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The map label for this gene is thrC [H]

Identifier: 125625147

GI number: 125625147

Start: 2328911

End: 2330401

Strand: Reverse

Name: thrC [H]

Synonym: llmg_2387

Alternate gene names: 125625147

Gene position: 2330401-2328911 (Counterclockwise)

Preceding gene: 125625148

Following gene: 125625146

Centisome position: 92.13

GC content: 35.48

Gene sequence:

>1491_bases
ATGGTAACTTTTTATCAATCAACACGGGATAAATCAAATAAAAAAGCAGCCTCACAAGCTATCTTGCAAGGTTTGGCAGA
AGACGGTGGACTTTTTGTTCCTGTTGAATTTCCAAAAGTGGACTTAGATTTTAAAAAATTAAAAAATGCTTCTTATCAGG
AAGTTGCTGAACTTGTATTAAAAGCATTTTTTGATGATTTTTCTGCTGATGAAATAAAATTAATGGTGACAAAAGCCTAC
GGAGAAAAATTTGATAGTCCTGAAATTGCACCGCTCAAAAATCTCGGGAATCACTATATTCTTGAACTCTTTCATGGTGA
AACTATCGCTTTTAAAGACATGGCACTTTCTATCTTGCCTCATTTAATGACCCAAGCGGCTAAGAAAAATGGTGTGACCA
ATGAAATTATTATTCTGACGGCGACTTCTGGGGATACAGGAAAAGCAGCTATGGCAGGTTTTGCTGATGTGCCACAGACA
AAAATTATTGTTTTTTATCCTAAAGGTGGAGTCAGCCACATTCAAGAGCAACAAATGCTGACCCAAAAAGGAGCTAATGT
TCACGTTGTTGGAATTGATGGAAATTTTGACCAAGCTCAGACAGCAGTAAAAGAAATGTTTAATAATAAAAGCTTGCATG
ACCAACTTCTGAAGAATCATCAGCAATTTTCATCAGCAAATTCAATGAATATTGGACGTTTGATTCCGCAAGTCGCTTAT
TATATTTATGCTTACGCACAACTGGTCAAAACTGGGCAAATTACTGACGGAGAAAAAATCAATTTTTCAGTTCCGACAGG
AAATTTTGGAAATATTTTAGCCGCTTATTATGCGAAAAAATTGGGATTACCAGTTGGCCAGCTGATTTGTGCCTCAAATA
AAAATAATGTTTTGACTGACTTTTTCAAAACAGGGCTTTATGATAAAAATCGAGAATTTTATGTGACAAGTTCACCGTCA
ATGGATATTTTGGTTTCTTCAAATCTTGAGCGTTTAATTTTTGAATTAACTGACGAGAGTGATGATGAGACTTTGACTTT
ACTGACAGCTTTGTCAGCAGAAGGTCATTATCAAATTTCTAAAAAAATGATGAGTAAGTTACAAGATTTTATAGCTGACT
GGGCATCAGAAGAAGAAATTTCCAAAGAAATTAATGAAACTTTTGAAAATGAAAACTATGTTCTTGACCCCCACACAGCG
GTTGCAAACTATGTCTATCATCAAATTCAACCAAAAGAAAAAACAGTTGTTGTCAGCACTGCCAGCCCTTACAAGTTCCC
TAAAGTTGTTTTAGAAGGACTTCAAAAGTCAGGAACGGACTTGTCAGAGAAGATAGATGATTTTGCTGCCGTTAAATCAC
TTGAAAAACTCAGTGGTATTCCATTACCCAAAGCTGTGTTAGGGCTTGAAAAAGCTGAAATTTTGCATCATACAGTAGTT
CCAGTTCAGGAAATGCAAAAAGAAGTAGAGAAATACCTTGGTTTAAAATGA

Upstream 100 bases:

>100_bases
AATTAATTATTATAAAAAAAGCCACGATGATTCGTGGCTTTTTGCGAGTTTACAGAATATTTGTTATAATTATAAAAAAT
GTGATTGGGGAATAAATATC

Downstream 100 bases:

>100_bases
AAACAAATAAAGAAATATTAAAATTCGCCCTTCCTGCGATTATTGAAAATTTCTTGCAAATGTTAGTTGGTGTGAGTGAT
ACAATGATTGTTGCTCACCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MVTFYQSTRDKSNKKAASQAILQGLAEDGGLFVPVEFPKVDLDFKKLKNASYQEVAELVLKAFFDDFSADEIKLMVTKAY
GEKFDSPEIAPLKNLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIIILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGANVHVVGIDGNFDQAQTAVKEMFNNKSLHDQLLKNHQQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEKINFSVPTGNFGNILAAYYAKKLGLPVGQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDESDDETLTLLTALSAEGHYQISKKMMSKLQDFIADWASEEEISKEINETFENENYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLQKSGTDLSEKIDDFAAVKSLEKLSGIPLPKAVLGLEKAEILHHTVV
PVQEMQKEVEKYLGLK

Sequences:

>Translated_496_residues
MVTFYQSTRDKSNKKAASQAILQGLAEDGGLFVPVEFPKVDLDFKKLKNASYQEVAELVLKAFFDDFSADEIKLMVTKAY
GEKFDSPEIAPLKNLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIIILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGANVHVVGIDGNFDQAQTAVKEMFNNKSLHDQLLKNHQQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEKINFSVPTGNFGNILAAYYAKKLGLPVGQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDESDDETLTLLTALSAEGHYQISKKMMSKLQDFIADWASEEEISKEINETFENENYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLQKSGTDLSEKIDDFAAVKSLEKLSGIPLPKAVLGLEKAEILHHTVV
PVQEMQKEVEKYLGLK
>Mature_496_residues
MVTFYQSTRDKSNKKAASQAILQGLAEDGGLFVPVEFPKVDLDFKKLKNASYQEVAELVLKAFFDDFSADEIKLMVTKAY
GEKFDSPEIAPLKNLGNHYILELFHGETIAFKDMALSILPHLMTQAAKKNGVTNEIIILTATSGDTGKAAMAGFADVPQT
KIIVFYPKGGVSHIQEQQMLTQKGANVHVVGIDGNFDQAQTAVKEMFNNKSLHDQLLKNHQQFSSANSMNIGRLIPQVAY
YIYAYAQLVKTGQITDGEKINFSVPTGNFGNILAAYYAKKLGLPVGQLICASNKNNVLTDFFKTGLYDKNREFYVTSSPS
MDILVSSNLERLIFELTDESDDETLTLLTALSAEGHYQISKKMMSKLQDFIADWASEEEISKEINETFENENYVLDPHTA
VANYVYHQIQPKEKTVVVSTASPYKFPKVVLEGLQKSGTDLSEKIDDFAAVKSLEKLSGIPLPKAVLGLEKAEILHHTVV
PVQEMQKEVEKYLGLK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=444, Percent_Identity=42.5675675675676, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=31.8077803203661, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1786185, Length=461, Percent_Identity=29.9349240780911, Blast_Score=185, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=36.3247863247863, Blast_Score=269, Evalue=6e-73,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55082; Mature: 55082

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFYQSTRDKSNKKAASQAILQGLAEDGGLFVPVEFPKVDLDFKKLKNASYQEVAELVL
CCEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHH
KAFFDDFSADEIKLMVTKAYGEKFDSPEIAPLKNLGNHYILELFHGETIAFKDMALSILP
HHHHCCCCCCCEEEEEEEHHCCCCCCCCCCHHHHCCCEEEEEEECCCEEEHHHHHHHHHH
HLMTQAAKKNGVTNEIIILTATSGDTGKAAMAGFADVPQTKIIVFYPKGGVSHIQEQQML
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
TQKGANVHVVGIDGNFDQAQTAVKEMFNNKSLHDQLLKNHQQFSSANSMNIGRLIPQVAY
HHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YIYAYAQLVKTGQITDGEKINFSVPTGNFGNILAAYYAKKLGLPVGQLICASNKNNVLTD
HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHH
FFKTGLYDKNREFYVTSSPSMDILVSSNLERLIFELTDESDDETLTLLTALSAEGHYQIS
HHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEHHCCCCCHHHH
KKMMSKLQDFIADWASEEEISKEINETFENENYVLDPHTAVANYVYHQIQPKEKTVVVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEC
ASPYKFPKVVLEGLQKSGTDLSEKIDDFAAVKSLEKLSGIPLPKAVLGLEKAEILHHTVV
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCC
PVQEMQKEVEKYLGLK
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTFYQSTRDKSNKKAASQAILQGLAEDGGLFVPVEFPKVDLDFKKLKNASYQEVAELVL
CCEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCHHHHHHHHH
KAFFDDFSADEIKLMVTKAYGEKFDSPEIAPLKNLGNHYILELFHGETIAFKDMALSILP
HHHHCCCCCCCEEEEEEEHHCCCCCCCCCCHHHHCCCEEEEEEECCCEEEHHHHHHHHHH
HLMTQAAKKNGVTNEIIILTATSGDTGKAAMAGFADVPQTKIIVFYPKGGVSHIQEQQML
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
TQKGANVHVVGIDGNFDQAQTAVKEMFNNKSLHDQLLKNHQQFSSANSMNIGRLIPQVAY
HHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YIYAYAQLVKTGQITDGEKINFSVPTGNFGNILAAYYAKKLGLPVGQLICASNKNNVLTD
HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCHHHH
FFKTGLYDKNREFYVTSSPSMDILVSSNLERLIFELTDESDDETLTLLTALSAEGHYQIS
HHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCEEEEEHHCCCCCHHHH
KKMMSKLQDFIADWASEEEISKEINETFENENYVLDPHTAVANYVYHQIQPKEKTVVVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCCEEEEEC
ASPYKFPKVVLEGLQKSGTDLSEKIDDFAAVKSLEKLSGIPLPKAVLGLEKAEILHHTVV
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHCC
PVQEMQKEVEKYLGLK
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]