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The map label for this gene is mutY [H]

Identifier: 125624510

GI number: 125624510

Start: 1691590

End: 1692750

Strand: Reverse

Name: mutY [H]

Synonym: llmg_1717

Alternate gene names: 125624510

Gene position: 1692750-1691590 (Counterclockwise)

Preceding gene: 125624511

Following gene: 125624507

Centisome position: 66.92

GC content: 34.88

Gene sequence:

>1161_bases
ATGGACTGGTCTAAAAATAAAATAAAAGAATTTCAAAAAGATTTACTTTCTTGGTATGATGCTAATAAAAAACCATTACC
TTGGCGACAAACGACCGAACCTTATAAAATCTGGATTTCAGAAATTATGTCGCAGCAAACGCAAGTGGAAACGGTCATAC
CTTATTTTGAACGCTTCATGAAAAAGTACCCTACAGTTGAATCATTAGCTCAAGCTGATGATACAGAGTTATTAAAACTT
TGGGAAGGTTTGGGTTATTATTCACGAGCTCGAAACTTAAAAATTGCAGCACAAGAGGTCGTGAACGAATATAATGGAAA
ATTTCCAGATAATTTGAAAGAGATTCTATCCCTCAGAGGAATTGGTCCTTATACAGCAGCGGCTATTGCATCTATTTCCT
TTGATTTGGCTGAACCAGCTATCGATGGAAATTTGATGCGCGTGACAAGTAGAATTTTTGAATTAGAGTGTGATATTTCA
AAAAGTAGTTCACGAAAAATATTTGATGAGCATTTACGGACACTCGTCAGTAAAAAAAGACCTGGTGATTTTAATCAAGG
ACTGATGGATTTAGGTTCACTTGTGTGTAGCCCAAAGAAGCCAAAATGTGAAACCTGTCCGCTGAATAAATACTGTGGGG
CAGTAGCTGATGGAAAACAATTGAACTATCCAGTAAAAACAAAAAAGCTCAAACAAAAAGAGTTGTATTATACTGCCTTC
GCATTAGAGAATTCTCTAGGTGAATACTATTTGGAGAAACGACCATCGAAAGGCTTGTTAGCTGATATGTGGACCTTTCC
ACTGACAGAATTATCATCAGTAGACTTTGAAAAAATAATTACTGACGGAGCAATCAGTAAAAATATTACCATGCCAGAAC
TTCCTGAAAGTATATCTAAGATGGAATACTTCGGTAATTTCACTCATATCTTTTCTCATCAAAAATGGCACATTGTACTT
ATCAAAGTAAAGGCAGAAGAGAAGTTTGAAATTGCTGATGAATTACTGACAGCTGATAAAAAATGGGTTTATTATGATTC
AAAAAAATTAGGCGAAAATGTTGTCAATCTAAATCAGGATTTATCAAAGATAAGCCGTTTAAAGCTTCCACTTTCTGGTC
CGCAAGTGAAAATGTTTGAACTCTTAGATAAAAAAATATGA

Upstream 100 bases:

>100_bases
TAAGCAAAAGGATTGTCAGTAAAAACTGTCAGTTCTTTTATCTTGTCAGTAAAACAAAGAAGAGTGCTTGAAGCATATCG
AAAATGTAAATGGAGAATTG

Downstream 100 bases:

>100_bases
AAACTATTGTAAAACTCTATTGGTTCACACTGTAAATTAAATAATAAAAAAAACATTGGCAACGCGAACCAATGTTTTTT
TGTGTTGGAGTAAAATAATA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MDWSKNKIKEFQKDLLSWYDANKKPLPWRQTTEPYKIWISEIMSQQTQVETVIPYFERFMKKYPTVESLAQADDTELLKL
WEGLGYYSRARNLKIAAQEVVNEYNGKFPDNLKEILSLRGIGPYTAAAIASISFDLAEPAIDGNLMRVTSRIFELECDIS
KSSSRKIFDEHLRTLVSKKRPGDFNQGLMDLGSLVCSPKKPKCETCPLNKYCGAVADGKQLNYPVKTKKLKQKELYYTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELSSVDFEKIITDGAISKNITMPELPESISKMEYFGNFTHIFSHQKWHIVL
IKVKAEEKFEIADELLTADKKWVYYDSKKLGENVVNLNQDLSKISRLKLPLSGPQVKMFELLDKKI

Sequences:

>Translated_386_residues
MDWSKNKIKEFQKDLLSWYDANKKPLPWRQTTEPYKIWISEIMSQQTQVETVIPYFERFMKKYPTVESLAQADDTELLKL
WEGLGYYSRARNLKIAAQEVVNEYNGKFPDNLKEILSLRGIGPYTAAAIASISFDLAEPAIDGNLMRVTSRIFELECDIS
KSSSRKIFDEHLRTLVSKKRPGDFNQGLMDLGSLVCSPKKPKCETCPLNKYCGAVADGKQLNYPVKTKKLKQKELYYTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELSSVDFEKIITDGAISKNITMPELPESISKMEYFGNFTHIFSHQKWHIVL
IKVKAEEKFEIADELLTADKKWVYYDSKKLGENVVNLNQDLSKISRLKLPLSGPQVKMFELLDKKI
>Mature_386_residues
MDWSKNKIKEFQKDLLSWYDANKKPLPWRQTTEPYKIWISEIMSQQTQVETVIPYFERFMKKYPTVESLAQADDTELLKL
WEGLGYYSRARNLKIAAQEVVNEYNGKFPDNLKEILSLRGIGPYTAAAIASISFDLAEPAIDGNLMRVTSRIFELECDIS
KSSSRKIFDEHLRTLVSKKRPGDFNQGLMDLGSLVCSPKKPKCETCPLNKYCGAVADGKQLNYPVKTKKLKQKELYYTAF
ALENSLGEYYLEKRPSKGLLADMWTFPLTELSSVDFEKIITDGAISKNITMPELPESISKMEYFGNFTHIFSHQKWHIVL
IKVKAEEKFEIADELLTADKKWVYYDSKKLGENVVNLNQDLSKISRLKLPLSGPQVKMFELLDKKI

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=366, Percent_Identity=34.4262295081967, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298650, Length=366, Percent_Identity=34.4262295081967, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298654, Length=366, Percent_Identity=34.4262295081967, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298652, Length=366, Percent_Identity=34.4262295081967, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI190358497, Length=366, Percent_Identity=34.4262295081967, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI6912520, Length=366, Percent_Identity=34.4262295081967, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4505471, Length=204, Percent_Identity=25.9803921568627, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1789331, Length=268, Percent_Identity=42.5373134328358, Blast_Score=217, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 44468; Mature: 44468

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWSKNKIKEFQKDLLSWYDANKKPLPWRQTTEPYKIWISEIMSQQTQVETVIPYFERFM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPTVESLAQADDTELLKLWEGLGYYSRARNLKIAAQEVVNEYNGKFPDNLKEILSLRG
HHCCCHHHHHCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
IGPYTAAAIASISFDLAEPAIDGNLMRVTSRIFELECDISKSSSRKIFDEHLRTLVSKKR
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
PGDFNQGLMDLGSLVCSPKKPKCETCPLNKYCGAVADGKQLNYPVKTKKLKQKELYYTAF
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALENSLGEYYLEKRPSKGLLADMWTFPLTELSSVDFEKIITDGAISKNITMPELPESISK
HHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHH
MEYFGNFTHIFSHQKWHIVLIKVKAEEKFEIADELLTADKKWVYYDSKKLGENVVNLNQD
HHHHCCHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LSKISRLKLPLSGPQVKMFELLDKKI
HHHHHHHCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDWSKNKIKEFQKDLLSWYDANKKPLPWRQTTEPYKIWISEIMSQQTQVETVIPYFERFM
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYPTVESLAQADDTELLKLWEGLGYYSRARNLKIAAQEVVNEYNGKFPDNLKEILSLRG
HHCCCHHHHHCCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
IGPYTAAAIASISFDLAEPAIDGNLMRVTSRIFELECDISKSSSRKIFDEHLRTLVSKKR
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
PGDFNQGLMDLGSLVCSPKKPKCETCPLNKYCGAVADGKQLNYPVKTKKLKQKELYYTAF
CCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
ALENSLGEYYLEKRPSKGLLADMWTFPLTELSSVDFEKIITDGAISKNITMPELPESISK
HHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHH
MEYFGNFTHIFSHQKWHIVLIKVKAEEKFEIADELLTADKKWVYYDSKKLGENVVNLNQD
HHHHCCHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHH
LSKISRLKLPLSGPQVKMFELLDKKI
HHHHHHHCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]