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The map label for this gene is gap [H]

Identifier: 126174432

GI number: 126174432

Start: 2562916

End: 2564349

Strand: Reverse

Name: gap [H]

Synonym: Sbal_2216

Alternate gene names: 126174432

Gene position: 2564349-2562916 (Counterclockwise)

Preceding gene: 126174435

Following gene: 126174431

Centisome position: 50.01

GC content: 46.86

Gene sequence:

>1434_bases
ATGAGCGCTGATAAACACCTACAAAGTTGGCAAGAACGTTTTGAAATGGCAGAGGCAATGCAGCCTTTGTTAGGCAAGTT
GTACCGTAACCAAGGCGTTGAAGTCGTGGTCTACGGCAAGCCGTTACTCAATGCTTCTACGATTGAAATCATTAAAGCGC
ACCGTTTAGTTCGTCGTCATGTCGGTGAAAAATTACGTTTACGCGAGAGTTTCCCCTTCGTTCAAGCTTTGAGCAAACTC
GCAGTTAAACAATGTAAAGTGGATATTGGTAAGCTTGCAGTCAATTACTGGCGCGATCACACCGATGTCAGCGAAATTGA
AAACTATATGGCAAAAGAGTTGGCCGATGCCATCGACCATGCTGATGATGTCGCGCCGCGTGATGTCGTGCTTTATGGTT
TTGGCCGTATCGGTCGCTTATTAGCACGCCTGCTGATTGAACGCACAGGTCGCAGCAATAAGTTAAGATTACGCGCTATC
GTATTACGTGGCGGTAAGAAAGGTGATTTAGAGAAACGTGCCAGTTTATTGCGCCGTGACTCAGTCCATGGGCCTTTCAA
TGGCTCTGTGGAAGTTGACGAAGAGAACAATGCCATCATCGCCAATGGTACCTATATCCAAGTGATTTACGCGAACTCGC
CTGACGAAGTGGATTACACTAAATACGATATCAGCGATGCACTCGTTGTTGATAACACGGGTATTTGGAAAGATGAAGCG
GGTCTTGGTTTACATCTTAAGAGCCCAGGCGCGAGCAAAGTGTTGCTTACAGCTCCTGCAAAAGGCGCTATCAAGAACAT
CGTTTACGGTGTGAATGAAGGCGACATTACCCCAGAAGACATTATCGTTTCTGCGGCAAGCTGTACAACCAACGCCATTA
CGCCAGTACTGAAAGCCGTGAATGATAAATATGGTATTGAGAATGGTCACGTTGAGACGATTCACTCTTATACCAACGAT
CAAAACTTGATTGATAACTATCACACCGCTGACCGCCGTGGCCGCAGTGCACCATTAAACATGGTGATCACTGAAACAGG
CGCCGCGAAAGCCGTTGCTAAAGCACTGCCAGTGTTAGCGGGCAAGTTAACCGGTAACGCGATTCGTGTGCCAACGCCGA
ACGTCTCTATGGCCATCATCAGCATGAACTTGAATGCTGAAACCAGTAAAGATGAGCTGAACGAGTACCTGAAAGATACG
GCGCTGCAATCACCGCTACAAAATCAAATCGATTACACCGACTCTACTGAGATTGTATCGAGCGATTTAGTGGGTTCTCG
CTACGCGGGCGTGATTGATTCACAAGCGACTATCGCAGAAGGCAAACGTGCCATTCTTTATGTATGGTATGACAACGAGT
TTGGTTATAGCTGCCAAGTGGTTGGCGTAATGCAAACTATGTTAGGTTTAACGACGCTATCTCTGCCGGCATAA

Upstream 100 bases:

>100_bases
AGGGTTTTCCCTAAAACCCGCATTAGATTATTGGTCTTTTCGTCATGTTACTCAAACCTTTCAGTACATTTTATTGAAAA
GTGAGATAAAGGATCTGTAA

Downstream 100 bases:

>100_bases
GTTAGCTGCGTAAATCATCAGCGTAGGTTATGCGGAGTCTTCAAAACTGCGCATAATCTTCACATAAAGCGCCCTGCAGG
GCGCTTTTGTTTTTCTATAC

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSADKHLQSWQERFEMAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIEIIKAHRLVRRHVGEKLRLRESFPFVQALSKL
AVKQCKVDIGKLAVNYWRDHTDVSEIENYMAKELADAIDHADDVAPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAI
VLRGGKKGDLEKRASLLRRDSVHGPFNGSVEVDEENNAIIANGTYIQVIYANSPDEVDYTKYDISDALVVDNTGIWKDEA
GLGLHLKSPGASKVLLTAPAKGAIKNIVYGVNEGDITPEDIIVSAASCTTNAITPVLKAVNDKYGIENGHVETIHSYTND
QNLIDNYHTADRRGRSAPLNMVITETGAAKAVAKALPVLAGKLTGNAIRVPTPNVSMAIISMNLNAETSKDELNEYLKDT
ALQSPLQNQIDYTDSTEIVSSDLVGSRYAGVIDSQATIAEGKRAILYVWYDNEFGYSCQVVGVMQTMLGLTTLSLPA

Sequences:

>Translated_477_residues
MSADKHLQSWQERFEMAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIEIIKAHRLVRRHVGEKLRLRESFPFVQALSKL
AVKQCKVDIGKLAVNYWRDHTDVSEIENYMAKELADAIDHADDVAPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAI
VLRGGKKGDLEKRASLLRRDSVHGPFNGSVEVDEENNAIIANGTYIQVIYANSPDEVDYTKYDISDALVVDNTGIWKDEA
GLGLHLKSPGASKVLLTAPAKGAIKNIVYGVNEGDITPEDIIVSAASCTTNAITPVLKAVNDKYGIENGHVETIHSYTND
QNLIDNYHTADRRGRSAPLNMVITETGAAKAVAKALPVLAGKLTGNAIRVPTPNVSMAIISMNLNAETSKDELNEYLKDT
ALQSPLQNQIDYTDSTEIVSSDLVGSRYAGVIDSQATIAEGKRAILYVWYDNEFGYSCQVVGVMQTMLGLTTLSLPA
>Mature_476_residues
SADKHLQSWQERFEMAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIEIIKAHRLVRRHVGEKLRLRESFPFVQALSKLA
VKQCKVDIGKLAVNYWRDHTDVSEIENYMAKELADAIDHADDVAPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIV
LRGGKKGDLEKRASLLRRDSVHGPFNGSVEVDEENNAIIANGTYIQVIYANSPDEVDYTKYDISDALVVDNTGIWKDEAG
LGLHLKSPGASKVLLTAPAKGAIKNIVYGVNEGDITPEDIIVSAASCTTNAITPVLKAVNDKYGIENGHVETIHSYTNDQ
NLIDNYHTADRRGRSAPLNMVITETGAAKAVAKALPVLAGKLTGNAIRVPTPNVSMAIISMNLNAETSKDELNEYLKDTA
LQSPLQNQIDYTDSTEIVSSDLVGSRYAGVIDSQATIAEGKRAILYVWYDNEFGYSCQVVGVMQTMLGLTTLSLPA

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=339, Percent_Identity=35.9882005899705, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI7669492, Length=337, Percent_Identity=36.4985163204748, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1788079, Length=335, Percent_Identity=36.1194029850746, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789295, Length=349, Percent_Identity=32.9512893982808, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17534677, Length=338, Percent_Identity=35.207100591716, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17534679, Length=338, Percent_Identity=34.9112426035503, Blast_Score=171, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=35.5882352941176, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=35.5882352941176, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322409, Length=339, Percent_Identity=37.1681415929204, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322468, Length=339, Percent_Identity=37.4631268436578, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321631, Length=339, Percent_Identity=37.1681415929204, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI85725000, Length=337, Percent_Identity=36.2017804154303, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI22023983, Length=337, Percent_Identity=36.2017804154303, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=36.2017804154303, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=36.2017804154303, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=37.4622356495468, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 52350; Mature: 52219

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADKHLQSWQERFEMAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIEIIKAHRLVRRH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
VGEKLRLRESFPFVQALSKLAVKQCKVDIGKLAVNYWRDHTDVSEIENYMAKELADAIDH
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ADDVAPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIVLRGGKKGDLEKRASLLRRD
HCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
SVHGPFNGSVEVDEENNAIIANGTYIQVIYANSPDEVDYTKYDISDALVVDNTGIWKDEA
CCCCCCCCCEEEECCCCEEEECCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCC
GLGLHLKSPGASKVLLTAPAKGAIKNIVYGVNEGDITPEDIIVSAASCTTNAITPVLKAV
CCEEEECCCCCCEEEEECCCCHHHHHHEEECCCCCCCHHHHEEEEHHCCHHHHHHHHHHH
NDKYGIENGHVETIHSYTNDQNLIDNYHTADRRGRSAPLNMVITETGAAKAVAKALPVLA
HHHCCCCCCCEEEEECCCCCCHHHHCCHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHH
GKLTGNAIRVPTPNVSMAIISMNLNAETSKDELNEYLKDTALQSPLQNQIDYTDSTEIVS
HHCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHH
SDLVGSRYAGVIDSQATIAEGKRAILYVWYDNEFGYSCQVVGVMQTMLGLTTLSLPA
HHCCCCHHCCCCCCCHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SADKHLQSWQERFEMAEAMQPLLGKLYRNQGVEVVVYGKPLLNASTIEIIKAHRLVRRH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
VGEKLRLRESFPFVQALSKLAVKQCKVDIGKLAVNYWRDHTDVSEIENYMAKELADAIDH
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ADDVAPRDVVLYGFGRIGRLLARLLIERTGRSNKLRLRAIVLRGGKKGDLEKRASLLRRD
HCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHC
SVHGPFNGSVEVDEENNAIIANGTYIQVIYANSPDEVDYTKYDISDALVVDNTGIWKDEA
CCCCCCCCCEEEECCCCEEEECCCEEEEEECCCCCCCCCEEECCCCEEEECCCCCCCCCC
GLGLHLKSPGASKVLLTAPAKGAIKNIVYGVNEGDITPEDIIVSAASCTTNAITPVLKAV
CCEEEECCCCCCEEEEECCCCHHHHHHEEECCCCCCCHHHHEEEEHHCCHHHHHHHHHHH
NDKYGIENGHVETIHSYTNDQNLIDNYHTADRRGRSAPLNMVITETGAAKAVAKALPVLA
HHHCCCCCCCEEEEECCCCCCHHHHCCHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHH
GKLTGNAIRVPTPNVSMAIISMNLNAETSKDELNEYLKDTALQSPLQNQIDYTDSTEIVS
HHCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHCCCCCCCHHHHH
SDLVGSRYAGVIDSQATIAEGKRAILYVWYDNEFGYSCQVVGVMQTMLGLTTLSLPA
HHCCCCHHCCCCCCCHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8508805; 10360571; 2401296; 7877172 [H]