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The map label for this gene is rnc [H]

Identifier: 125624543

GI number: 125624543

Start: 1738610

End: 1739305

Strand: Reverse

Name: rnc [H]

Synonym: llmg_1753

Alternate gene names: 125624543

Gene position: 1739305-1738610 (Counterclockwise)

Preceding gene: 125624544

Following gene: 125624542

Centisome position: 68.76

GC content: 36.78

Gene sequence:

>696_bases
ATGCTCAAGCTTCAAAAAAAATTAAAAAATGATTACGGATTAGTCTTCAATGATGAATATTTATTAAAAACAGCTTTTAC
ACACTCTTCATTTACAAATGAAGAACGGCTCCCAAAGATTGCAAACAATGAACGTTTGGAATTTTTGGGAGACGTTGCCC
TATCTTTGGTTATTTCTGATTATCTTTATCGGACTTATCCTGAAAAATTAGAGGGAGAACTTTCCAAAATGCGCTCAAGC
ATTGTTCGGACAGAATCACTTGCTAATTTTTCACGCTCATGCGGTTTTGGTGAGTTCTTGCGATTAGGTCATGGTGAAGA
AAAAATGGGTGGTCGTGACCGCGAAACAACACTAGAGAACCTTTTTGAGGCTTTTTTAGGTGCGCTTTTTATTGACCAAG
GAATGGATGAAGTTCGTAAATTTATCCAACATGTAGTCATTCCTCACGTTAAAAATGATGATTATGTTAAAGTGATTGAC
TATAAAACAGAACTTCAAGAAGTGTTACAAATTGGTGGAGAAACAACGATTAGCTACAAGATTCTGAAAGAAGAAGGGCC
AGCTCATGACCGTTCTTTTGTGGCCGCGGTTTTTAACAATGGTAAAGAACTCGGACGAGGGCTTGGAAAATCTAAAAAAG
TTGCAGAACAAAAAGCAGCAGAAAATGCAATAAAAGGGCAAAACCATGTATCTTAA

Upstream 100 bases:

>100_bases
AGTCCCGTTCCACAGGGAAAGGCATACAAAAAAGGTTTTTTTTGGTATAATAAGGGATAAAACTAAAAATTAAGAGAAGT
TTTAAGTGAAGGAGATTTTT

Downstream 100 bases:

>100_bases
AAAAATGGAAATTGTCGGCTTCAAATCTTTTGCCGATAAGACTAAAGTTGAATTTGATAAAGGGATAACCGCAGTTGTCG
GTCCAAATGGTTCTGGGAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLKLQKKLKNDYGLVFNDEYLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS

Sequences:

>Translated_231_residues
MLKLQKKLKNDYGLVFNDEYLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
>Mature_231_residues
MLKLQKKLKNDYGLVFNDEYLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISDYLYRTYPEKLEGELSKMRSS
IVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLENLFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVID
YKTELQEVLQIGGETTISYKILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=236, Percent_Identity=32.2033898305085, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI155030236, Length=236, Percent_Identity=32.2033898305085, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788920, Length=215, Percent_Identity=38.1395348837209, Blast_Score=121, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=34.2222222222222, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323895, Length=206, Percent_Identity=27.6699029126214, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26185; Mature: 26185

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLQKKLKNDYGLVFNDEYLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISD
CCCHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLYRTYPEKLEGELSKMRSSIVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLEN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCHHHHHHH
LFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVIDYKTELQEVLQIGGETTISYK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEE
ILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
EECCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKLQKKLKNDYGLVFNDEYLLKTAFTHSSFTNEERLPKIANNERLEFLGDVALSLVISD
CCCHHHHHCCCCCEEECCCHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
YLYRTYPEKLEGELSKMRSSIVRTESLANFSRSCGFGEFLRLGHGEEKMGGRDRETTLEN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCHHHHHHH
LFEAFLGALFIDQGMDEVRKFIQHVVIPHVKNDDYVKVIDYKTELQEVLQIGGETTISYK
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEE
ILKEEGPAHDRSFVAAVFNNGKELGRGLGKSKKVAEQKAAENAIKGQNHVS
EECCCCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]