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The map label for this gene is hisD [H]

Identifier: 126174639

GI number: 126174639

Start: 2827150

End: 2828451

Strand: Direct

Name: hisD [H]

Synonym: Sbal_2426

Alternate gene names: 126174639

Gene position: 2827150-2828451 (Clockwise)

Preceding gene: 126174638

Following gene: 126174640

Centisome position: 55.14

GC content: 52.76

Gene sequence:

>1302_bases
ATGGAAATCCTAACTTGGTCAACCTTATCAACCGCCGAGCAGAAAACGGCGCTGAAACGCTCGCCCTTAATTGGTGACAG
CGGCTTAGAGCAAAGCGTTCGCGCCATTCTCGATGCGGTGGCGACGCGGGGTGATGCCGCCATTCAAGAATTTAATCAAA
AATTTGATGGTTTCAATAGCGCGAAGATTGGCGAGCTGCGCATGGGCGAAGCCGAAATAGCTGCGGCAAGCGCACGGGTA
TCGCCAGAGCTGAAAGCAGCTATATCCAAAGCCATGGCGAACATAGATGTGTTTCACAGCGCCCAGCAATTTCGCCCGAT
TGATATGGAAACCGAGGCGGGAGTACGCTGCGAGTTACGTAGCGAACCAATTGAAAAAGTCGGTTTATATATCCCCGGTG
GCAGTGCACCATTAATTTCTACCGTGATGATGCTTGCCCTGCCCGCCAAGATCGCCGGCTGCGAACAAAGAGTATTGGTC
AGCCCACCGCCGATCAACGATGCCATTATCTATGCCGCCAATGCCTGTGGGATCACTGAAATCTATCAAGTGGGCGGCGC
GCAGGCCATTGCGGCACTGGCCTTTGGCACGGAAACGATTCCGGCGGTTGATAAGATTTTTGGCCCAGGTAACCGCTATG
TGACTGAAGCTAAACGCTTAGTGTCACAGGATGGTCGCTGCACTGCGTGTATCGATATGCCCGCTGGCCCTTCTGAGGTG
TTAGTGATTGCCGATAGCGACGCAAATTGCGAATTTATCGCCGCCGATTTGCTTTCGCAAGCTGAGCACGGCCCTGATTC
ACAAGTGATTTTAGTGACAGATTCGCAAGCTATCGCGGATGGTGTGAATGATGCGCTGACGAGACAACTCGCCGTCCTGC
CACGTCAAGATATCGCGTCAACGGCGCTACTGAGCAGTCGCACTTTTGTTGTTGACGATATGCTGCAAGCCGCGCAGGTT
TCTAATCAATATGGGCCTGAGCACTTGATCATTCAAACGCGCTTTCCACGTGAGGTATTGAAAAACATTCGCGCAGCTGG
CTCAGTGTTTTTAGGCGCTTATACGCCTGAATCTGTTGGTGATTATGCCAGTGGCACCAACCACGTGCTGCCGACTTACG
GTTACAGCCGCGCCGTGTCGAGCCTGTCATTAGCCGACTTTAGCCGCCGCTTTACCGTGCAGGAACTCAGCGCTAAGGGC
TTAATCGGATTGGGGCAAGCGGTCATGACGTTAGCCAGCAACGAATTGCTCGATGCACACAAAAATGCCGTTGCCATTCG
CCTAGCTAGCCTAGAGAAATGA

Upstream 100 bases:

>100_bases
CAGTACCGAAGATTTGTTTTGGGATACCATGGAACAGCTGACTGCGCTCGGTGCCAGCTCAATTCTGGTGATGCCAATCG
AAAAAATGATGGGGTAATGT

Downstream 100 bases:

>100_bases
TCCGCTTAATCTTAAGTAATTGAAAATAGAGCTGAGTGAAGAAAATGAGCCAAGTGAGCAGCATGGAAAAGACAGCAGAA
CCCGCAGCATTAGCATCGAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MEILTWSTLSTAEQKTALKRSPLIGDSGLEQSVRAILDAVATRGDAAIQEFNQKFDGFNSAKIGELRMGEAEIAAASARV
SPELKAAISKAMANIDVFHSAQQFRPIDMETEAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEQRVLV
SPPPINDAIIYAANACGITEIYQVGGAQAIAALAFGTETIPAVDKIFGPGNRYVTEAKRLVSQDGRCTACIDMPAGPSEV
LVIADSDANCEFIAADLLSQAEHGPDSQVILVTDSQAIADGVNDALTRQLAVLPRQDIASTALLSSRTFVVDDMLQAAQV
SNQYGPEHLIIQTRFPREVLKNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LIGLGQAVMTLASNELLDAHKNAVAIRLASLEK

Sequences:

>Translated_433_residues
MEILTWSTLSTAEQKTALKRSPLIGDSGLEQSVRAILDAVATRGDAAIQEFNQKFDGFNSAKIGELRMGEAEIAAASARV
SPELKAAISKAMANIDVFHSAQQFRPIDMETEAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEQRVLV
SPPPINDAIIYAANACGITEIYQVGGAQAIAALAFGTETIPAVDKIFGPGNRYVTEAKRLVSQDGRCTACIDMPAGPSEV
LVIADSDANCEFIAADLLSQAEHGPDSQVILVTDSQAIADGVNDALTRQLAVLPRQDIASTALLSSRTFVVDDMLQAAQV
SNQYGPEHLIIQTRFPREVLKNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LIGLGQAVMTLASNELLDAHKNAVAIRLASLEK
>Mature_433_residues
MEILTWSTLSTAEQKTALKRSPLIGDSGLEQSVRAILDAVATRGDAAIQEFNQKFDGFNSAKIGELRMGEAEIAAASARV
SPELKAAISKAMANIDVFHSAQQFRPIDMETEAGVRCELRSEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEQRVLV
SPPPINDAIIYAANACGITEIYQVGGAQAIAALAFGTETIPAVDKIFGPGNRYVTEAKRLVSQDGRCTACIDMPAGPSEV
LVIADSDANCEFIAADLLSQAEHGPDSQVILVTDSQAIADGVNDALTRQLAVLPRQDIASTALLSSRTFVVDDMLQAAQV
SNQYGPEHLIIQTRFPREVLKNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKG
LIGLGQAVMTLASNELLDAHKNAVAIRLASLEK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=433, Percent_Identity=57.2748267898383, Blast_Score=495, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=45.9523809523809, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45935; Mature: 45935

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILTWSTLSTAEQKTALKRSPLIGDSGLEQSVRAILDAVATRGDAAIQEFNQKFDGFNS
CCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
AKIGELRMGEAEIAAASARVSPELKAAISKAMANIDVFHSAQQFRPIDMETEAGVRCELR
CCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEQRVLVSPPPINDAIIYAANACGITE
CCCHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCCHHH
IYQVGGAQAIAALAFGTETIPAVDKIFGPGNRYVTEAKRLVSQDGRCTACIDMPAGPSEV
HHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCE
LVIADSDANCEFIAADLLSQAEHGPDSQVILVTDSQAIADGVNDALTRQLAVLPRQDIAS
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHH
TALLSSRTFVVDDMLQAAQVSNQYGPEHLIIQTRFPREVLKNIRAAGSVFLGAYTPESVG
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCHHHC
DYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKGLIGLGQAVMTLASNELLDAH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
KNAVAIRLASLEK
CCEEEEEEECCCC
>Mature Secondary Structure
MEILTWSTLSTAEQKTALKRSPLIGDSGLEQSVRAILDAVATRGDAAIQEFNQKFDGFNS
CCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
AKIGELRMGEAEIAAASARVSPELKAAISKAMANIDVFHSAQQFRPIDMETEAGVRCELR
CCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
SEPIEKVGLYIPGGSAPLISTVMMLALPAKIAGCEQRVLVSPPPINDAIIYAANACGITE
CCCHHHCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEECCCCHHH
IYQVGGAQAIAALAFGTETIPAVDKIFGPGNRYVTEAKRLVSQDGRCTACIDMPAGPSEV
HHHCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCE
LVIADSDANCEFIAADLLSQAEHGPDSQVILVTDSQAIADGVNDALTRQLAVLPRQDIAS
EEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHH
TALLSSRTFVVDDMLQAAQVSNQYGPEHLIIQTRFPREVLKNIRAAGSVFLGAYTPESVG
HHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCHHHC
DYASGTNHVLPTYGYSRAVSSLSLADFSRRFTVQELSAKGLIGLGQAVMTLASNELLDAH
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
KNAVAIRLASLEK
CCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]