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The map label for this gene is gntZ [H]

Identifier: 125625225

GI number: 125625225

Start: 2427450

End: 2428355

Strand: Reverse

Name: gntZ [H]

Synonym: llmg_2469

Alternate gene names: 125625225

Gene position: 2428355-2427450 (Counterclockwise)

Preceding gene: 125625228

Following gene: 125625224

Centisome position: 96.0

GC content: 38.63

Gene sequence:

>906_bases
ATGAAATTTGGTATGATTGGTTTAGGGAAAATGGGAATGAATCTTGTGAAAAATGCAGTTGATCACGAGATAGAAGTTGT
AGCCTACGATGTTAATGCTGAGGCTGTGGAAGAGGCTGGGAATTATTCAGAAAAAATTACAGCAGTTAAAAGCATTGACG
AATTACTGACAGAATTGTCAGAGCCAAAAATTATTTGGTTGATGCTTCCAGCTGGGAAAGCAACAAATTCAACAATTGAA
TTATTATCAGAGAAGCTGTCAGCAGCTGATATCCTTATTGATGGTGGAAATTCTAATTACAAAGACAACTTAGAACAAAA
TAAATTACTGACAGAAAAAGGAATCAAATTTTTTGATGTTGGAACCTCTGGTGGAATGGCTGGGGCTCGTCAAGGTGGCA
ACTTTATGATAGGTGGCGACGATGAAAATTCTTGGTCAGTGATTGAGCCTATCTTCAAAGCAATTTCAACAGAAAATGGT
TATCTTTATACAGGAAAACTTGGAAGTGGTCATTACTTAAAGATGATTCACAATGGAATCGAGTATGGCATGATGCAAGC
CATTGCTGAGGGTTTTGAAATTTTAGAAGAATCACCATTTGATTATGATTATGAAGCCGTGGCAAAATTATGGAATCACG
GGTCAGTCATCCGAAGCTGGTTGATGGAGCTTGCACAAGATCAATTTTCAAAAGACCCTAAACTTGACCAAATTATTGGC
CGCGTACAATCCTCAGGAGAAGGAAAGTGGACCATTGAAGAAAGTTTAGATTTAGGCGTTCCGGCTCCGGTTATCGCCTT
ATCCCTGATGATGCGCCAACGCTCATTACAAGAAGATACAATGACTGGTAAAGTCGTTGCTGCTTTACGTAATGGTTTTG
GTGGACATGAAGTAGAACAAAAATAA

Upstream 100 bases:

>100_bases
AAATCAGAAAATATTTTACAAAAAATATTGTTGACAAATGAAAAAAAATTACTTATACTAAAGTTAGCAAAAAGAAAGCG
ATACCACGGAGGAAAAAGTG

Downstream 100 bases:

>100_bases
GTTACTGACGAAAAGTTGAGTAGGTCCATAAAAGCTTTGTGTATGGTTATCCTCTGACGGCTTGTTCATTGCACTAGGTT
TCTTAAAATCTACCGAAATG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKFGMIGLGKMGMNLVKNAVDHEIEVVAYDVNAEAVEEAGNYSEKITAVKSIDELLTELSEPKIIWLMLPAGKATNSTIE
LLSEKLSAADILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDENSWSVIEPIFKAISTENG
YLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQDQFSKDPKLDQIIG
RVQSSGEGKWTIEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHEVEQK

Sequences:

>Translated_301_residues
MKFGMIGLGKMGMNLVKNAVDHEIEVVAYDVNAEAVEEAGNYSEKITAVKSIDELLTELSEPKIIWLMLPAGKATNSTIE
LLSEKLSAADILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDENSWSVIEPIFKAISTENG
YLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQDQFSKDPKLDQIIG
RVQSSGEGKWTIEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHEVEQK
>Mature_301_residues
MKFGMIGLGKMGMNLVKNAVDHEIEVVAYDVNAEAVEEAGNYSEKITAVKSIDELLTELSEPKIIWLMLPAGKATNSTIE
LLSEKLSAADILIDGGNSNYKDNLEQNKLLTEKGIKFFDVGTSGGMAGARQGGNFMIGGDDENSWSVIEPIFKAISTENG
YLYTGKLGSGHYLKMIHNGIEYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQDQFSKDPKLDQIIG
RVQSSGEGKWTIEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHEVEQK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=34.020618556701, Blast_Score=141, Evalue=8e-34,
Organism=Escherichia coli, GI1788341, Length=293, Percent_Identity=34.4709897610922, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17542558, Length=291, Percent_Identity=33.6769759450172, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321695, Length=291, Percent_Identity=37.4570446735395, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321977, Length=287, Percent_Identity=36.9337979094077, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24639279, Length=289, Percent_Identity=35.9861591695502, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32996; Mature: 32996

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGMIGLGKMGMNLVKNAVDHEIEVVAYDVNAEAVEEAGNYSEKITAVKSIDELLTELS
CCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
EPKIIWLMLPAGKATNSTIELLSEKLSAADILIDGGNSNYKDNLEQNKLLTEKGIKFFDV
CCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEC
GTSGGMAGARQGGNFMIGGDDENSWSVIEPIFKAISTENGYLYTGKLGSGHYLKMIHNGI
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
EYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQDQFSKDPKLDQIIG
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RVQSSGEGKWTIEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHEVEQ
HHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
K
C
>Mature Secondary Structure
MKFGMIGLGKMGMNLVKNAVDHEIEVVAYDVNAEAVEEAGNYSEKITAVKSIDELLTELS
CCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHCC
EPKIIWLMLPAGKATNSTIELLSEKLSAADILIDGGNSNYKDNLEQNKLLTEKGIKFFDV
CCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCEEEEC
GTSGGMAGARQGGNFMIGGDDENSWSVIEPIFKAISTENGYLYTGKLGSGHYLKMIHNGI
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
EYGMMQAIAEGFEILEESPFDYDYEAVAKLWNHGSVIRSWLMELAQDQFSKDPKLDQIIG
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
RVQSSGEGKWTIEESLDLGVPAPVIALSLMMRQRSLQEDTMTGKVVAALRNGFGGHEVEQ
HHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]