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The map label for this gene is uvrC

Identifier: 125624511

GI number: 125624511

Start: 1692848

End: 1694857

Strand: Reverse

Name: uvrC

Synonym: llmg_1718

Alternate gene names: 125624511

Gene position: 1694857-1692848 (Counterclockwise)

Preceding gene: 125624512

Following gene: 125624510

Centisome position: 67.0

GC content: 36.32

Gene sequence:

>2010_bases
ATGAATCAAACGATAAAAGCGAAGTTGGAGCTATTGCCTGATAGCCCTGGCTGTTATTTACATAAAGATAAAAATGGGAC
TGTTATTTATGTCGGAAAGGCAAAGAATCTGAAAAACCGAGTGCGCTCTTATTTTCATGGTTCTCATAATACAAAGACAG
AATTATTGGTTTCCGAAATTGAAGATTTGGAATGGATTGTTGTAGGTTCTAATATTGAATCTCTGGTCTTAGAAATAAAT
CTTATTCAACGTTACAAGCCAAAATATAATATCATGCTTAAGGATGATAAATATTACCCTTTTTTGAAAATAACAAATGA
AAAATATCCTCGCCTGTTAGTTGTACGTAAAGTTCAAAAAGATGGGGCGACTTATTTTGGACCTTATCCAGATGTTAAGG
CTGCTAATGAAGTTAAACGACTTTTAGACCGAATTTTTCCTTTTAGAAAGTGCGGATTGCACGAGAAAAAAGTCTGCTTC
TATTTTCATATCCATCAGTGTTTATGTCCGGTTGTTAATCACGTTGACCCACAAGTATATAAGGACATGACTCAAGAAGT
CAAAGAGTTTCTAACAGGTTCAGATAAAAAAATTGTTAAAGAACTTGAAGGAAAAATGATAAGTGCTTCAGATAATATGG
AATTTGAGCAAGCTGCCGAATATCGTGATGTGATTAAGGCGATTGGAACCTTAAGAACGAAACAGCGGGTGATGAATCAG
GATTTGAAAGACCGAGATGTATTTGGCTATTACGTTGATAAAGGATGGATGTGTGTTCAGGTCTTTTTCGTGCGTCAAGG
GAAACTGATTCAACGAGATGTTAATATGTTTCCATATTACAATGATGCCGAAGAAGATTTCTTGACTTATATTGGTCAGT
TTTATCAAGATAATAATCATATGATGCCAAGAGAGATTTTTATTCCTCAAGATATTGATAAGGATTCTGTAGAAGCAGTA
GTTGCCGCCAGTCAAGAAGGAAATTTGCTGACAAAAGCGCAAGCTAAAGCAGTAGATGCTAAAGTCTTTACGGCAAAAAC
GCTTAAATTTTCTGACCAAAAAGATGTTGAGCAATCAATTGTCAAACTAGATAAAGAATTATCATCAGAGAAACGTTTGT
CTTCACTTTTAGCTAAAACACAGATTATCCAACCAAGTCGTGGAGAGAAAAAACAATTGGTTAATATGGCGACCAAGAAT
GCTCAGACTCAATTACAGCTGAAATTCGATGTGGCTGAACGTGACATTTTAAAAACTACTAAAGCAGTTGAAAATTTAGG
GAAAATTTTAGGAATACCAAAACCGGTTAGAATTGAGTCTTTTGATAATTCAAATATCATGGGAACTTCACCAGTGTCTG
CGATGGTCGTATTTATTGATGGAAAACCGTCAAAAAAAGATTATCGGAAGTATAAAATTAAAACAGTAGTTGGAGCTGAC
GATTACGCCTCAATGCGCGAAGTGATGACCAGACGTTATTCGCGAGCGCTCAAAGAAGAAACTGCTCTTCCTGATTTGAT
TGCAATGGATGGGGGGGCAGGTCAAGTTAATATTGCCAAAGAAGTTTTGCGAGAACTTGGTTTAGCTATTCCTGTAGCGG
GGATGCAAAAAAATGATAAGCACCAAACATCAGAGTTACTTTTTGGTGATCCACTAGAGGTTGTCCCCCTATCAAGACAA
TCTCAAGAATTCTTTTTACTGACCAGAATTCAAGATGAAGTTCACCGCTTTGCGATTACCTTTCATAGACAACTACGTGG
GAAAAATACATTTTCAAGTAAGTTGGATGGAATTGTTGGATTAGGACCAAAACGGAAGCAAAAATTGCTGACAACTTTTA
AAAATTTAAAAGCGATTGAAGAAGCGACAGTTCAAGAAGTTGCTGAGGCAGGAGTTCCTTATGAAGTTGCCGAGCGTGTC
AAAAACACTTTGTCTGCTCCTCATAAAAGCGATGAAAATTGGGAATCCATCAAAGATAATGTTCCTCTTTTAAAAAGTGA
AAAGTCATAA

Upstream 100 bases:

>100_bases
AATGATTAGTCAAAATACCCTAAGGATTTAGGGTGTTTTTTGTTCTTATTAACATCCAAAAGGAGAGCAGCTCCTACATT
TTTTTGCTATAATAAACATT

Downstream 100 bases:

>100_bases
GCAAAAGGATTGTCAGTAAAAACTGTCAGTTCTTTTATCTTGTCAGTAAAACAAAGAAGAGTGCTTGAAGCATATCGAAA
ATGTAAATGGAGAATTGATG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVYKDMTQEVKEFLTGSDKKIVKELEGKMISASDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKDSVEAV
VAASQEGNLLTKAQAKAVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSSEKRLSSLLAKTQIIQPSRGEKKQLVNMATKN
AQTQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNIAKEVLRELGLAIPVAGMQKNDKHQTSELLFGDPLEVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEATVQEVAEAGVPYEVAERV
KNTLSAPHKSDENWESIKDNVPLLKSEKS

Sequences:

>Translated_669_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVYKDMTQEVKEFLTGSDKKIVKELEGKMISASDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKDSVEAV
VAASQEGNLLTKAQAKAVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSSEKRLSSLLAKTQIIQPSRGEKKQLVNMATKN
AQTQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNIAKEVLRELGLAIPVAGMQKNDKHQTSELLFGDPLEVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEATVQEVAEAGVPYEVAERV
KNTLSAPHKSDENWESIKDNVPLLKSEKS
>Mature_669_residues
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDLEWIVVGSNIESLVLEIN
LIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQKDGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCF
YFHIHQCLCPVVNHVDPQVYKDMTQEVKEFLTGSDKKIVKELEGKMISASDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNHMMPREIFIPQDIDKDSVEAV
VAASQEGNLLTKAQAKAVDAKVFTAKTLKFSDQKDVEQSIVKLDKELSSEKRLSSLLAKTQIIQPSRGEKKQLVNMATKN
AQTQLQLKFDVAERDILKTTKAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNIAKEVLRELGLAIPVAGMQKNDKHQTSELLFGDPLEVVPLSRQ
SQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVGLGPKRKQKLLTTFKNLKAIEEATVQEVAEAGVPYEVAERV
KNTLSAPHKSDENWESIKDNVPLLKSEKS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=656, Percent_Identity=32.1646341463415, Blast_Score=313, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_LACLM (A2RLW6)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032994.1
- ProteinModelPortal:   A2RLW6
- STRING:   A2RLW6
- GeneID:   4796774
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1718
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 76434; Mature: 76434

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEI
CCCCEEEHEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
EDLEWIVVGSNIESLVLEINLIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQK
CCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCFYFHIHQCLCPVVNHVDPQVY
CCCEECCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHH
KDMTQEVKEFLTGSDKKIVKELEGKMISASDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNH
CCCCCCEEEEEECCCEEEEEEEHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
MMPREIFIPQDIDKDSVEAVVAASQEGNLLTKAQAKAVDAKVFTAKTLKFSDQKDVEQSI
CCCCEEECCCCCCHHHHHHHEEECCCCCEEEHHHHHHHHHHEEEEEEECCCCHHHHHHHH
VKLDKELSSEKRLSSLLAKTQIIQPSRGEKKQLVNMATKNAQTQLQLKFDVAERDILKTT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHH
KAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEEECCC
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNIAKEVLRELGLAIPVAGMQKNDK
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCC
HQTSELLFGDPLEVVPLSRQSQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVG
HHHHHHHCCCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEC
LGPKRKQKLLTTFKNLKAIEEATVQEVAEAGVPYEVAERVKNTLSAPHKSDENWESIKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
VPLLKSEKS
CCCCCCCCC
>Mature Secondary Structure
MNQTIKAKLELLPDSPGCYLHKDKNGTVIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEI
CCCCEEEHEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
EDLEWIVVGSNIESLVLEINLIQRYKPKYNIMLKDDKYYPFLKITNEKYPRLLVVRKVQK
CCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DGATYFGPYPDVKAANEVKRLLDRIFPFRKCGLHEKKVCFYFHIHQCLCPVVNHVDPQVY
CCCEECCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEHHHHHHHHHHCCCHHHH
KDMTQEVKEFLTGSDKKIVKELEGKMISASDNMEFEQAAEYRDVIKAIGTLRTKQRVMNQ
HHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DLKDRDVFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYIGQFYQDNNH
CCCCCCEEEEEECCCEEEEEEEHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
MMPREIFIPQDIDKDSVEAVVAASQEGNLLTKAQAKAVDAKVFTAKTLKFSDQKDVEQSI
CCCCEEECCCCCCHHHHHHHEEECCCCCEEEHHHHHHHHHHEEEEEEECCCCHHHHHHHH
VKLDKELSSEKRLSSLLAKTQIIQPSRGEKKQLVNMATKNAQTQLQLKFDVAERDILKTT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHH
KAVENLGKILGIPKPVRIESFDNSNIMGTSPVSAMVVFIDGKPSKKDYRKYKIKTVVGAD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCCCCHHHEEEEEEEECCC
DYASMREVMTRRYSRALKEETALPDLIAMDGGAGQVNIAKEVLRELGLAIPVAGMQKNDK
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCC
HQTSELLFGDPLEVVPLSRQSQEFFLLTRIQDEVHRFAITFHRQLRGKNTFSSKLDGIVG
HHHHHHHCCCCCCEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEC
LGPKRKQKLLTTFKNLKAIEEATVQEVAEAGVPYEVAERVKNTLSAPHKSDENWESIKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
VPLLKSEKS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA