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The map label for this gene is trpE [H]

Identifier: 126174909

GI number: 126174909

Start: 3167460

End: 3169154

Strand: Direct

Name: trpE [H]

Synonym: Sbal_2701

Alternate gene names: 126174909

Gene position: 3167460-3169154 (Clockwise)

Preceding gene: 126174902

Following gene: 126174910

Centisome position: 61.78

GC content: 49.79

Gene sequence:

>1695_bases
ATGCCCAAACAGACATTCGCACGCTCAAGCACACTCAAGGCGGCATTAACCTACCACAGCGATCCACTGCGCTTGTATCA
GCACATTACCCAAGATGCGCCCCATACTATGTTGCTGGAATCGGCCGAAATCGACAGTAAAGATCACTTAAAAAGCATGG
TGATGACCCATGCCGCCATGATGATCCGCTGCGACGGTTATCAACTGACCTTTACCGCACTGACCGACAATGGCGCGAGC
TTACTTACCCCAATCGAAACCTTCTTCAGCGAGAGCGGCGATCGTGCTGATATGAGTGCCAATCTAGTCCGTGATAACTT
GACCTTAGTGGTGACGCTGCAAAAAGACACTCAGCTGCAGGATGAAGATGCACGCTTAAAATCAACTTCACCACTCGATG
GCCTGCGGATGTTTATCCAGCAAATTGATTGTGGCACTCATAATGACAGCCAAAGTAAACCCGCCTTTGAGGATCTGTTT
TTAGGTGGCGTGTTGGCCTACGACTTGATTGATACCGTCGAACCGCTGCCAGCCGTACCGAACAGCGATAACGATTGCCC
AGACTACTTATTTTACCTCGCAGAAACCTTAATCCTTATCGACCATAAACTGAAACAAGCCGACATCATTACCCATAATT
TCAGTCGTGATTCAGCCCAGTATGCCGCCATCACCGCAGCGCTGAGCGAGCGAGTTCAGCAGTTAAGCACACAATGTAAA
ACCCTCGGTAATTCACCTGCCGATGTGCCGACACTGGTCGCCATCGACGCAACTGAGCAAGTCAATATTTCCGATGAGGT
GTTTAAACAAACCGTTATCGATTTGAAAGAACACATTATTGCGGGCGATATTTTCCAAGTGGTGCCATCGCGTAGTTTTA
GTTTGCCTTGCCCAAATACCTTAGGGGCTTATCGCGCCCTGCGCCTGACTAACCCAAGCCCTTACATGTTTTATTTCAGA
GGCCAAGATTTCACGCTTTTTGGTGCTTCACCAGAAAGTGCGCTTAAGTACGAGGCCAGCAGTAATCAAGTCGAAGTCTA
CCCGATCGCCGGCACCCGCAAACGCGGAAAAACCGCCACGGGCGAGATTGATTTTGACTTAGACAGCCGCATTGAACTTG
AACTGCGTTTAGATAAAAAAGAACTGTCAGAACACTTAATGTTGGTCGATTTAGCTCGCAACGATATCGCACGCATCAGC
CAAAGCGGCAGCCGTAAAGTCGCTGAATTATTGAAAGTGGACCGTTATTCCCACGTGATGCACCTCGTCAGTCGCGTAAC
GGGTCAATTGCGCCAAGATTTAGATGCGCTGCATGCTTATCAGGCGTGTATGAATATGGGCACTTTAGTCGGCGCGCCAA
AAGTAAGCGCATCACAACTGGTTCGCCAAGCGGAAAAAGCCCGCCGCGGCAGCTACGGCGGCGCTGTCGGTTACCTTAAT
GCCCTTGGTGATATGGACACCTGTATTGTGATCCGCTCGGCCTTTGTCAAAAATGGCACCGCCTTTATTCAAGCGGGCGC
GGGCGTCGTGTTTGATTCGGATCCCCAAAGCGAGGCTGACGAAACCCGTCAAAAAGCTCAAGCAGTGATTTCGGCCATCA
AAATGGGTGCAGGACTGCGAGTCAATGAATCGCCAGCGAATGACGCGTCAGCTCAATCGACTTTTGTACAATCCACTTCA
GTACCATCTAAATAG

