Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 126174685

GI number: 126174685

Start: 2884158

End: 2886425

Strand: Reverse

Name: clpA [H]

Synonym: Sbal_2472

Alternate gene names: 126174685

Gene position: 2886425-2884158 (Counterclockwise)

Preceding gene: 126174686

Following gene: 126174681

Centisome position: 56.29

GC content: 48.37

Gene sequence:

>2268_bases
ATGCTGAACAAAGATCTGGAAGTCACCTTAAATCTGGCGTTTCAGCAAGCCAGAGACGCGCGTCACGAGTATATGACAGT
GGAACATCTGTTATTAGCTCTGATCGACAATCCTGCGGCTCAAGAAGCGTTAATCGCCTGTGGAGCGAATCTAGATAAAC
TCAGAGATGAAGTGGCAAGCTTTATCCAACAAACAACCCCAATCATTGCCGATATTGATGATGACAAAGAAACTCAGCCG
ACGCTGGGGTTCCAACGAGTGCTGCAACGTGCAGTATTCCATGTGCAGTCATCGGGTCGCAATGAAGTGAACGGCGCTAA
CGTGTTAGTCGCCATTTTCAGTGAGCAAGAATCCCAAGCCGTGTATTTACTGCGCCGCTGCGATATTAGTCGCCTAGACG
TTGTGAATTTTATTTCCCATGGTTTCGCCAAAAATGATGATGCTGAGTCACATCAAGATCAAGAACGGGTTGAAGATCAG
GGCGAAAGCAGCGAAGAGCGCAGCATGTTGTCGCAATTTGCGTCCAACTTAAACCAACTTGCTAAGCAAGGGATCATCGA
CCCACTGATTGGTCGCGATCAAGAAATTGAGCGCGCGATTCAAACCCTGTGCCGTCGCCGTAAAAATAATCCACTGTTAG
TGGGTGAGGCGGGCGTAGGTAAAACAGCTATTGCCGAAGGGCTGGCGTATCGCATCGTCAATAAACAAGTGCCCGATGTG
ATGCTTGAAGCCACAGTGTATTCCTTGGATTTAGGTTCACTGCTGGCGGGAACTAAGTATCGCGGCGACTTTGAAAAGCG
CTTTAAGAACCTGTTAAAAGAACTGGCGGCTGATAAGCATGCCATCCTATTCATCGATGAGATCCACACCATCATCGGTG
CGGGCGCGGCCTCTGGCGGCGTAATGGATGCCTCTAATCTGCTGAAACCTTTACTATCTAGCGGTAACTTGCGCTGCATG
GGCTCGACAACTTTCCAAGAATATCAAAGTATTTTTGAGAAAGACCGCGCACTTGCACGTCGTTTCCAAAAGGTGGATAT
CAATGAGCCTTCAGTGGAAGAAACCACTAAGATTTTGATGGGGCTTAAGTCTAAATACGAAGAATATCATGGGGTTCGTT
ATACACAGGCTGCGATCAGCAGCGCTGCAGTATTATCGGCCAAGCACATCAACGACAGACATTTACCCGATAAAGCCATC
GATGTGATCGATGAAGCGGGTGCACGTATGGTGATGTTGCCTATGAGCAAACGTAAAAAGACCATAGGCCAAGCCGAGAT
TGAGTCGATAGTGGCGAAAATGGCGCGTATCCCTGAGAAGTCGGTATCCGCCACTGATAAGGACTTACTGCGTAATCTTG
AGCGTAACCTTAAGATGGTGGTCTTTGGCCAAGACAAGGCCATTGAGAGTCTGAGTTCGGCCATTCGCTTATCGCGCAGT
GGCTTAGGCACAGACAGGAAACCTGTGGGCAGCTTCTTATTCGCTGGTACCACCGGTGTGGGTAAAACCGAAGTCACTAA
CCAACTGGCCAACTGTTTGGGGATGAAACTGGTGCGCTTTGACATGTCTGAGTACATGGAAAGCCACACTGTGTCACGCT
TGATTGGTGCGCCTCCTGGATATGTGGGTTATGACCAAGGTGGCTTGCTCACCGATGCTGTGATTAAAAATCCGCACTGC
GTGGTGCTATTGGATGAAATCGAGAAGGCCCACCGCGATGTCTATAACTTGCTGTTGCAGGTGATGGATCACGGTACTTT
GACCGATAATAATGGTCGTAAGGCTGACTTCAGACACGTGACTTTGGTGATGACGACGAACGCGGGTGTTCAGGAGACTA
TTCGTAAGTCGATTGGCTTTACCCAACAAGATCACACTCAAGATGCGTTATCTGAAATTAATCGGGTATTTTCGCCAGAA
TTTCGAAATCGTCTCGATTCCATCATTTGGTTCAACCATTTGGATATGACTATTATCGCCAAAGTGGTCGATAAATTCTT
GGTGGAGTTGCAGGCTCAATTGGATGCAAAACACGTTACTTTGGAAGTCAGCGACGAAGCCAGAACCTTGTTGGCCGAGA
AAGGCTACGACAAGAACATGGGCGCGCGTCCAATGGCTCGGGTCGTGACCGAATTGATCAAACGTCCATTGGCAGACGAG
ATCTTATTTGGTGTCTTAGAGTCAGGCGGTGTGGCGCATGTGGATGTGAAGGAGGGCGAGCTTGTCATTCGTACCGAACG
TCACGAAAAAGCGACAACAAAAGCTTAA

Upstream 100 bases:

>100_bases
AATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCGTTAGAGAAAGCATAAAACCGCTTTACTCTGTAGTCTGT
TGTTAATTTTGGGGGTGCTT

Downstream 100 bases:

>100_bases
CGCTTGATTATCCATTAGTTTTAGACATAAAAATGGCTGCAATTGCAGCCATTTTTTTCATCTTTCGCAAACAAAAAAAC
CCGGCCTTGCCGGGTTTTTA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGTTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA

Sequences:

>Translated_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGTTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
>Mature_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGTTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=31.5436241610738, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1787109, Length=732, Percent_Identity=69.9453551912568, Blast_Score=1068, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=408, Percent_Identity=42.4019607843137, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=320, Percent_Identity=49.375, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=408, Percent_Identity=38.2352941176471, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83831; Mature: 83831

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQGESSEERSMLSQFASNLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDRKPVGSFLFAGTTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQGESSEERSMLSQFASNLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDRKPVGSFLFAGTTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]