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The map label for this gene is pepP [H]

Identifier: 125624666

GI number: 125624666

Start: 1863463

End: 1864521

Strand: Reverse

Name: pepP [H]

Synonym: llmg_1881

Alternate gene names: 125624666

Gene position: 1864521-1863463 (Counterclockwise)

Preceding gene: 125624667

Following gene: 125624665

Centisome position: 73.71

GC content: 36.36

Gene sequence:

>1059_bases
ATGAGAATTGAAAAATTAAAAGTAAAAATGCTGACAGAAAATATTGATAGTTTATTGATTACTGATATGAAAAATATTTT
TTATTTGACAGGATTTTCTGGAACAGCGGGTACAGTTTTTTTGACCCAAAAGCGCAATATTTTTATGACAGACAGTCGTT
ACAGTGAGATGGCGCGTGGCTTAATCAAAAATTTTGAAATTATTGAGACGAGAGACCCTATCAGTTTACTGACAGAATTA
TCAGCAAGTGAATCAGTTAAAAATATGGCTTTTGAGGAAACAGTCGATTATGCTTTCTTTAAAAGGTTATCCAAGGCGGC
CACAAAATTAGACCTTTTTTCTACCAGCAATTTTGTTTTGGAACTTCGCCAAATCAAAGACGAATCAGAAATAAGTTTGA
TAAAAAAAGCCTGTGAAATTGCTGACGAAGCCTTTATGTCAGCTCTAAGATTTATTGAACCAGGCCGAACTGAAATCGAA
GTTGCTAATTTTCTTGATTTTAAAATGCGTGATTTAGAGGCGAGCGGAATTTCTTTTGAAACGATTGTTGCCTCTGGAAA
ACGAAGCAGTTTACCGCATGGCGTTGCGACGAGTAAAATGATTCAATTTGGCGATCCAGTAACCATTGATTTTGGTTGTT
ATTATGAGCATTATGCTAGCGATATGACCAGAACAATCTTTGTTGGCTCTGTCGATGACAAAATGCGAACAATCTATGAG
ACCGTTCGTAAAGCTAATGAGGCACTCATCAAACAAGTTAAAGCAGGGATGACTTATGCACAATACGATAATATCCCACG
AGAAGTTATTGAAAAAGCTGATTTTGGGCAATATTTTACGCATGGAATTGGTCATGGTCTTGGTTTAGATGTTCATGAAA
TTCCTTATTTTAATCAGTCGATGACCGAAAACCAACTAAGATCCGGAATGGTAATTACTGATGAGCCGGGAATTTATCTT
CCTGAATTTGGGGGAGTTAGAATTGAAGATGACTTATTAGTGACAGAAAATGGCTGTGAAGTCCTGACAAAAGCGCCAAA
AGAGCTTATCGTTATTTGA

Upstream 100 bases:

>100_bases
TTAAAAGAAAACGTTAACTCATGTTAGCGTTTTTGTGTTATCATGGAAGAAAATGATGAGGTCATTCGATCATTTAATTT
TATATTTAAAGGAGAGCAAA

Downstream 100 bases:

>100_bases
AAAAAGCAATAACTTGTGATAAAATAAGATGTTAAATCCTGTCATTTCACTTCTTTTGTGTGCAGAAAATTACTGACAAA
AAGAAAAAAGGCAGAATATC

Product: aminopeptidase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRIEKLKVKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTQKRNIFMTDSRYSEMARGLIKNFEIIETRDPISLLTEL
SASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSNFVLELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYFNQSMTENQLRSGMVITDEPGIYL
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI

Sequences:

>Translated_352_residues
MRIEKLKVKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTQKRNIFMTDSRYSEMARGLIKNFEIIETRDPISLLTEL
SASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSNFVLELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYFNQSMTENQLRSGMVITDEPGIYL
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
>Mature_352_residues
MRIEKLKVKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTQKRNIFMTDSRYSEMARGLIKNFEIIETRDPISLLTEL
SASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSNFVLELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIE
VANFLDFKMRDLEASGISFETIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
TVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYFNQSMTENQLRSGMVITDEPGIYL
PEFGGVRIEDDLLVTENGCEVLTKAPKELIVI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=275, Percent_Identity=29.4545454545455, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI260593665, Length=293, Percent_Identity=25.938566552901, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI149589008, Length=293, Percent_Identity=25.938566552901, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI260593663, Length=231, Percent_Identity=27.7056277056277, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI164420681, Length=274, Percent_Identity=27.3722627737226, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=25.7028112449799, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI264681563, Length=189, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI93141226, Length=253, Percent_Identity=29.6442687747036, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788728, Length=358, Percent_Identity=36.0335195530726, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789275, Length=281, Percent_Identity=31.3167259786477, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790282, Length=309, Percent_Identity=25.5663430420712, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=28.0821917808219, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71989583, Length=294, Percent_Identity=24.8299319727891, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509539, Length=362, Percent_Identity=24.3093922651934, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321118, Length=281, Percent_Identity=27.7580071174377, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320922, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323273, Length=266, Percent_Identity=27.0676691729323, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322999, Length=178, Percent_Identity=34.2696629213483, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920384, Length=273, Percent_Identity=30.7692307692308, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21357079, Length=290, Percent_Identity=27.9310344827586, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=23.5059760956175, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39776; Mature: 39776

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEKLKVKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTQKRNIFMTDSRYSEMARG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECHHHHHHHHH
LIKNFEIIETRDPISLLTELSASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSNFVL
HHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIEVANFLDFKMRDLEASGISFE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCCHH
TIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
HHEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEEEECCCHHHHHHHH
TVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYFNQS
HHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCCCH
MTENQLRSGMVITDEPGIYLPEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
HCHHHHHCCEEEECCCCEECCCCCCEEEECCEEEECCCCHHHHCCCCCEEEC
>Mature Secondary Structure
MRIEKLKVKMLTENIDSLLITDMKNIFYLTGFSGTAGTVFLTQKRNIFMTDSRYSEMARG
CCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECHHHHHHHHH
LIKNFEIIETRDPISLLTELSASESVKNMAFEETVDYAFFKRLSKAATKLDLFSTSNFVL
HHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ELRQIKDESEISLIKKACEIADEAFMSALRFIEPGRTEIEVANFLDFKMRDLEASGISFE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCCCHH
TIVASGKRSSLPHGVATSKMIQFGDPVTIDFGCYYEHYASDMTRTIFVGSVDDKMRTIYE
HHEECCCCCCCCCCHHHHHHHCCCCCEEEEECCHHHHHHCCCEEEEEEECCCHHHHHHHH
TVRKANEALIKQVKAGMTYAQYDNIPREVIEKADFGQYFTHGIGHGLGLDVHEIPYFNQS
HHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCCCH
MTENQLRSGMVITDEPGIYLPEFGGVRIEDDLLVTENGCEVLTKAPKELIVI
HCHHHHHCCEEEECCCCEECCCCCCEEEECCEEEECCCCHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]