Upstream 100 bases:

>100_bases
GTTAGGTGCGAAAAATGTCGGCAGACTCGGGTAACAAGATTAAGAAAGCGAGATAACTCATGATGTTAAAGACATTTTAT
AAGGTAGCTGGAGTATGAAC

Downstream 100 bases:

>100_bases
GAGCCAAACATGAAACTCTATCTACTCGATAACTTTGACTCCTTTACCTACAACTTAGTGGATCAATTTCGCAGCCTAGG
CTGTGAAGTGGTGATTTACC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAMMIRCDGYQLTFTALTDNGAS
LLTPIETFFSESGDRADMSANLVRDNLTLVVTLQKDTQLQDEDARLKSTSPLDGLRMFIQQIDCGTHNDSQSKPAFEDLF
LGGVLAYDLIDTVEPLPAVPNSDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQYAAITAALSERVQQLSTQCK
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFR
GQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARIS
QSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLRVNESPANDASAQSTFVQSTS
VPSK

Sequences:

>Translated_564_residues
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAMMIRCDGYQLTFTALTDNGAS
LLTPIETFFSESGDRADMSANLVRDNLTLVVTLQKDTQLQDEDARLKSTSPLDGLRMFIQQIDCGTHNDSQSKPAFEDLF
LGGVLAYDLIDTVEPLPAVPNSDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQYAAITAALSERVQQLSTQCK
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFR
GQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARIS
QSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLRVNESPANDASAQSTFVQSTS
VPSK
>Mature_563_residues
PKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAMMIRCDGYQLTFTALTDNGASL
LTPIETFFSESGDRADMSANLVRDNLTLVVTLQKDTQLQDEDARLKSTSPLDGLRMFIQQIDCGTHNDSQSKPAFEDLFL
GGVLAYDLIDTVEPLPAVPNSDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQYAAITAALSERVQQLSTQCKT
LGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRG
QDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQ
SGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLNA
LGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLRVNESPANDASAQSTFVQSTSV
PSK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=516, Percent_Identity=53.4883720930233, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788114, Length=440, Percent_Identity=29.7727272727273, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI87082077, Length=305, Percent_Identity=26.5573770491803, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=27.6315789473684, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=419, Percent_Identity=36.7541766109785, Blast_Score=230, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6324361, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 61851; Mature: 61719

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAM
CCCHHHHHHHHHHHHEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
MIRCDGYQLTFTALTDNGASLLTPIETFFSESGDRADMSANLVRDNLTLVVTLQKDTQLQ
EEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHEECCEEEEEEECCCCCCC
DEDARLKSTSPLDGLRMFIQQIDCGTHNDSQSKPAFEDLFLGGVLAYDLIDTVEPLPAVP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
NSDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQYAAITAALSERVQQLSTQCK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNT
HCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
LGAYRALRLTNPSPYMFYFRGQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTAT
HHHHEEEEECCCCCEEEEEECCEEEEECCCCHHHEEEECCCCEEEEEECCCCCCCCCCCC
GEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLKVDRYSHVM
CEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLR
HHCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VNESPANDASAQSTFVQSTSVPSK
ECCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAM
CCHHHHHHHHHHHHEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
MIRCDGYQLTFTALTDNGASLLTPIETFFSESGDRADMSANLVRDNLTLVVTLQKDTQLQ
EEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHEECCEEEEEEECCCCCCC
DEDARLKSTSPLDGLRMFIQQIDCGTHNDSQSKPAFEDLFLGGVLAYDLIDTVEPLPAVP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
NSDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQYAAITAALSERVQQLSTQCK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNT
HCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
LGAYRALRLTNPSPYMFYFRGQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTAT
HHHHEEEEECCCCCEEEEEECCEEEEECCCCHHHEEEECCCCEEEEEECCCCCCCCCCCC
GEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLKVDRYSHVM
CEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLR
HHCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VNESPANDASAQSTFVQSTSVPSK
ECCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1773058; 12620739 [H]