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The map label for this gene is hisC [H]

Identifier: 126174640

GI number: 126174640

Start: 2828496

End: 2829695

Strand: Direct

Name: hisC [H]

Synonym: Sbal_2427

Alternate gene names: 126174640

Gene position: 2828496-2829695 (Clockwise)

Preceding gene: 126174639

Following gene: 126174641

Centisome position: 55.16

GC content: 51.67

Gene sequence:

>1200_bases
ATGAGCCAAGTGAGCAGCATGGAAAAGACAGCAGAACCCGCAGCATTAGCATCGACGTTAGCACCATCAACGTTAACGCA
ATCGGCGTCGCTAAATTTAGCCGAGCGCCTAGCGCGCCCTGAATTACTGGATTTAACGCCCTACCAAAGTGCCCGCAGAC
TGGGCGGTCGTGGTGATATTTGGATCAATGCCAACGAATCGCCCTTTAATAATGTCGATACGGCAGCGCTCGATTTATCG
AAATTGAATCGTTACCCAGAATGCCAACCGCCGCAGCTTATCAAGGCCTACAGCGAGTACAGCGGCGTAAGCGCCAGCAA
GATAGTCGCCAGCCGCGGCGCCGATGAAGCGATTGAACTGTTAATTCGCGCTTTTTGTATACCTGGCGTCGACAGCATTG
CTTGCTTTGGCCCGACGTACGGCATGTATGCCATCAGCGCGAACACCTTTAATGTGGGCGTTAAAGCGTTAAATCTCAGC
GCGGAATATGGCTTGCCGACCAGCTATGCTGAAGACGTTTGCGGCGCAAAACTGGTGTTTATCTGCAATCCCAATAATCC
GACGGGGACTATGATCGACAAAGCCATTATCGAGCAAGCGATCAAAGCCCTGCCCGATGCGCTTGTGGTGATCGATGAGG
CCTATATTGAGTTTTGCCCTGAATACAGTGTGGCGGATTTACTGAAAAGCTATCCGAATCTAGTGGTACTGCGCACCCTA
TCAAAAGCCTTTGCACTCGCCGGAGCACGCTGCGGTTTTATGCTGGCAAATGAGGCCGTAGTCGACATCATTATGCGCGT
AATTGCGCCCTATCCTGTGCCGCTACCCGTGAGTGAAGTCGCCACCCAAGCGCTATCAAGCGCTGGCGTTGCGCGGATGA
AAGTGCAAGTTGCACAATTAAATGAGCAAGGCGCCAGACTCACCGCAGCGATCAGCGCATATTGTTCAAAATCGAATAGC
TCAGATTCTCGCGCCCGCGTGCTTAAGCCTAACGGCAATTATGTGCTGGCTGAATTTGATGATGTCGCCAAGGTCGCGGC
GTTACTGCAAGGCAGCGGTGTTGTCGCCCGCGCCTACAAAGACCCAAGGCTTGCTAAGGCCATCCGTTTTAGCTTTAGTT
CAAAGGCGGATACCGATGTGTTAGTGAATTTATTTGAATCGCAGCGCACTGAGCAGTCACCAGAAACGAATAATAAGTAA

Upstream 100 bases:

>100_bases
TGCTCGATGCACACAAAAATGCCGTTGCCATTCGCCTAGCTAGCCTAGAGAAATGATCCGCTTAATCTTAAGTAATTGAA
AATAGAGCTGAGTGAAGAAA

Downstream 100 bases:

>100_bases
CTGAACATAAAAACTAATAAAACCAATAAAAAGCGAATGCCGCGTTGAAGGTAAAATCAGCTTAAGCATTAGCTAAACGA
ATTGAATTTGAAGGTAGAGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSQVSSMEKTAEPAALASTLAPSTLTQSASLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLS
KLNRYPECQPPQLIKAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLS
AEYGLPTSYAEDVCGAKLVFICNPNNPTGTMIDKAIIEQAIKALPDALVVIDEAYIEFCPEYSVADLLKSYPNLVVLRTL
SKAFALAGARCGFMLANEAVVDIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNS
SDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK

Sequences:

>Translated_399_residues
MSQVSSMEKTAEPAALASTLAPSTLTQSASLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLS
KLNRYPECQPPQLIKAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLS
AEYGLPTSYAEDVCGAKLVFICNPNNPTGTMIDKAIIEQAIKALPDALVVIDEAYIEFCPEYSVADLLKSYPNLVVLRTL
SKAFALAGARCGFMLANEAVVDIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNS
SDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK
>Mature_398_residues
SQVSSMEKTAEPAALASTLAPSTLTQSASLNLAERLARPELLDLTPYQSARRLGGRGDIWINANESPFNNVDTAALDLSK
LNRYPECQPPQLIKAYSEYSGVSASKIVASRGADEAIELLIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSA
EYGLPTSYAEDVCGAKLVFICNPNNPTGTMIDKAIIEQAIKALPDALVVIDEAYIEFCPEYSVADLLKSYPNLVVLRTLS
KAFALAGARCGFMLANEAVVDIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQLNEQGARLTAAISAYCSKSNSS
DSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYKDPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=356, Percent_Identity=43.8202247191011, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6322075, Length=301, Percent_Identity=33.5548172757475, Blast_Score=155, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42696; Mature: 42565

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVSSMEKTAEPAALASTLAPSTLTQSASLNLAERLARPELLDLTPYQSARRLGGRGDI
CCCHHHHHHHCCHHHHHHHHCCHHHHHHHCCCHHHHHCCCCEECCCCCHHHHHCCCCCCE
WINANESPFNNVDTAALDLSKLNRYPECQPPQLIKAYSEYSGVSASKIVASRGADEAIEL
EEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
LIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDVCGAKLVF
HHHHHHCCCCCCEEECCCCCCEEEEECCEEEECEEEEEEECCCCCCCHHHHHHCCCEEEE
ICNPNNPTGTMIDKAIIEQAIKALPDALVVIDEAYIEFCPEYSVADLLKSYPNLVVLRTL
EECCCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCHHHHHHHCCCEEEHHHH
SKAFALAGARCGFMLANEAVVDIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
NEQGARLTAAISAYCSKSNSSDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYK
CCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEECCC
DPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK
CHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SQVSSMEKTAEPAALASTLAPSTLTQSASLNLAERLARPELLDLTPYQSARRLGGRGDI
CCHHHHHHHCCHHHHHHHHCCHHHHHHHCCCHHHHHCCCCEECCCCCHHHHHCCCCCCE
WINANESPFNNVDTAALDLSKLNRYPECQPPQLIKAYSEYSGVSASKIVASRGADEAIEL
EEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
LIRAFCIPGVDSIACFGPTYGMYAISANTFNVGVKALNLSAEYGLPTSYAEDVCGAKLVF
HHHHHHCCCCCCEEECCCCCCEEEEECCEEEECEEEEEEECCCCCCCHHHHHHCCCEEEE
ICNPNNPTGTMIDKAIIEQAIKALPDALVVIDEAYIEFCPEYSVADLLKSYPNLVVLRTL
EECCCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHHHHCCCCCHHHHHHHCCCEEEHHHH
SKAFALAGARCGFMLANEAVVDIIMRVIAPYPVPLPVSEVATQALSSAGVARMKVQVAQL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
NEQGARLTAAISAYCSKSNSSDSRARVLKPNGNYVLAEFDDVAKVAALLQGSGVVARAYK
CCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCEEEECCC
DPRLAKAIRFSFSSKADTDVLVNLFESQRTEQSPETNNK
CHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]