Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 126174641

GI number: 126174641

Start: 2829797

End: 2830888

Strand: Direct

Name: hisB [H]

Synonym: Sbal_2428

Alternate gene names: 126174641

Gene position: 2829797-2830888 (Clockwise)

Preceding gene: 126174640

Following gene: 126174642

Centisome position: 55.19

GC content: 50.92

Gene sequence:

>1092_bases
ATGAACCCACAATTTATCCCGAACGTTGCACAAAAAATTCTGTTTATCGACCGCGATGGCACCTTGATTGAAGAGCCCGT
CACCGACAAACAGGTCGATAGTCTGGCTAAATTAGTGTTTGAGCCACAGGTGATCCCCGCTTTGCTACGTCTGCAAAAGG
CGGGATTTCGTTTAGTCATGGTCAGCAATCAAGACGGCCTTGGCACACCGTCTTTCCCGCAGGAAGATTTCGACGCGCCC
CACAATATGATGATGCAAATCCTCAAAAGCCAAGGGGTTAACTTCGAAGATGTGGTGATTTGCCCGCACTTTAATGATGA
AAATTGCAGTTGCCGTAAACCTAAGCTTGGGCTAGTAAAAGACTATCTCACCCAAGGCTGCATCGATTTCACTCAATCGG
CGGTGATTGGCGATCGCGAAACCGATGTGGAACTGGGCAATGCCATGGGCATTAAAAGCCTGAAATATCAACGCGACACT
TTGGGCTGGAACGCCATAGTCGATGCGCTGCTCAATAAAGGCCGCACCGCAACGGTCGTGCGCACCACCAAAGAAACCGA
TATTCGCGTAACCGTGGATCTCGACAGTTCAATCAAAGGAAAAATCGACACTGGCATTGGCTTTTTCGACCACATGCTCG
ATCAAATTGCCACCCACGGTAATTTTAGAATGGATGTGAAAGTCGATGGCGACTTAGAAATCGACGATCACCACAGCGTC
GAAGACACGGCGCTAGCCATAGGTGATGCCCTGCGCCAAGCGCTCGGTGACAAACGCGGCATTGCCCGTTTCGGCTTTAG
TCTGCCGATGGACGAAGCCAAGGGCGAATGTCTGCTGGATATCTCTGGCCGTCCTTTTATCAAGTTCTCAGCCGATTTTG
AGCGTGAGCACGTAGGCGAAATGGCCACTGAAATGGTGCCACACTTTTTCCGCTCCTTTGCCGATGGCCTGCGCTGTACG
CTGCATGTGTCGACCGAAGGCGATAACGATCACCACAAGGTTGAAGCCCTGTTTAAAGTGCTCGGCCGCGCGCTACGCCA
AGCGGTTAAAGTCGAAGGCGATATTCTGCCATCGAGTAAAGGCGTACTTTAA

Upstream 100 bases:

>100_bases
TGAACATAAAAACTAATAAAACCAATAAAAAGCGAATGCCGCGTTGAAGGTAAAATCAGCTTAAGCATTAGCTAAACGAA
TTGAATTTGAAGGTAGAGCC

Downstream 100 bases:

>100_bases
GGCATCAGCATAAATCGTTTAAGAGGTTAGGATGCAACAAGACACTCAACAATCTAAACTAGCTCAGTTAAGCGCTAATG
AGCCACAAGATACTGCACTG

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNPQFIPNVAQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILKSQGVNFEDVVICPHFNDENCSCRKPKLGLVKDYLTQGCIDFTQSAVIGDRETDVELGNAMGIKSLKYQRDT
LGWNAIVDALLNKGRTATVVRTTKETDIRVTVDLDSSIKGKIDTGIGFFDHMLDQIATHGNFRMDVKVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDISGRPFIKFSADFEREHVGEMATEMVPHFFRSFADGLRCT
LHVSTEGDNDHHKVEALFKVLGRALRQAVKVEGDILPSSKGVL

Sequences:

>Translated_363_residues
MNPQFIPNVAQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILKSQGVNFEDVVICPHFNDENCSCRKPKLGLVKDYLTQGCIDFTQSAVIGDRETDVELGNAMGIKSLKYQRDT
LGWNAIVDALLNKGRTATVVRTTKETDIRVTVDLDSSIKGKIDTGIGFFDHMLDQIATHGNFRMDVKVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDISGRPFIKFSADFEREHVGEMATEMVPHFFRSFADGLRCT
LHVSTEGDNDHHKVEALFKVLGRALRQAVKVEGDILPSSKGVL
>Mature_363_residues
MNPQFIPNVAQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVMVSNQDGLGTPSFPQEDFDAP
HNMMMQILKSQGVNFEDVVICPHFNDENCSCRKPKLGLVKDYLTQGCIDFTQSAVIGDRETDVELGNAMGIKSLKYQRDT
LGWNAIVDALLNKGRTATVVRTTKETDIRVTVDLDSSIKGKIDTGIGFFDHMLDQIATHGNFRMDVKVDGDLEIDDHHSV
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDISGRPFIKFSADFEREHVGEMATEMVPHFFRSFADGLRCT
LHVSTEGDNDHHKVEALFKVLGRALRQAVKVEGDILPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=61.9718309859155, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786399, Length=148, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=46.0606060606061, Blast_Score=156, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40258; Mature: 40258

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQFIPNVAQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVM
CCCCCCHHHHHHEEEECCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEE
VSNQDGLGTPSFPQEDFDAPHNMMMQILKSQGVNFEDVVICPHFNDENCSCRKPKLGLVK
EECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHH
DYLTQGCIDFTQSAVIGDRETDVELGNAMGIKSLKYQRDTLGWNAIVDALLNKGRTATVV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEE
RTTKETDIRVTVDLDSSIKGKIDTGIGFFDHMLDQIATHGNFRMDVKVDGDLEIDDHHSV
EECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCC
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDISGRPFIKFSADFEREHVGE
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHH
MATEMVPHFFRSFADGLRCTLHVSTEGDNDHHKVEALFKVLGRALRQAVKVEGDILPSSK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVL
CCC
>Mature Secondary Structure
MNPQFIPNVAQKILFIDRDGTLIEEPVTDKQVDSLAKLVFEPQVIPALLRLQKAGFRLVM
CCCCCCHHHHHHEEEECCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEE
VSNQDGLGTPSFPQEDFDAPHNMMMQILKSQGVNFEDVVICPHFNDENCSCRKPKLGLVK
EECCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHH
DYLTQGCIDFTQSAVIGDRETDVELGNAMGIKSLKYQRDTLGWNAIVDALLNKGRTATVV
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEE
RTTKETDIRVTVDLDSSIKGKIDTGIGFFDHMLDQIATHGNFRMDVKVDGDLEIDDHHSV
EECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCC
EDTALAIGDALRQALGDKRGIARFGFSLPMDEAKGECLLDISGRPFIKFSADFEREHVGE
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHH
MATEMVPHFFRSFADGLRCTLHVSTEGDNDHHKVEALFKVLGRALRQAVKVEGDILPSSK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GVL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]