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The map label for this gene is mutL [H]

Identifier: 125625245

GI number: 125625245

Start: 2443649

End: 2445619

Strand: Reverse

Name: mutL [H]

Synonym: llmg_2489

Alternate gene names: 125625245

Gene position: 2445619-2443649 (Counterclockwise)

Preceding gene: 125625246

Following gene: 125625244

Centisome position: 96.68

GC content: 37.49

Gene sequence:

>1971_bases
GTGGGAAAAATTATTGAACTAAATGAAGCGCTCGCCAATCAAATTGCTGCTGGAGAGGTGGTTGAGCGGCCTGCTAGTGT
TGTCAAAGAATTAGTCGAAAACTCAATTGATGCTGGAAGCAGTAAAATTATTATCAATGTTGAAGAAGCAGGTTTGCGAT
TAATTGAAGTCATTGATAATGGTTTGGGCTTAGAAAAAGAAGATGTGGCTTTGGCTTTGCGTCGTCATGCGACAAGTAAA
ATCAAAGATTCAGCTGATTTATTTCGAATTAGAACGCTCGGTTTTCGGGGTGAGGCTCTGCCGTCAATCGCTTCTGTCAG
TCAGATGACGATTGAAACAAGTAATGCTCAGGAAGAAGCTGGGACAAAACTGATTGCTAAAGGTGGGACGATTGAAACTT
TAGAACCTCTTGCAAAGCGGTTAGGGACAAAAATTTCTGTTGCGAATCTTTTTTATAATACACCAGCAAGGCTCAAGTAT
ATCAAGTCTTTACAGGCTGAACTTTCTCATATTACAGATATTATCAATCGTTTGAGCCTCGCTCATCCAGAGATTTCTTT
TACTTTAGTTAATGAGGGTAAAGAATTTTTGAAAACGGCGGGAAATGGAGACTTGCGCCAAGTGATTGCTGCAATTTATG
GCATTGGAACGGCGAAAAAAATGCGTGAGATTAATGGCTCGGACTTAGATTTTGAACTGACAGGTTATGTCAGTTTACCC
GAGCTGACAAGAGCGAATCGCAACTATATCACGATTTTGATTAATGGTCGATTTATCAAGAATTTTTTGTTGAATCGAGC
AATTTTAGAAGGTTACGGGAACCGATTGATGGTTGGACGTTTTCCTTTTGCTGTTTTATCAATTAAAATTGACCCTAAAT
TAGCAGATGTCAATGTCCATCCGACAAAACAAGAAGTACGTTTGTCTAAGGAACGTGAATTGATGACTTTAATTTCTAAA
GCGATTGATGAGACCTTATCAGAAGGGGTTTTGATTCCAGAAGCTTTGGAAAATTTGCAAGGTAGAGCCAAGGAAAAGGG
GACTGTTTCTGTTCAAACGGAACTTCCTTTACAGAATAATCCTTTATACTATGACAATGTTCGTCAAGATTTTTTTGTCA
GAGAAGAAGCGATTTTTGAAATCAATAAAAACGATAATTCAGATTCTCTGACTGAACAAAATTCTACTGATTATACAGTT
AATCAGCCAGAAACTGGTTCTGTCAGTGAAAAAATTACGGACAGAACTGTCGAAAGTTCAAATGAATTTACTGACAGAAC
CCCAAAAAATTCTGTCAGTAACTTTGGAGTTGATTTTGATAATATTGAGAAGCTGAGTCAGCAATCAACTTTTCCCCAAC
TAGAATACTTGGCACAATTGCATGCGACTTATTTACTTTGTCAGTCAAAAGAGGGTCTTTATTTGGTTGACCAACATGCG
GCTCAGGAGCGAATCAAGTATGAATATTGGAAAGATAAAATCGGCGAAGTGAGCATGGAGCAACAAATTTTACTTGCGCC
ATATTTATTTACTTTACCCAAAAATGATTTTATTGTTTTAGCTGAGAAAAAGGATTTATTACATGAAGCAGGGGTTTTCT
TGGAAGAATACGGAGAAAATCAATTCATATTAAGAGAGCATCCGATTTGGTTAAAAGAAACTGAGATAGAGAAATCAATT
AATGAAATGATTGATATTATTCTCTCATCAAAAGAATTTTCACTCAAAAAATATCGGCATGATTTAGCCGCAATGGTTGC
TTGTAAAAGCTCAATCAAAGCCAACCATCCCCTTGATGCCGAGTCTGCTAGAGCTTTGCTTAGAGAATTATCAACTTGTA
AAAATCCTTATAGTTGTGCGCATGGACGGCCAACGATTGTCCATTTTTCAGGAGATGACATTCAAAAAATGTTCCGCAGA
ATTCAAGAAACGCATCGTTCAAAAGCGGCCTCTTGGAAAGATTTTGAGTAA

Upstream 100 bases:

>100_bases
CTTGTCTATCATTTTTTGTCAGTAAAAAATGAAAAGCGAGCCCATGCTTTTTGTGTTATAATTAGAATTAATTTTATAAA
AACAAGAGAGCGAGATTATT

Downstream 100 bases:

>100_bases
AAGAAAAGAACTGGCAGCGGTCAGTTAATCAAAAAATTAGAAAAGTAAAAAATGTTTGAATATCTAAATGGAAAATTAGT
TAAAATTTCCCCAACAAATA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSK
IKDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEAGTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKY
IKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLP
ELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVHPTKQEVRLSKERELMTLISK
AIDETLSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNNPLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTV
NQPETGSVSEKITDRTVESSNEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHA
AQERIKYEYWKDKIGEVSMEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSI
NEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLRELSTCKNPYSCAHGRPTIVHFSGDDIQKMFRR
IQETHRSKAASWKDFE

Sequences:

>Translated_656_residues
MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSK
IKDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEAGTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKY
IKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLP
ELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVHPTKQEVRLSKERELMTLISK
AIDETLSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNNPLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTV
NQPETGSVSEKITDRTVESSNEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHA
AQERIKYEYWKDKIGEVSMEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSI
NEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLRELSTCKNPYSCAHGRPTIVHFSGDDIQKMFRR
IQETHRSKAASWKDFE
>Mature_655_residues
GKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKI
KDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEAGTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKYI
KSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLPE
LTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVHPTKQEVRLSKERELMTLISKA
IDETLSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNNPLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTVN
QPETGSVSEKITDRTVESSNEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAA
QERIKYEYWKDKIGEVSMEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSIN
EMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLRELSTCKNPYSCAHGRPTIVHFSGDDIQKMFRRI
QETHRSKAASWKDFE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=336, Percent_Identity=36.3095238095238, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI4505913, Length=339, Percent_Identity=30.3834808259587, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI310128478, Length=339, Percent_Identity=30.3834808259587, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI91992160, Length=262, Percent_Identity=33.206106870229, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI91992162, Length=262, Percent_Identity=33.206106870229, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=27.0516717325228, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=27.0516717325228, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128480, Length=305, Percent_Identity=28.1967213114754, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=28.75, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=31.25, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI1790612, Length=337, Percent_Identity=40.9495548961424, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=35.7366771159875, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17562796, Length=360, Percent_Identity=29.7222222222222, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=34.5132743362832, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=355, Percent_Identity=27.6056338028169, Blast_Score=137, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6325093, Length=560, Percent_Identity=21.6071428571429, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6323063, Length=184, Percent_Identity=30.9782608695652, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=329, Percent_Identity=34.0425531914894, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=28.2122905027933, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 73799; Mature: 73668

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDN
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCHHHHHHHHC
GLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEA
CCCCCHHHHHHHHHHHHHHHHCCCHHHEEHEECCCCCCCCHHHHHHHHHEEECCCCHHHH
GTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSL
CCEEEECCCCHHHHHHHHHHHCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLP
CCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCEECH
ELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVH
HHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCEEECCCCC
PTKQEVRLSKERELMTLISKAIDETLSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCC
PLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTVNQPETGSVSEKITDRTVESS
CEEECCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCC
NEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHA
CCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCEEEEECHH
AQERIKYEYWKDKIGEVSMEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGEN
HHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCC
QFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDA
CEEEECCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ESARALLRELSTCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCHHHHHHHHC
GLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSNAQEEA
CCCCCHHHHHHHHHHHHHHHHCCCHHHEEHEECCCCCCCCHHHHHHHHHEEECCCCHHHH
GTKLIAKGGTIETLEPLAKRLGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSL
CCEEEECCCCHHHHHHHHHHHCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHC
AHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMREINGSDLDFELTGYVSLP
CCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCEECH
ELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAVLSIKIDPKLADVNVH
HHHCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCEEECCCCC
PTKQEVRLSKERELMTLISKAIDETLSEGVLIPEALENLQGRAKEKGTVSVQTELPLQNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCC
PLYYDNVRQDFFVREEAIFEINKNDNSDSLTEQNSTDYTVNQPETGSVSEKITDRTVESS
CEEECCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCC
NEFTDRTPKNSVSNFGVDFDNIEKLSQQSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHA
CCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCEEEEECHH
AQERIKYEYWKDKIGEVSMEQQILLAPYLFTLPKNDFIVLAEKKDLLHEAGVFLEEYGEN
HHHHHHHHHHHHHHCCCCHHHHHHHCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCC
QFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDA
CEEEECCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ESARALLRELSTCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
HHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]