Click here to switch to the map view.

The map label for this gene is coaD

Identifier: 125625200

GI number: 125625200

Start: 2394852

End: 2395352

Strand: Reverse

Name: coaD

Synonym: llmg_2443

Alternate gene names: 125625200

Gene position: 2395352-2394852 (Counterclockwise)

Preceding gene: 125625201

Following gene: 125625199

Centisome position: 94.7

GC content: 34.73

Gene sequence:

>501_bases
ATGACAGAAAAAATTGGACTCTTTACAGGAACTTTTGATCCACTGACAAATGGCCATTTAGATATTATCAAACGTGCTAG
CCAGCATTTTGATCAACTTTATGTTGGAATTTTTAAAAATGACCAGAAAAATCCACTTTTTCCAACGGACAAACGAGTGG
AAATGCTAGAAGAAGCACTGACAAATCTGTCAGTAAATCATAAAGTTAAAGTCATCAAACATGAACGTGATTTGACAGTA
AATATCGCAAAAAAACTTGGCGTGACGGCTATGGTTCGTTCTTTACGTAATAGCCAAGATTTAGAATATGAAAAAAATAT
GTTCTATTTTAATCTGGAGATGACAGGTATTGAAACCCTCTTCTTTCTAGCAAAACCAGAACTTGAACCGCTAAATTCAA
CAAGAATACGAGAATTACATGCTTTCGGGCAAGATGTCAGCGCTTGGGTTCCAGAAAATGTGAGTCGTGAATTAAGGAAA
TTAGATGAACAAAAAAAATAA

Upstream 100 bases:

>100_bases
TGACTAGGCAAAAAACTTATGGAATTTCTAAAATATCAATTTATGAATTTTGACATTTACTGACAGAAATTCTGTCAGTA
AATTAAGAAAGAAAAAAGTA

Downstream 100 bases:

>100_bases
AAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGCCTGATTATTGTCGCTCTCCTTGTTTTAGTGTATCCAACAA
ATTACTATGTGGAAATGCCT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTEKIGLFTGTFDPLTNGHLDIIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEALTNLSVNHKVKVIKHERDLTV
NIAKKLGVTAMVRSLRNSQDLEYEKNMFYFNLEMTGIETLFFLAKPELEPLNSTRIRELHAFGQDVSAWVPENVSRELRK
LDEQKK

Sequences:

>Translated_166_residues
MTEKIGLFTGTFDPLTNGHLDIIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEALTNLSVNHKVKVIKHERDLTV
NIAKKLGVTAMVRSLRNSQDLEYEKNMFYFNLEMTGIETLFFLAKPELEPLNSTRIRELHAFGQDVSAWVPENVSRELRK
LDEQKK
>Mature_165_residues
TEKIGLFTGTFDPLTNGHLDIIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEALTNLSVNHKVKVIKHERDLTVN
IAKKLGVTAMVRSLRNSQDLEYEKNMFYFNLEMTGIETLFFLAKPELEPLNSTRIRELHAFGQDVSAWVPENVSRELRKL
DEQKK

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=157, Percent_Identity=33.7579617834395, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_LACLM (A2RNW2)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001033683.1
- ProteinModelPortal:   A2RNW2
- SMR:   A2RNW2
- STRING:   A2RNW2
- GeneID:   4798324
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_2443
- eggNOG:   COG0669
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- ProtClustDB:   PRK00168
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 19292; Mature: 19161

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKIGLFTGTFDPLTNGHLDIIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEAL
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TNLSVNHKVKVIKHERDLTVNIAKKLGVTAMVRSLRNSQDLEYEKNMFYFNLEMTGIETL
HCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHE
FFLAKPELEPLNSTRIRELHAFGQDVSAWVPENVSRELRKLDEQKK
EEEECCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEKIGLFTGTFDPLTNGHLDIIKRASQHFDQLYVGIFKNDQKNPLFPTDKRVEMLEEAL
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
TNLSVNHKVKVIKHERDLTVNIAKKLGVTAMVRSLRNSQDLEYEKNMFYFNLEMTGIETL
HCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHE
FFLAKPELEPLNSTRIRELHAFGQDVSAWVPENVSRELRKLDEQKK
EEEECCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA