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The map label for this gene is ptpL [H]

Identifier: 125625242

GI number: 125625242

Start: 2441273

End: 2441710

Strand: Reverse

Name: ptpL [H]

Synonym: llmg_2486

Alternate gene names: 125625242

Gene position: 2441710-2441273 (Counterclockwise)

Preceding gene: 125625243

Following gene: 125625241

Centisome position: 96.53

GC content: 34.93

Gene sequence:

>438_bases
ATGGAAAAAATCGTTTTTGTCTGTTTAGGAAATATTTGTCGTAGTCCAATGGCAGAATTTGTCATGAAAAATTTAGTGCT
GAAATCAGAACACGAGTCCGAATTTATTATTGAAAGTCGTGCAACATCTTCTTGGGAGCACGGAAATCCAATTCACAGAG
GTACTCAAGAAAAGCTGAGAGAACAAGGGATTGATTTTGATATCCATAAAAGCAGCCAAAAAATTACTAGCACTGATTTC
TATGCGTTTGATAAAATTATCGCAATGGATGAATCTAACTTAAAAAATCTAAGGGAAATGGCGCCCGATGGAACAGCTCA
TAAAATTGAAATGCTTTTAGATAATGACGTTCCAGACCCTTGGTTTACGGGAGATTTTCAAGAGACCTATCAACTAGTTA
ATGCAGGTTGTCAAAAATTATTAGATAAAATTGTCTAA

Upstream 100 bases:

>100_bases
TTCCTTTTAGAATTCTGTCAGTAATATCTTATGAAATAAGGTATAATAGAATAAATGCCCAAAATTAGTTAATCTATAAA
TTATATAAAGTAAGGAACTC

Downstream 100 bases:

>100_bases
TAAATTTCAAATAAAAAGAACTGATGTGAGAAAATCTCACATTGAAGCTTGACTTTGCGAAAGACAAGGTCTATAATGAT
ACGTATGGAGGCGAGATTTG

Product: protein-tyrosine phosphatase

Products: NA

Alternate protein names: LMPTP [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MEKIVFVCLGNICRSPMAEFVMKNLVLKSEHESEFIIESRATSSWEHGNPIHRGTQEKLREQGIDFDIHKSSQKITSTDF
YAFDKIIAMDESNLKNLREMAPDGTAHKIEMLLDNDVPDPWFTGDFQETYQLVNAGCQKLLDKIV

Sequences:

>Translated_145_residues
MEKIVFVCLGNICRSPMAEFVMKNLVLKSEHESEFIIESRATSSWEHGNPIHRGTQEKLREQGIDFDIHKSSQKITSTDF
YAFDKIIAMDESNLKNLREMAPDGTAHKIEMLLDNDVPDPWFTGDFQETYQLVNAGCQKLLDKIV
>Mature_145_residues
MEKIVFVCLGNICRSPMAEFVMKNLVLKSEHESEFIIESRATSSWEHGNPIHRGTQEKLREQGIDFDIHKSSQKITSTDF
YAFDKIIAMDESNLKNLREMAPDGTAHKIEMLLDNDVPDPWFTGDFQETYQLVNAGCQKLLDKIV

Specific function: Dephosphorylates the phosphotyrosine-containing proteins. Involved in ethanol stress resistance [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=152, Percent_Identity=36.1842105263158, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI6005988, Length=152, Percent_Identity=37.5, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325330, Length=153, Percent_Identity=35.9477124183007, Blast_Score=85, Evalue=6e-18,
Organism=Drosophila melanogaster, GI78706770, Length=150, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78706772, Length=150, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78711846, Length=153, Percent_Identity=36.6013071895425, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI78706766, Length=151, Percent_Identity=31.7880794701987, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI78706768, Length=151, Percent_Identity=31.7880794701987, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648069, Length=137, Percent_Identity=35.036496350365, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78706764, Length=133, Percent_Identity=32.3308270676692, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16637; Mature: 16637

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIVFVCLGNICRSPMAEFVMKNLVLKSEHESEFIIESRATSSWEHGNPIHRGTQEKLR
CCCEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
EQGIDFDIHKSSQKITSTDFYAFDKIIAMDESNLKNLREMAPDGTAHKIEMLLDNDVPDP
HCCCCCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
WFTGDFQETYQLVNAGCQKLLDKIV
CCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKIVFVCLGNICRSPMAEFVMKNLVLKSEHESEFIIESRATSSWEHGNPIHRGTQEKLR
CCCEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHH
EQGIDFDIHKSSQKITSTDFYAFDKIIAMDESNLKNLREMAPDGTAHKIEMLLDNDVPDP
HCCCCCEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
WFTGDFQETYQLVNAGCQKLLDKIV
CCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]