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The map label for this gene is hom [H]

Identifier: 125624152

GI number: 125624152

Start: 1308229

End: 1309515

Strand: Reverse

Name: hom [H]

Synonym: llmg_1332

Alternate gene names: 125624152

Gene position: 1309515-1308229 (Counterclockwise)

Preceding gene: 125624153

Following gene: 125624151

Centisome position: 51.77

GC content: 36.52

Gene sequence:

>1287_bases
ATGGCAGTAAATATAGCAATTTTGGGGTTTGGGACAGTTGGCACAGGGCTTCCAACTTTACTTTCAGAGAATAAAGAGAA
ATTAGCAAAAATATTGGATGAAGAAATCGTCATTTCAAAAGTTTTGATGAGAGATAATAAGGCAATTGAAAAGGCCAGAA
GTCAAGGTTTTAATTATGATTTTGTCTTAAATTTGGACGATATTTTAGCTGATTCAGAAATTTCAATTGTCGTTGAGCTG
ATGGGACGAATTGAACCTGCTAAGACCTACATTACTCAAGCGATAGAAGCAGGTAAAAACGTCGTCACGGCTAACAAAGA
CTTGCTGGCTGTTCATGGGGTGGAACTTCGGAGTTTAGCTCAAAAACATCATGTAGCCCTTTATTATGAAGCGGCAGTCG
CTGGGGGAATTCCTATTTTAAGAACTTTGGCTAATTCATTTTCATCTGATAAAATTACACATCTGTTGGGAATTCTTAAT
GGAACAAGTAATTTTATGATGACGAAAATGAGTGAAGAAGGCTGGACTTATGATGAATCCTTGGCTAAAGCTCAAGAACT
TGGTTATGCTGAATCCGACCCAACAAATGATGTAGACGGAATTGATGCCAGTTATAAATTAGCTATTTTAAGTGAATTTG
CATTTGGAATGACGCTTGCGCCGGATGACATTGCTAAATCTGGTTTGAGAAGTATTCAAAAAACTGATGTCGAGATTGCA
CAACAATTTGGTTATGTTTTAAAGTTGACTGGTGAAATTAACGAAGTTGATTCAGGAATTTTTGCTGAAGTTAGTCCAAC
TTTTCTGCCTAAATCACATCCACTTGCCAGTGTAAATGGGGTCATGAATGCTGTATTCATTGAATCAGAGGGCATTGGAG
ATTCGGTGTTTTATGGTGCAGGAGCGGGTCAAAAACCCACAGCTACGAGTGTTTTAGCAGATATTGTCCGAATTGTTAAA
CGTGTCAAAGATGGGACAATTGGAAAATCATTTAATGAATATGCACGTTCTACAAGTCTAGCTAATCCCCATGATATTGA
AAATAAATATTATTTTTCAGTTGAGACACCTGATTCAACAGGACAGCTTTTGCTCTTGGTTGAGCTATTTACAAGTGAAA
ATGTTTCTTTTGAACAAGTTTTGCAACAAAAAGGAAATGGCAAGCGGGCAGTTGTTGTGATTATTAGTCATAAAATTAAT
CGTGTTCAACTTTCGGCCATTCAAGATAAATTGAATCAAGAAAAAGATTTTAAATTACTTAATCGTTTCAAAGTATTGGG
GGACTAA

Upstream 100 bases:

>100_bases
TAAATTTTTTTCTATAAAAATGGTATAATATTAAGAAATTATTCAAAAGTTATTTTTTGAATTATCTTAACATTTTATTT
TAGATTTTAAAGGAGAACTG

Downstream 100 bases:

>100_bases
TCAAATGAAAATTATTGTGCCAGCAACATCAGCAAATTTAGGTGCCGGTTTTGATTCAATTGGTATCGCCGTCAATTTAT
ATTTGACAGTTGAAGTACTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYDFVLNLDDILADSEISIVVEL
MGRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILN
GTSNFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIA
QQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGAGAGQKPTATSVLADIVRIVK
RVKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDSTGQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKIN
RVQLSAIQDKLNQEKDFKLLNRFKVLGD

Sequences:

>Translated_428_residues
MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYDFVLNLDDILADSEISIVVEL
MGRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILN
GTSNFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIA
QQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGAGAGQKPTATSVLADIVRIVK
RVKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDSTGQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKIN
RVQLSAIQDKLNQEKDFKLLNRFKVLGD
>Mature_427_residues
AVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYDFVLNLDDILADSEISIVVELM
GRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNG
TSNFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIAQ
QFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGAGAGQKPTATSVLADIVRIVKR
VKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDSTGQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKINR
VQLSAIQDKLNQEKDFKLLNRFKVLGD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=29.0836653386454, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46630; Mature: 46499

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00697 DNA_LIGASE_A1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYD
CEEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEE
FVLNLDDILADSEISIVVELMGRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLA
EEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCEEEECCHHHHHHH
QKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTSNFMMTKMSEEGWTYDES
HHCCEEEEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHH
QQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGA
HHCCEEEEEECCCCHHCCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCEEECC
GAGQKPTATSVLADIVRIVKRVKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDST
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
GQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKINRVQLSAIQDKLNQEKDFKLL
CCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHH
NRFKVLGD
HHHHHCCC
>Mature Secondary Structure 
AVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDNKAIEKARSQGFNYD
EEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEE
FVLNLDDILADSEISIVVELMGRIEPAKTYITQAIEAGKNVVTANKDLLAVHGVELRSLA
EEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCEEEECCHHHHHHH
QKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTSNFMMTKMSEEGWTYDES
HHCCEEEEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDDIAKSGLRSIQKTDVEIA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHH
QQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMNAVFIESEGIGDSVFYGA
HHCCEEEEEECCCCHHCCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCEEECC
GAGQKPTATSVLADIVRIVKRVKDGTIGKSFNEYARSTSLANPHDIENKYYFSVETPDST
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
GQLLLLVELFTSENVSFEQVLQQKGNGKRAVVVIISHKINRVQLSAIQDKLNQEKDFKLL
CCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHH
NRFKVLGD
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]