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The map label for this gene is ppiB [H]

Identifier: 126174212

GI number: 126174212

Start: 2308169

End: 2308669

Strand: Reverse

Name: ppiB [H]

Synonym: Sbal_1988

Alternate gene names: 126174212

Gene position: 2308669-2308169 (Counterclockwise)

Preceding gene: 126174213

Following gene: 126174210

Centisome position: 45.03

GC content: 47.31

Gene sequence:

>501_bases
ATGATTACATTCAGCACCAATTTAGGCGACATCACCATAGCACTCGACTTTGAACATGCGCCTGTCAGTTCAAAAAACTT
TGTCCGCTATTGTGAAGAAGGCTTCTTTGAACATACGATTTTTCACCGTGTTATCAAAGGTTTTATGATTCAGGGCGGCG
GGTTTACCGCAAAAATGAAAGAAAAGCCGACCCACGAGCCTATCGTGAACGAAGCCAACAAAGGCCTAAGTAACACCATA
GGCACTATCGCTATGGCTCGCACCGATGCGCCTCATTCGGCCACGGCGCAGTTCTTCATTAACACCGCCAATAATGACTT
TTTAGACCACACTGCCACCACCAATAACGGTTGGGGGTATGCGGTATTTGGTAAGGTCACTGCGGGAATGGACATTATCC
AACAGATTGAAAAAGTCAAAACCACCACTGTCGCCGGCCACGAAGACGTGCCCCGCGAACCCATCGTTATCGAGAAAGTG
ACGATTAATATCCAAAGCTGA

Upstream 100 bases:

>100_bases
TCATGATCCCGTACAAAGTCGCGATCCCGTATAAAGTTATGATCTAGTACCAGTCGTGACTTATTAGAAGTAGAAACTCA
TTAAGATAGAAGATATTAGC

Downstream 100 bases:

>100_bases
TCGTTAAAACGATAAGACTTTTCTTTTTAAATAATGAATCGCTCAGTTTTGGCTGAGCGATTCATTATTTTTAGTAGCGG
TTTTTAAAATTAATTAGTTC

Product: peptidyl-prolyl cis-trans isomerase cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MITFSTNLGDITIALDFEHAPVSSKNFVRYCEEGFFEHTIFHRVIKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNTI
GTIAMARTDAPHSATAQFFINTANNDFLDHTATTNNGWGYAVFGKVTAGMDIIQQIEKVKTTTVAGHEDVPREPIVIEKV
TINIQS

Sequences:

>Translated_166_residues
MITFSTNLGDITIALDFEHAPVSSKNFVRYCEEGFFEHTIFHRVIKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNTI
GTIAMARTDAPHSATAQFFINTANNDFLDHTATTNNGWGYAVFGKVTAGMDIIQQIEKVKTTTVAGHEDVPREPIVIEKV
TINIQS
>Mature_166_residues
MITFSTNLGDITIALDFEHAPVSSKNFVRYCEEGFFEHTIFHRVIKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNTI
GTIAMARTDAPHSATAQFFINTANNDFLDHTATTNNGWGYAVFGKVTAGMDIIQQIEKVKTTTVAGHEDVPREPIVIEKV
TINIQS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.7073170731707, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.7073170731707, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=30.2469135802469, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI19557636, Length=141, Percent_Identity=31.9148936170213, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.2517985611511, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI24308049, Length=167, Percent_Identity=30.5389221556886, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=58.2822085889571, Blast_Score=201, Evalue=2e-53,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=53.8461538461538, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=162, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=160, Percent_Identity=33.75, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=161, Percent_Identity=33.5403726708075, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=31.4814814814815, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=29.8780487804878, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=35.9154929577465, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=131, Percent_Identity=32.824427480916, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=31.0975609756098, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=28.6585365853659, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18274; Mature: 18274

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITFSTNLGDITIALDFEHAPVSSKNFVRYCEEGFFEHTIFHRVIKGFMIQGGGFTAKMK
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEECC
EKPTHEPIVNEANKGLSNTIGTIAMARTDAPHSATAQFFINTANNDFLDHTATTNNGWGY
CCCCCCCHHHHHCCCHHHHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEE
AVFGKVTAGMDIIQQIEKVKTTTVAGHEDVPREPIVIEKVTINIQS
EEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MITFSTNLGDITIALDFEHAPVSSKNFVRYCEEGFFEHTIFHRVIKGFMIQGGGFTAKMK
CEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEECC
EKPTHEPIVNEANKGLSNTIGTIAMARTDAPHSATAQFFINTANNDFLDHTATTNNGWGY
CCCCCCCHHHHHCCCHHHHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEE
AVFGKVTAGMDIIQQIEKVKTTTVAGHEDVPREPIVIEKVTINIQS
EEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]