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The map label for this gene is tpiA [H]

Identifier: 125624235

GI number: 125624235

Start: 1390877

End: 1391635

Strand: Reverse

Name: tpiA [H]

Synonym: llmg_1424

Alternate gene names: 125624235

Gene position: 1391635-1390877 (Counterclockwise)

Preceding gene: 125624236

Following gene: 125624234

Centisome position: 55.02

GC content: 41.37

Gene sequence:

>759_bases
ATGTCACGTAAACCAATTATCGCTGGTAACTGGAAAATGAATAAAACTTTGTCAGAAGCACAAGCTTTTGTTGAAGCTGT
TAAAAATAACTTGCCTTCATCTGATAATGTTGAATCAGTTATCGGTGCACCTGCTCTTTTCCTCGCTCCTATGGCTTACC
TTCGTCAAGGTTCAGAATTGAAACTTGCTGCTGAAAATAGCTACTTCGAAAATGCTGGAGCATTCACTGGTGAAAACAGC
CCAGCTGCAATCGTTGACCTTGGTATTGAATACATCATCATCGGTCACAGCGAACGTCGTGAATATTTCCACGAAACTGA
CGAAGACATCAACAAAAAAGCAAAAGCAATCTTCGCTGCTGGAGCAACTCCAATCCTTTGTTGTGGTGAAACTTTGGAAA
CTTTTGAAGCTGGTAAAACAGCTGAATGGGTTTCAGGTCAAATCGAAGCTGGTCTTGCAGGATTGACTGCTGAACAAGTT
TCAAACTTAGTTATCGCTTACGAACCAATCTGGGCAATCGGAACTGGTAAAACTGCGACAAACGAAATTGCTGACGAAAC
TTGTGGTGTTGTACGTTCAACAGTTGAAAAACTTTACGGAAAAGAAGTTTCAGAAGCTGTACGTATCCAATACGGTGGAT
CAGTAAAACCTGAAACAATCGAAGGATTGATGGCTAAAGAAAACATCGACGGTGCCCTCGTTGGTGGAGCTTCACTTGAA
GCTGATAGCTTCCTTGCATTGCTTGAAATGTACAAATAA

Upstream 100 bases:

>100_bases
TCTGCAATTTTTTTCACAATGTGATAAAATAGACCATGTAAAAGATGGATTAAAAGTCCAAAATTTAAGAGGCTTAAAAG
GCCCTATAAGGAGAATTAGA

Downstream 100 bases:

>100_bases
TTTTTAAATTATGGGTTGAATGAAAGTACTGACAGTTCTGTCAGTACTTTTTTCGAGCTTTTTTGAACTTTTGTCATAGG
ATAGCATTTTACAGATATGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSELKLAAENSYFENAGAFTGENS
PAAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAAGATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQV
SNLVIAYEPIWAIGTGKTATNEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLE
ADSFLALLEMYK

Sequences:

>Translated_252_residues
MSRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSELKLAAENSYFENAGAFTGENS
PAAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAAGATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQV
SNLVIAYEPIWAIGTGKTATNEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLE
ADSFLALLEMYK
>Mature_251_residues
SRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSELKLAAENSYFENAGAFTGENSP
AAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAAGATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQVS
NLVIAYEPIWAIGTGKTATNEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLEA
DSFLALLEMYK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=244, Percent_Identity=39.344262295082, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI226529917, Length=244, Percent_Identity=39.344262295082, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=42.5101214574899, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17536593, Length=243, Percent_Identity=43.2098765432099, Blast_Score=170, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6320255, Length=240, Percent_Identity=40.8333333333333, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=45.748987854251, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28572008, Length=245, Percent_Identity=46.1224489795918, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI28572006, Length=245, Percent_Identity=46.1224489795918, Blast_Score=181, Evalue=5e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26934; Mature: 26802

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSEL
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCE
KLAAENSYFENAGAFTGENSPAAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAA
EEEECCCCHHCCCCCCCCCCCEEEEECCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCC
GATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQVSNLVIAYEPIWAIGTGKTAT
CCCCEEECCCHHHHHHCCCCHHHHCCHHHCCHHCCCHHHHCCEEEEECCEEEEECCCCCH
NEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLE
HHHHHHHHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCC
ADSFLALLEMYK
HHHHHHHHHHCC
>Mature Secondary Structure 
SRKPIIAGNWKMNKTLSEAQAFVEAVKNNLPSSDNVESVIGAPALFLAPMAYLRQGSEL
CCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHCCCCCE
KLAAENSYFENAGAFTGENSPAAIVDLGIEYIIIGHSERREYFHETDEDINKKAKAIFAA
EEEECCCCHHCCCCCCCCCCCEEEEECCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHCC
GATPILCCGETLETFEAGKTAEWVSGQIEAGLAGLTAEQVSNLVIAYEPIWAIGTGKTAT
CCCCEEECCCHHHHHHCCCCHHHHCCHHHCCHHCCCHHHHCCEEEEECCEEEEECCCCCH
NEIADETCGVVRSTVEKLYGKEVSEAVRIQYGGSVKPETIEGLMAKENIDGALVGGASLE
HHHHHHHHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCC
ADSFLALLEMYK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7534588; 11337471 [H]