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The map label for this gene is pacA [H]

Identifier: 125624234

GI number: 125624234

Start: 1389794

End: 1390711

Strand: Reverse

Name: pacA [H]

Synonym: llmg_1422

Alternate gene names: 125624234

Gene position: 1390711-1389794 (Counterclockwise)

Preceding gene: 125624235

Following gene: 125624233

Centisome position: 54.98

GC content: 37.91

Gene sequence:

>918_bases
ATGTGTACTAGTTTTCAACTAAAATCAAGTGATGGTGGCCTAGTTTTTGCAAGAACAATGGATTGGCATCCATTTAAGGC
AGAAGCACTGGTTCTGCCTAAAAATTATGAATGGACAAGTGTTTACAATGGGAAAAAAATGACAAATCCTTATGCAATTC
TTGGTGTTGGGAACAGTGAAATGCGTCTACATGCTGATATTTCTGACGGGGTCAATGAATATGGCTTGGCAGCTCAAAAA
TTAACCTTTTCGAATCAGTCAGATTATGCTAGCGAAGGAGAAGCTGGGAAAATTCAACTCGCTGCTTTTGAATTTTTACT
TTGGTTATTAGGAAACTGTCGTTCAATTGAAGACGTTCGTCAGAAGATTGATACTGTCCAATTAATGACCGATGAAAATT
CAACTTTCAAATTTGGTCGAAATGATTTGCATTTTTCGGCAACGGATTCGAGTGGTCAAATGATAAATATCGAACCACAT
GGTGGACGTCTGATCATTTCAAATAACTCGATAGGTGTGGTCACCAATGCTCCCAAATTTGAAAGAGAAGTTGAAAAATT
AACCACTTATATGGATCTTAATATACTGACAGAACCATCAGTAAAAAATAATAATCCCAATCAGATTTCGACTGGGAGTT
TTAATGGTAAGCCAGTATTTCCTGGTGGATTTACACTGACTTCCCGATTTATCCGGGCCGCTGTCTATAAAGAAAGAGCC
ATTTATCCTAAAAATGAACAGCAAAATATTATTGAAGCTTGGCATATTTTAAATGGGGTGACTGTTCCTAAATCAGAGGG
CCGCTCAGGGACTTATACTGTCTATCGAAGTGCAGTTGAGGTGACGAGTCGAAGACTTTATTTACAGACTTATGAGGATT
TAAACGTTCAAGTCTATCGTTTCCCAGAAGAACTCTAG

Upstream 100 bases:

>100_bases
AACTTTTGTCATAGGATAGCATTTTACAGATATGCTAGTATCTCTATTAGTAAATTTTTTGATAAAATAAATAGATGACA
TCTATTTAAGGGGAGAAAAA

Downstream 100 bases:

>100_bases
TCCCAAAATTTTGCTATAATAAAGCAAGATTAATAGGAGAAATTAATGCATTTTATTGTTATATTAGGGGCGCTCATTTC
CTTGTCCTTTACAAGCACTT

Product: penicillin acylase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MCTSFQLKSSDGGLVFARTMDWHPFKAEALVLPKNYEWTSVYNGKKMTNPYAILGVGNSEMRLHADISDGVNEYGLAAQK
LTFSNQSDYASEGEAGKIQLAAFEFLLWLLGNCRSIEDVRQKIDTVQLMTDENSTFKFGRNDLHFSATDSSGQMINIEPH
GGRLIISNNSIGVVTNAPKFEREVEKLTTYMDLNILTEPSVKNNNPNQISTGSFNGKPVFPGGFTLTSRFIRAAVYKERA
IYPKNEQQNIIEAWHILNGVTVPKSEGRSGTYTVYRSAVEVTSRRLYLQTYEDLNVQVYRFPEEL

Sequences:

>Translated_305_residues
MCTSFQLKSSDGGLVFARTMDWHPFKAEALVLPKNYEWTSVYNGKKMTNPYAILGVGNSEMRLHADISDGVNEYGLAAQK
LTFSNQSDYASEGEAGKIQLAAFEFLLWLLGNCRSIEDVRQKIDTVQLMTDENSTFKFGRNDLHFSATDSSGQMINIEPH
GGRLIISNNSIGVVTNAPKFEREVEKLTTYMDLNILTEPSVKNNNPNQISTGSFNGKPVFPGGFTLTSRFIRAAVYKERA
IYPKNEQQNIIEAWHILNGVTVPKSEGRSGTYTVYRSAVEVTSRRLYLQTYEDLNVQVYRFPEEL
>Mature_305_residues
MCTSFQLKSSDGGLVFARTMDWHPFKAEALVLPKNYEWTSVYNGKKMTNPYAILGVGNSEMRLHADISDGVNEYGLAAQK
LTFSNQSDYASEGEAGKIQLAAFEFLLWLLGNCRSIEDVRQKIDTVQLMTDENSTFKFGRNDLHFSATDSSGQMINIEPH
GGRLIISNNSIGVVTNAPKFEREVEKLTTYMDLNILTEPSVKNNNPNQISTGSFNGKPVFPGGFTLTSRFIRAAVYKERA
IYPKNEQQNIIEAWHILNGVTVPKSEGRSGTYTVYRSAVEVTSRRLYLQTYEDLNVQVYRFPEEL

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 34328; Mature: 34328

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTSFQLKSSDGGLVFARTMDWHPFKAEALVLPKNYEWTSVYNGKKMTNPYAILGVGNSE
CCCCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEECCCC
MRLHADISDGVNEYGLAAQKLTFSNQSDYASEGEAGKIQLAAFEFLLWLLGNCRSIEDVR
EEEEECHHCCCHHHCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHH
QKIDTVQLMTDENSTFKFGRNDLHFSATDSSGQMINIEPHGGRLIISNNSIGVVTNAPKF
HHHCEEEEEECCCCEEEECCCCEEEEEECCCCCEEEEECCCCEEEEECCCEEEEECCCHH
EREVEKLTTYMDLNILTEPSVKNNNPNQISTGSFNGKPVFPGGFTLTSRFIRAAVYKERA
HHHHHHHHHHEEEEEEECCCCCCCCCCEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHC
IYPKNEQQNIIEAWHILNGVTVPKSEGRSGTYTVYRSAVEVTSRRLYLQTYEDLNVQVYR
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHEEEEEEECCCCEEEEE
FPEEL
CCCCC
>Mature Secondary Structure
MCTSFQLKSSDGGLVFARTMDWHPFKAEALVLPKNYEWTSVYNGKKMTNPYAILGVGNSE
CCCCEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEECCCC
MRLHADISDGVNEYGLAAQKLTFSNQSDYASEGEAGKIQLAAFEFLLWLLGNCRSIEDVR
EEEEECHHCCCHHHCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHH
QKIDTVQLMTDENSTFKFGRNDLHFSATDSSGQMINIEPHGGRLIISNNSIGVVTNAPKF
HHHCEEEEEECCCCEEEECCCCEEEEEECCCCCEEEEECCCCEEEEECCCEEEEECCCHH
EREVEKLTTYMDLNILTEPSVKNNNPNQISTGSFNGKPVFPGGFTLTSRFIRAAVYKERA
HHHHHHHHHHEEEEEEECCCCCCCCCCEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHC
IYPKNEQQNIIEAWHILNGVTVPKSEGRSGTYTVYRSAVEVTSRRLYLQTYEDLNVQVYR
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHEEEEEEECCCCEEEEE
FPEEL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]