Click here to switch to the map view.

The map label for this gene is phoQ [H]

Identifier: 126174715

GI number: 126174715

Start: 2925124

End: 2926473

Strand: Direct

Name: phoQ [H]

Synonym: Sbal_2502

Alternate gene names: 126174715

Gene position: 2925124-2926473 (Clockwise)

Preceding gene: 126174714

Following gene: 126174717

Centisome position: 57.05

GC content: 45.93

Gene sequence:

>1350_bases
ATGCAACTAAGATTAAAATTTAAGAAACGTCTGCTGACGCGGATGTTTCTCACCTCGCTATCGATTATTGCCTTAGTGGG
TTTTGGTCTCGCATGGATGGTTAATATTCTGCATGCGCAAAATAGCTATAACGAAGAAACTGCACAACTCATTTCTGAAA
TCCCCCAAGTCGCCGCCGAATTGCGGGAGCACGATCTCATCCCCGATACCAGTGCGTGGCTGGAGGAAAATAATAAGCAA
GAACGTTATGTGATTGCGAGTTGCGATGAAAAATTTAAACAAGTTTGGACTTCATCCCTCGCAGTAGACCGTGGCTTATT
TGATACTTGCGAGCGTTTTAACGAAATTCGCAACGATTCTCCGCCCTATTATCTTACTATGGCCGATGACAGAGGTTACT
TCGTCTATTTGCTCGCGGTGGAAATTGCTAGCATACATTACAATTTGCTCGTCCTCAAAGATGCCGCTAAACTCGAGCAG
GAATACAGTAAGTTCAGTAAACGCACTTATATTCGACTCGCCATGGTATTAGCCTTAGCGCTAATTCTATTGGTCAGCGC
CGCCTATTGGGGAATGCGACCCTTAGTACGGATGCAGAATGAACTGCAATCGATTAACCAAGGTAAGAGTAAATCACTTT
CAGAAGGCTATCCTGTTGAACTCGAAGGGGTAACCCAAGCACTCAACCAAATGCTGCAACAATCGAGCGCCCAACAACAG
CGCTATCAAAATGCCATGAACGACTTAGCACACAGTCTCAAGACCCGCTTAGCGGCTGTGCATGCCATCACAGATGACGC
CAGTTTGAGTAAACAATCGGCGAGCGAAAAGATCATGGAACAGGTCAGTCAGATGGATCAGCTGGTCAAATATCAATTAA
AACGCGCCATGTTAGGCCGCCAAGGCCTGAAGCAAGAACAGACTGTGATTGCGCCCTTAGTCGATCAATTAGCGCAAATG
TTATTTAAAATTTATCGCGATAAGCAAGTACAGTTCTCGGCGAGCATTCCTCCCTCCTTAATGTTTCCCGGCAACAAGGG
CGACTTGATGGAGCTGTGTGGCAACCTGATGGAAAACGCTTTCCGCTTATGTATCAGCCAAGTGCATGTATCAGCTAAGA
TTAGTTCACAAGGTGAGTTTGAACTTATTGTCGAGGATGATGGCCCAGGTGTCGAAGAAAGCCTAAGACAAAAGATTATC
CAACGCGGCGTGCGGGCCGATACCCAGTCACCAGGACAAGGTATCGGATTAGCCGTATGTGATGAAATCGTTCACAGCTA
CGGTGGTAGTTTAAAAATTGAGGAAAGCCGCTTAGAAGGTGCACTCTTTAGGATCCGTATCCCTGTTTAA

Upstream 100 bases:

>100_bases
TTGAAGTCATGGTCAGCCGCCTGCGCAAAAAACTGACCCGCGATGGGATAGACAATCCTATCGTCACCATTCGCGGCCAA
GGATATAAATTTAACCTGCC

Downstream 100 bases:

>100_bases
GGACAGGGATAGCTCACAACAAAGATAGCTAAATACAAAGATAAAAAAATACTAAAAGTTAAAACAAGGATGTGTAACTT
TGTGGATACTGAACTTTATC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQLRLKFKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAQLISEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVIASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIASIHYNLLVLKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKSKSLSEGYPVELEGVTQALNQMLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDASLSKQSASEKIMEQVSQMDQLVKYQLKRAMLGRQGLKQEQTVIAPLVDQLAQM
LFKIYRDKQVQFSASIPPSLMFPGNKGDLMELCGNLMENAFRLCISQVHVSAKISSQGEFELIVEDDGPGVEESLRQKII
QRGVRADTQSPGQGIGLAVCDEIVHSYGGSLKIEESRLEGALFRIRIPV

Sequences:

>Translated_449_residues
MQLRLKFKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAQLISEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVIASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIASIHYNLLVLKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKSKSLSEGYPVELEGVTQALNQMLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDASLSKQSASEKIMEQVSQMDQLVKYQLKRAMLGRQGLKQEQTVIAPLVDQLAQM
LFKIYRDKQVQFSASIPPSLMFPGNKGDLMELCGNLMENAFRLCISQVHVSAKISSQGEFELIVEDDGPGVEESLRQKII
QRGVRADTQSPGQGIGLAVCDEIVHSYGGSLKIEESRLEGALFRIRIPV
>Mature_449_residues
MQLRLKFKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAQLISEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVIASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIASIHYNLLVLKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKSKSLSEGYPVELEGVTQALNQMLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDASLSKQSASEKIMEQVSQMDQLVKYQLKRAMLGRQGLKQEQTVIAPLVDQLAQM
LFKIYRDKQVQFSASIPPSLMFPGNKGDLMELCGNLMENAFRLCISQVHVSAKISSQGEFELIVEDDGPGVEESLRQKII
QRGVRADTQSPGQGIGLAVCDEIVHSYGGSLKIEESRLEGALFRIRIPV

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=290, Percent_Identity=35.5172413793103, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790551, Length=266, Percent_Identity=27.4436090225564, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787894, Length=294, Percent_Identity=27.5510204081633, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=25.6198347107438, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=27.9835390946502, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=25, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786837, Length=145, Percent_Identity=34.4827586206897, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=23.8434163701068, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50721; Mature: 50721

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLKFKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAQLISEIPQVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSAWLEENNKQERYVIASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDS
HHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PPYYLTMADDRGYFVYLLAVEIASIHYNLLVLKDAAKLEQEYSKFSKRTYIRLAMVLALA
CCEEEEEECCCCCEEEHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLVSAAYWGMRPLVRMQNELQSINQGKSKSLSEGYPVELEGVTQALNQMLQQSSAQQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RYQNAMNDLAHSLKTRLAAVHAITDDASLSKQSASEKIMEQVSQMDQLVKYQLKRAMLGR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLKQEQTVIAPLVDQLAQMLFKIYRDKQVQFSASIPPSLMFPGNKGDLMELCGNLMENA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHH
FRLCISQVHVSAKISSQGEFELIVEDDGPGVEESLRQKIIQRGVRADTQSPGQGIGLAVC
HHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DEIVHSYGGSLKIEESRLEGALFRIRIPV
HHHHHHCCCCEEEEHHHHCCEEEEEEECC
>Mature Secondary Structure
MQLRLKFKKRLLTRMFLTSLSIIALVGFGLAWMVNILHAQNSYNEETAQLISEIPQVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSAWLEENNKQERYVIASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDS
HHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PPYYLTMADDRGYFVYLLAVEIASIHYNLLVLKDAAKLEQEYSKFSKRTYIRLAMVLALA
CCEEEEEECCCCCEEEHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLVSAAYWGMRPLVRMQNELQSINQGKSKSLSEGYPVELEGVTQALNQMLQQSSAQQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RYQNAMNDLAHSLKTRLAAVHAITDDASLSKQSASEKIMEQVSQMDQLVKYQLKRAMLGR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLKQEQTVIAPLVDQLAQMLFKIYRDKQVQFSASIPPSLMFPGNKGDLMELCGNLMENA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHH
FRLCISQVHVSAKISSQGEFELIVEDDGPGVEESLRQKIIQRGVRADTQSPGQGIGLAVC
HHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DEIVHSYGGSLKIEESRLEGALFRIRIPV
HHHHHHCCCCEEEEHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA