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The map label for this gene is pepO2 [H]

Identifier: 125624763

GI number: 125624763

Start: 1972038

End: 1973921

Strand: Direct

Name: pepO2 [H]

Synonym: llmg_1985

Alternate gene names: 125624763

Gene position: 1972038-1973921 (Clockwise)

Preceding gene: 125624762

Following gene: 125624766

Centisome position: 77.96

GC content: 36.68

Gene sequence:

>1884_bases
ATGACTAGAGTTCAAGATGATTTATTTGCTACTGTTAATGCAGACTGGTTAAAAGAAGCACAAATTCCAGCTGACAAGCC
CAGAATTTCAGCATTTGATGAATTAGTTTTAAAAAATGAAAAGAATTTAGCTCATGATTTAACTGAGTTATCCAAAAATC
TTCCTACTGATAATCCAGAATTACTTGAGGCTATCAAGTTTTATAATAAAGCGGGAGATTGGGAAAAGAGAGAGCAAGCT
GATTTTTCTGCTGTAAAAGCAGAACTTGCCAAAGTTGAAACTTTACAGTCTTTCAAAGATTTTCAGGAAAATCTCAGTCA
ACTTATTCTCCATTCACAAACTTCTGTTCCTTTCTCTTTTAGTGTTGAACCAGATATGAAAGACGCGATTCACTACTCTC
TTGGATTTTCTGGACCAGGCTTACTTTTACCTGATACTAGTTATTATGATGAAAAACATCCTCGAAAGAAAGAATTACTT
GATTTTTGGACGAAAAATACTGCAGAAATTTTAGCTCGCTTTGAAGTGGAAAATGCTGAAGAAATTGCCCAAAATTCCGT
CAAATTCGATGAGCTTTTAGTTCCGTCAGCAAATACTTCTGAAGAGTGGGCAAAATATGCTGAGCTTTATCATCCAATTG
CTACTGACAGCTTTGTCAGTGAAATTACCAATCTAAACTTTAAAAGTCTAATTAATGATTTAGTAAAAACAGAACCTGAT
AAAATCATCGTGTACGAAGACCGCTTTTATGAAAACTTCGATTCACTTGTAAATGAAGAAAACTGGTCACTGATTAAAGC
TTGGATGCTGACAAAAGTTGCCCGTCGCGCTACTTCTTTCTTAACTGAAGATTTACGAATCCTTGGTGGGGCTTATGGTC
GTTTCCTTTCAAATGTTCAAGAAGCAAGAAGTCAAGAAAAACATCAACTTGATTTGACCGAATCATATTTCAGCCAAGTT
ATTGGTTTATTCTATGGTCAAAAATATTTTGGAGAAGCTGCAAAAGCCGACGTAAAACGGATGGTTGCGGCAATGATTAA
AGTTTACCAAGAACGATTACGTAAAAATGATTGGCTCAGTCAAGAAACTGCTGAAAAAGCAATTGAAAAATTAGATGCCA
TCACACCTTTTATTGGTTTCCCTGACAAATTACCTGAAATTTATCGTCGCTTAAAAACGACTTCTGGTTCTCTTTACGAA
GATGCCGTTAAATTTGATGAAATTTTGACTGCTCGAACCTTTGAAAAATTCTCAGAAGATGTGGATAAAACAACTTGGCA
TATGCCAGCTCATATGGTCAATGCTTATTACAGTCCAGATAGTAATACAATTGTTTTTCCTGCAGCTATCCTCCAAGCTC
CATTCTATTCTCTTGACCAATCATCATCACAAAACTATGGTGGAATTGGTGCAGTTATCGCCCATGAAATCTCTCATGCT
TTCGATAATAACGGTGCCCAATTCGATAAAGAAGGGAATTTGAACAAGTGGTGGTTAGATAAAGACTACGAAGCCTTTGA
AGAAAAACAAAAAGAAATGATTGAGCTCTTTGATGGCATTGAAACTGAAGCTGGTCCAGCAAACGGAAAACTCATTGTGT
CAGAAAATATTGCTGACCAAGGTGGAATCACTGCTGCGCTAACCGCAGCCAAAGAGGAAGATGATGTTGATTTGAAAGCC
TTCTTTAGCCAATGGGCTAAAATTTGGCGCATGAAAGCAAGTACAGAATTCCAACAAATGCTTTTATCAATGGATGTCCA
TGCTCCTGCTAAGCTCCGTGCCAATATTCCACCAACAAATCTTGAAGAATTTTATGAAACTTTTGATGTCAAAGAAACAG
ACCAAATGTATCGTGCACCAGAAAAACGCCTTAAAATCTGGTAA

Upstream 100 bases:

>100_bases
TTAATTTTCATGGCTTTAAAAAGTACTGATAGAATCGTCAGTGCTTTTTATGCAAGTGTGATATAATGTAAAAAATATCC
ATAATCTTAGGAGGTCGAAT

Downstream 100 bases:

>100_bases
TTAAATTTATAAAAAAAGTACCTCTTCTAGAAGTACTTTTTTTATCTATCAAAGCAGTTCATCTTCGATAACTATTTTCC
CTTGAGTTGTAAATGAAACT

Product: putative neutral endopeptidase O2

Products: NA

Alternate protein names: Endopeptidase O [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTRVQDDLFATVNADWLKEAQIPADKPRISAFDELVLKNEKNLAHDLTELSKNLPTDNPELLEAIKFYNKAGDWEKREQA
DFSAVKAELAKVETLQSFKDFQENLSQLILHSQTSVPFSFSVEPDMKDAIHYSLGFSGPGLLLPDTSYYDEKHPRKKELL
DFWTKNTAEILARFEVENAEEIAQNSVKFDELLVPSANTSEEWAKYAELYHPIATDSFVSEITNLNFKSLINDLVKTEPD
KIIVYEDRFYENFDSLVNEENWSLIKAWMLTKVARRATSFLTEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQV
IGLFYGQKYFGEAAKADVKRMVAAMIKVYQERLRKNDWLSQETAEKAIEKLDAITPFIGFPDKLPEIYRRLKTTSGSLYE
DAVKFDEILTARTFEKFSEDVDKTTWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLDQSSSQNYGGIGAVIAHEISHA
FDNNGAQFDKEGNLNKWWLDKDYEAFEEKQKEMIELFDGIETEAGPANGKLIVSENIADQGGITAALTAAKEEDDVDLKA
FFSQWAKIWRMKASTEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDQMYRAPEKRLKIW

Sequences:

>Translated_627_residues
MTRVQDDLFATVNADWLKEAQIPADKPRISAFDELVLKNEKNLAHDLTELSKNLPTDNPELLEAIKFYNKAGDWEKREQA
DFSAVKAELAKVETLQSFKDFQENLSQLILHSQTSVPFSFSVEPDMKDAIHYSLGFSGPGLLLPDTSYYDEKHPRKKELL
DFWTKNTAEILARFEVENAEEIAQNSVKFDELLVPSANTSEEWAKYAELYHPIATDSFVSEITNLNFKSLINDLVKTEPD
KIIVYEDRFYENFDSLVNEENWSLIKAWMLTKVARRATSFLTEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQV
IGLFYGQKYFGEAAKADVKRMVAAMIKVYQERLRKNDWLSQETAEKAIEKLDAITPFIGFPDKLPEIYRRLKTTSGSLYE
DAVKFDEILTARTFEKFSEDVDKTTWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLDQSSSQNYGGIGAVIAHEISHA
FDNNGAQFDKEGNLNKWWLDKDYEAFEEKQKEMIELFDGIETEAGPANGKLIVSENIADQGGITAALTAAKEEDDVDLKA
FFSQWAKIWRMKASTEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDQMYRAPEKRLKIW
>Mature_626_residues
TRVQDDLFATVNADWLKEAQIPADKPRISAFDELVLKNEKNLAHDLTELSKNLPTDNPELLEAIKFYNKAGDWEKREQAD
FSAVKAELAKVETLQSFKDFQENLSQLILHSQTSVPFSFSVEPDMKDAIHYSLGFSGPGLLLPDTSYYDEKHPRKKELLD
FWTKNTAEILARFEVENAEEIAQNSVKFDELLVPSANTSEEWAKYAELYHPIATDSFVSEITNLNFKSLINDLVKTEPDK
IIVYEDRFYENFDSLVNEENWSLIKAWMLTKVARRATSFLTEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQVI
GLFYGQKYFGEAAKADVKRMVAAMIKVYQERLRKNDWLSQETAEKAIEKLDAITPFIGFPDKLPEIYRRLKTTSGSLYED
AVKFDEILTARTFEKFSEDVDKTTWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLDQSSSQNYGGIGAVIAHEISHAF
DNNGAQFDKEGNLNKWWLDKDYEAFEEKQKEMIELFDGIETEAGPANGKLIVSENIADQGGITAALTAAKEEDDVDLKAF
FSQWAKIWRMKASTEFQQMLLSMDVHAPAKLRANIPPTNLEEFYETFDVKETDQMYRAPEKRLKIW

Specific function: Endopeptidase with broad substrate specificity for several oligopeptides [H]

COG id: COG3590

COG function: function code O; Predicted metalloendopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M13 family [H]

Homologues:

Organism=Homo sapiens, GI164519136, Length=659, Percent_Identity=26.5553869499241, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI4503443, Length=659, Percent_Identity=26.5553869499241, Blast_Score=233, Evalue=6e-61,
Organism=Homo sapiens, GI164519138, Length=659, Percent_Identity=26.5553869499241, Blast_Score=233, Evalue=6e-61,
Organism=Homo sapiens, GI164519140, Length=659, Percent_Identity=26.5553869499241, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI239049391, Length=675, Percent_Identity=25.9259259259259, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI82617560, Length=660, Percent_Identity=23.9393939393939, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI153945761, Length=660, Percent_Identity=23.9393939393939, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI153945836, Length=660, Percent_Identity=23.9393939393939, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI153945771, Length=660, Percent_Identity=23.9393939393939, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI157426891, Length=674, Percent_Identity=22.8486646884273, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI116256333, Length=689, Percent_Identity=26.1248185776488, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI116256331, Length=689, Percent_Identity=26.1248185776488, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI116256329, Length=689, Percent_Identity=26.1248185776488, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI116256327, Length=689, Percent_Identity=26.1248185776488, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI90403592, Length=513, Percent_Identity=23.3918128654971, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4557691, Length=357, Percent_Identity=24.0896358543417, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI86562497, Length=685, Percent_Identity=26.8613138686131, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25148650, Length=675, Percent_Identity=25.4814814814815, Blast_Score=189, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17533333, Length=404, Percent_Identity=27.7227722772277, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32563993, Length=310, Percent_Identity=30.9677419354839, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17564342, Length=341, Percent_Identity=29.6187683284457, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71987442, Length=546, Percent_Identity=24.1758241758242, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17534401, Length=322, Percent_Identity=27.3291925465839, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17570047, Length=585, Percent_Identity=22.7350427350427, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71998977, Length=297, Percent_Identity=25.5892255892256, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71998975, Length=297, Percent_Identity=25.5892255892256, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71988640, Length=237, Percent_Identity=27.4261603375527, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994787, Length=329, Percent_Identity=23.4042553191489, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532485, Length=314, Percent_Identity=24.8407643312102, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17533319, Length=355, Percent_Identity=23.0985915492958, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24643425, Length=664, Percent_Identity=24.6987951807229, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI45551938, Length=536, Percent_Identity=25, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45550777, Length=536, Percent_Identity=25, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24640050, Length=662, Percent_Identity=24.1691842900302, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24640052, Length=662, Percent_Identity=24.1691842900302, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737761, Length=403, Percent_Identity=29.5285359801489, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24650487, Length=405, Percent_Identity=22.962962962963, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI221474862, Length=365, Percent_Identity=24.9315068493151, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI281362760, Length=354, Percent_Identity=26.5536723163842, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650765, Length=269, Percent_Identity=26.7657992565056, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24650885, Length=391, Percent_Identity=25.8312020460358, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650889, Length=349, Percent_Identity=25.214899713467, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355943, Length=338, Percent_Identity=23.3727810650888, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24641622, Length=203, Percent_Identity=31.5270935960591, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000718
- InterPro:   IPR018497
- InterPro:   IPR008753 [H]

Pfam domain/function: PF01431 Peptidase_M13; PF05649 Peptidase_M13_N [H]

EC number: NA

Molecular weight: Translated: 71883; Mature: 71752

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVQDDLFATVNADWLKEAQIPADKPRISAFDELVLKNEKNLAHDLTELSKNLPTDNPE
CCCCCCHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHH
LLEAIKFYNKAGDWEKREQADFSAVKAELAKVETLQSFKDFQENLSQLILHSQTSVPFSF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SVEPDMKDAIHYSLGFSGPGLLLPDTSYYDEKHPRKKELLDFWTKNTAEILARFEVENAE
ECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHH
EIAQNSVKFDELLVPSANTSEEWAKYAELYHPIATDSFVSEITNLNFKSLINDLVKTEPD
HHHHCCCCHHHEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCC
KIIVYEDRFYENFDSLVNEENWSLIKAWMLTKVARRATSFLTEDLRILGGAYGRFLSNVQ
EEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARSQEKHQLDLTESYFSQVIGLFYGQKYFGEAAKADVKRMVAAMIKVYQERLRKNDWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QETAEKAIEKLDAITPFIGFPDKLPEIYRRLKTTSGSLYEDAVKFDEILTARTFEKFSED
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDKTTWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLDQSSSQNYGGIGAVIAHEISHA
HHHHHHHCCHHHHHHEECCCCCEEEEHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHH
FDNNGAQFDKEGNLNKWWLDKDYEAFEEKQKEMIELFDGIETEAGPANGKLIVSENIADQ
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
GGITAALTAAKEEDDVDLKAFFSQWAKIWRMKASTEFQQMLLSMDVHAPAKLRANIPPTN
CCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
LEEFYETFDVKETDQMYRAPEKRLKIW
HHHHHHHCCCCHHHHHHHCCHHHCCCC
>Mature Secondary Structure 
TRVQDDLFATVNADWLKEAQIPADKPRISAFDELVLKNEKNLAHDLTELSKNLPTDNPE
CCCCCHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHH
LLEAIKFYNKAGDWEKREQADFSAVKAELAKVETLQSFKDFQENLSQLILHSQTSVPFSF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
SVEPDMKDAIHYSLGFSGPGLLLPDTSYYDEKHPRKKELLDFWTKNTAEILARFEVENAE
ECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHH
EIAQNSVKFDELLVPSANTSEEWAKYAELYHPIATDSFVSEITNLNFKSLINDLVKTEPD
HHHHCCCCHHHEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCC
KIIVYEDRFYENFDSLVNEENWSLIKAWMLTKVARRATSFLTEDLRILGGAYGRFLSNVQ
EEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARSQEKHQLDLTESYFSQVIGLFYGQKYFGEAAKADVKRMVAAMIKVYQERLRKNDWLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QETAEKAIEKLDAITPFIGFPDKLPEIYRRLKTTSGSLYEDAVKFDEILTARTFEKFSED
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDKTTWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLDQSSSQNYGGIGAVIAHEISHA
HHHHHHHCCHHHHHHEECCCCCEEEEHHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHH
FDNNGAQFDKEGNLNKWWLDKDYEAFEEKQKEMIELFDGIETEAGPANGKLIVSENIADQ
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCC
GGITAALTAAKEEDDVDLKAFFSQWAKIWRMKASTEFQQMLLSMDVHAPAKLRANIPPTN
CCCEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCC
LEEFYETFDVKETDQMYRAPEKRLKIW
HHHHHHHCCCCHHHHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8244921; 11337471 [H]