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The map label for this gene is yahK [H]

Identifier: 126172882

GI number: 126172882

Start: 719439

End: 720488

Strand: Direct

Name: yahK [H]

Synonym: Sbal_0633

Alternate gene names: 126172882

Gene position: 719439-720488 (Clockwise)

Preceding gene: 126172881

Following gene: 126172883

Centisome position: 14.03

GC content: 51.05

Gene sequence:

>1050_bases
ATGAAGATTAAAGCTTTTGGTGCAAATGCCAGCCATTTACCGCTGGAACCTATGACGATTACGCGACGCCTACCCGGCGA
GGATGATGTGCAGATCAGCATCGACTACTGCGGCGTGTGTCACTCAGATCTCCATCAGGTTCGTTCGGAATGGGCGGGCA
CTTTATATCCCTGCGTTCCCGGGCACGAGATTGTTGGTCGAGTGACCGCCGTGGGCGGACATGTCTCAAAATTCAACGTG
GGTGACTTGGTTGGCGTGGGTTGCATCGTTGATAGCTGTAAACACTGCCATGAGTGTATTGATGATCAAGAAAATTACTG
CGATCACATGGTGGGTACTTATAACGGCCCAACCCATGACGCTCTTGGACATACGCTCGGTGGCTACGCGGAACAAATCG
TGGTTGATGAACGTTATGTGCTGCGTATCAGTCATCCACAAGAGCAATTAGCGGCCGTGGCTCCACTTCTGTGTGCGGGT
ATCACCACCTATTCTCCGCTGCGCCATTGGCATGCGGGACCGGGTAAAAAAGTTGGTATTGTCGGCATTGGTGGCCTTGG
CCACATGGGGATTAAGCTCGCCCATGCCATGGGGGCTCATGTTGTGGCATTTACCACTTCAGAATCTAAACGTGATGCGG
CCAAAGCCTTGGGTGCTGACGAAGTGGTTGTTTCCAAAAATGCCGATGAAATGGCAAAGCATCTGCAGAGTTTAGATTTG
ATTGTGAATACCGTTGCGGCTCCCCATGATTTGGATGCTTTTTTAAGCTTATTAAAACGCGACGGCACTATGACCTTAGT
TGGCGCGCCTGCAACAAATCATCCTTCGCCCAATGCGTTTAATCTGATCATGAAACGCCGCAGCCTTGCGGGTTCAATGA
TAGGTGGGATCCGTGAAACCCAAGAGATGCTCGATTTTTGTGCTGAGCACAACATAGTGTCGGATATTGAACTGATCCGC
GCTGACGAGATTAACACCGCCTATGAGCGCATGCTGAAGGGCGATGTGAAGTATCGGTTCGTTATCGACAACGCCACGCT
AGCGCGCTAG

Upstream 100 bases:

>100_bases
GAGTGCAACCTTGCTAGCGGCGGCTGCTTTACTCGCGTATTGGACCCAACGTTCAACGCCAGAACCGCTGCTTCACGCTC
AATAATGAAGGAATTTTACT

Downstream 100 bases:

>100_bases
CTGAACCTGAGTGTGGATTATGGGTATTCGATGTTTAACCATTTTGGTCTTACGGATGCCCATGGTTTTATTGCTGTTAA
TGGTCAGCATAGAGGTCGCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKIKAFGANASHLPLEPMTITRRLPGEDDVQISIDYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVTAVGGHVSKFNV
GDLVGVGCIVDSCKHCHECIDDQENYCDHMVGTYNGPTHDALGHTLGGYAEQIVVDERYVLRISHPQEQLAAVAPLLCAG
ITTYSPLRHWHAGPGKKVGIVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRDAAKALGADEVVVSKNADEMAKHLQSLDL
IVNTVAAPHDLDAFLSLLKRDGTMTLVGAPATNHPSPNAFNLIMKRRSLAGSMIGGIRETQEMLDFCAEHNIVSDIELIR
ADEINTAYERMLKGDVKYRFVIDNATLAR

Sequences:

