCCGTTTTCGGGATTGCGCATTCCTGGCGCAGGATCTTTGTTT
GAAGCGGTTTGCCGCGCGATCTTGGGTCAGCAAGTGACGGTCGTGCAGGCGACTAAGCTACTGAATATATTGGTTGAAGC
CTATGGCGAGTGTTTTAGTCTCAATGGCCGCGAGTATCGATTATTCCCAACACCCGAGGCGATTCGTGAGGCGAGTTTAA
CTGAGCTAAAAATGCCGGGCGCCCGTAAATTAGCGCTCAATGCGCTCGCGGCGTTTATCTGCGAACATCCTGAGGCAAGT
GTCGATGATTGGCTCAGCGTTAAAGGCATAGGTCCTTGGACGATAGCGTATGCCAAGCTTCGTGGCTTGGGCGATCCAAA
CGTGTTTTTGCATTTGGATTTGATTGTTAAAAAGCATTTATTGGCCTTATATATCAAGAACAATAGGTTGGATGAAACGG
CCGCTGCGGCAGTGATCTATTCCCAATTGTGCGAGCAGCTGAGTCAACAAATTGCCCCGTGGGGCAGTTACTTAACCTTT
CAGCTCTGGCATCAATAA

Upstream 100 bases:

>100_bases
ATGATTGAGTTCCGTTTTCCGCTAGTGCTACATGCTAGTTTTACGTAAAGTAATGAACAAGAAATTAATTGTGAGCGAAT
ATTGTCGGGCGTAGTGAAAA

Downstream 100 bases:

>100_bases
CCATCAAGCTGCCTCATATTTAACTGCCAGTTTAAAAAGATGATTTTAGCGTTAAGTTAAGAGCCAATTTAATAACCAAT
TTAAGAATCAAATTAAGGTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MSTDRASESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
VKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKASKEHVVGRTTGLGEIDT
MGEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQVADEANLAAEANADDNGLEYGRCFAI
GKMRGTVQIIHEPKLNRFKLAIALTEDSAVDELQLLVTEVRRILDLDADMQQIEQGLSTLPSLGLMPFSGLRIPGAGSLF
EAVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEAS
VDDWLSVKGIGPWTIAYAKLRGLGDPNVFLHLDLIVKKHLLALYIKNNRLDETAAAAVIYSQLCEQLSQQIAPWGSYLTF
QLWHQ

Sequences:

>Translated_565_residues
MSTDRASESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
VKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKASKEHVVGRTTGLGEIDT
MGEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQVADEANLAAEANADDNGLEYGRCFAI
GKMRGTVQIIHEPKLNRFKLAIALTEDSAVDELQLLVTEVRRILDLDADMQQIEQGLSTLPSLGLMPFSGLRIPGAGSLF
EAVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEAS
VDDWLSVKGIGPWTIAYAKLRGLGDPNVFLHLDLIVKKHLLALYIKNNRLDETAAAAVIYSQLCEQLSQQIAPWGSYLTF
QLWHQ
>Mature_564_residues
STDRASESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSAV
KAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGTS
PKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKASKEHVVGRTTGLGEIDTM
GEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQVADEANLAAEANADDNGLEYGRCFAIG
KMRGTVQIIHEPKLNRFKLAIALTEDSAVDELQLLVTEVRRILDLDADMQQIEQGLSTLPSLGLMPFSGLRIPGAGSLFE
AVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEASV
DDWLSVKGIGPWTIAYAKLRGLGDPNVFLHLDLIVKKHLLALYIKNNRLDETAAAAVIYSQLCEQLSQQIAPWGSYLTFQ
LWHQ

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=324, Percent_Identity=29.0123456790123, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788542, Length=178, Percent_Identity=30.8988764044944, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 62159; Mature: 62028

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
STDRASESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYC
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHH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HHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]