>Translated_349_residues
MKIKAFGANASHLPLEPMTITRRLPGEDDVQISIDYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVTAVGGHVSKFNV
GDLVGVGCIVDSCKHCHECIDDQENYCDHMVGTYNGPTHDALGHTLGGYAEQIVVDERYVLRISHPQEQLAAVAPLLCAG
ITTYSPLRHWHAGPGKKVGIVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRDAAKALGADEVVVSKNADEMAKHLQSLDL
IVNTVAAPHDLDAFLSLLKRDGTMTLVGAPATNHPSPNAFNLIMKRRSLAGSMIGGIRETQEMLDFCAEHNIVSDIELIR
ADEINTAYERMLKGDVKYRFVIDNATLAR
>Mature_349_residues
MKIKAFGANASHLPLEPMTITRRLPGEDDVQISIDYCGVCHSDLHQVRSEWAGTLYPCVPGHEIVGRVTAVGGHVSKFNV
GDLVGVGCIVDSCKHCHECIDDQENYCDHMVGTYNGPTHDALGHTLGGYAEQIVVDERYVLRISHPQEQLAAVAPLLCAG
ITTYSPLRHWHAGPGKKVGIVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRDAAKALGADEVVVSKNADEMAKHLQSLDL
IVNTVAAPHDLDAFLSLLKRDGTMTLVGAPATNHPSPNAFNLIMKRRSLAGSMIGGIRETQEMLDFCAEHNIVSDIELIR
ADEINTAYERMLKGDVKYRFVIDNATLAR

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=316, Percent_Identity=27.5316455696203, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156523966, Length=346, Percent_Identity=24.2774566473988, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=24.2774566473988, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=24.390243902439, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=81.8443804034582, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI87082401, Length=346, Percent_Identity=35.5491329479769, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=27.6729559748428, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788073, Length=285, Percent_Identity=27.719298245614, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788407, Length=277, Percent_Identity=28.8808664259928, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=27.2972972972973, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI226510992, Length=257, Percent_Identity=25.6809338521401, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790045, Length=291, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=26.0606060606061, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=29.9703264094956, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=28.1524926686217, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71988145, Length=342, Percent_Identity=26.6081871345029, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=27.6422764227642, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=27.7628032345013, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=362, Percent_Identity=27.0718232044199, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=238, Percent_Identity=28.9915966386555, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=270, Percent_Identity=27.037037037037, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=320, Percent_Identity=38.125, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=31.6568047337278, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=36.3636363636364, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=31.7784256559767, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=31.7784256559767, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=30.9309309309309, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320033, Length=357, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=347, Percent_Identity=26.8011527377522, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=278, Percent_Identity=28.4172661870504, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737895, Length=366, Percent_Identity=25.6830601092896, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737897, Length=222, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 37712; Mature: 37712

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKAFGANASHLPLEPMTITRRLPGEDDVQISIDYCGVCHSDLHQVRSEWAGTLYPCVP
CEEEEECCCCCCCCCCCHHEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEECCCCC
GHEIVGRVTAVGGHVSKFNVGDLVGVGCIVDSCKHCHECIDDQENYCDHMVGTYNGPTHD
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHH
ALGHTLGGYAEQIVVDERYVLRISHPQEQLAAVAPLLCAGITTYSPLRHWHAGPGKKVGI
HHHHHHCCHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
VGIGGLGHMGIKLAHAMGAHVVAFTTSESKRDAAKALGADEVVVSKNADEMAKHLQSLDL
EEECCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
IVNTVAAPHDLDAFLSLLKRDGTMTLVGAPATNHPSPNAFNLIMKRRSLAGSMIGGIRET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEMLDFCAEHNIVSDIELIRADEINTAYERMLKGDVKYRFVIDNATLAR
HHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKIKAFGANASHLPLEPMTITRRLPGEDDVQISIDYCGVCHSDLHQVRSEWAGTLYPCVP
CEEEEECCCCCCCCCCCHHEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCEECCCCC
GHEIVGRVTAVGGHVSKFNVGDLVGVGCIVDSCKHCHECIDDQENYCDHMVGTYNGPTHD
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHH
ALGHTLGGYAEQIVVDERYVLRISHPQEQLAAVAPLLCAGITTYSPLRHWHAGPGKKVGI
HHHHHHCCHHHHEEECCEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
VGIGGLGHMGIKLAHAMGAHVVAFTTSESKRDAAKALGADEVVVSKNADEMAKHLQSLDL
EEECCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
IVNTVAAPHDLDAFLSLLKRDGTMTLVGAPATNHPSPNAFNLIMKRRSLAGSMIGGIRET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QEMLDFCAEHNIVSDIELIRADEINTAYERMLKGDVKYRFVIDNATLAR
HHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]