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The map label for this gene is thrB

Identifier: 125624151

GI number: 125624151

Start: 1307334

End: 1308224

Strand: Reverse

Name: thrB

Synonym: llmg_1331

Alternate gene names: 125624151

Gene position: 1308224-1307334 (Counterclockwise)

Preceding gene: 125624152

Following gene: 125624150

Centisome position: 51.72

GC content: 39.17

Gene sequence:

>891_bases
ATGAAAATTATTGTGCCAGCAACATCAGCAAATTTAGGTGCCGGTTTTGATTCAATTGGTATCGCCGTCAATTTATATTT
GACAGTTGAAGTACTTGGGGAAAGTAGGGATTGGAAGATTGACCATGATTTAGGTGAAAATATTCCAACTGACGAAAGAA
ATTTATTACTGACCACACTGTCAGCAGTTTTGGAAGACAAGAATGTCGCTCTGTCAGCAAAATTTCATCTAAAAATGACT
TCAGAAGTCCCTTTGGCAAGAGGACTCGGCTCATCAAGTTCAGTCATTATTGCTGGAATTGAGTTGGCCAATCAGTTGGC
AAAACTTAATTTGACTTCTGATGAAAAACTTAAGTTGGCTTGTGAAATTGAAGGACATCCGGATAATGTCGCTCCAGCTC
TTTTAGGAAATCTGGTTATTGCAAGCACTGTGGCTGGTAAAACAAGTCATATTGTCGCTGATTTTCCTTCATGCGCACTT
TTGGCTTTTGTTCCAGATTATGAATTAAAAACGGTCGAAAGTCGTAAGGTCTTACCCAATGAGTTGACTTATAAAGAAGC
AGTTGCTGCCAGTTCCATTGCGAATGTACTGACAGCCAGTCTTTTGACAAATAATTTAGAAGTAGCAGGGCAAATGATGG
AAGCTGACCGTTTCCATGAAAGCTATCGTGCTTCCTTGATTCCAGAGCTTCAGTTATTGCGAGAAATCGGTCATGAGTTT
GGGGCTTACGGAACTTATCTGAGTGGTGCAGGTCCAACAGTGATGCTGCTTGTACCCGATGATAAGTTAACTTTACTGAC
AGAAAAAATTATGGAAAAAAACCTCACTGGTCACCTTTATCCATTGAAAATTGATAACAAAGGATTACAAGTAGAAGAAT
CTGTATTTTAA

Upstream 100 bases:

>100_bases
AAAATTAATCGTGTTCAACTTTCGGCCATTCAAGATAAATTGAATCAAGAAAAAGATTTTAAATTACTTAATCGTTTCAA
AGTATTGGGGGACTAATCAA

Downstream 100 bases:

>100_bases
TACAGGTTCTTTTTGTTGATTATTTTATAGATAAAATGATATAATCATTAAAGCAAAAAAGAATGTAAAGTAGTTCACTA
ACTTTCGTTTTATTTGTCAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTLSAVLEDKNVALSAKFHLKMT
SEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLACEIEGHPDNVAPALLGNLVIASTVAGKTSHIVADFPSCAL
LAFVPDYELKTVESRKVLPNELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLLREIGHEF
GAYGTYLSGAGPTVMLLVPDDKLTLLTEKIMEKNLTGHLYPLKIDNKGLQVEESVF

Sequences:

>Translated_296_residues
MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTLSAVLEDKNVALSAKFHLKMT
SEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLACEIEGHPDNVAPALLGNLVIASTVAGKTSHIVADFPSCAL
LAFVPDYELKTVESRKVLPNELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLLREIGHEF
GAYGTYLSGAGPTVMLLVPDDKLTLLTEKIMEKNLTGHLYPLKIDNKGLQVEESVF
>Mature_296_residues
MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTLSAVLEDKNVALSAKFHLKMT
SEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLACEIEGHPDNVAPALLGNLVIASTVAGKTSHIVADFPSCAL
LAFVPDYELKTVESRKVLPNELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLLREIGHEF
GAYGTYLSGAGPTVMLLVPDDKLTLLTEKIMEKNLTGHLYPLKIDNKGLQVEESVF

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=314, Percent_Identity=25.1592356687898, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321814, Length=314, Percent_Identity=28.343949044586, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_LACLC (P52991)

Other databases:

- EMBL:   X96988
- PIR:   JC6050
- ProteinModelPortal:   P52991
- SMR:   P52991
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 31893; Mature: 31893

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTL
CEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEECHHHCCCCCCCCCHHHHHHH
SAVLEDKNVALSAKFHLKMTSEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLA
HHHHCCCCEEEEEEEEEEECCCCCHHHCCCCCCCEEEEEHHHHHHHHEECCCCCCCEEEE
CEIEGHPDNVAPALLGNLVIASTVAGKTSHIVADFPSCALLAFVPDYELKTVESRKVLPN
EEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCEEECCCCCCCCC
ELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLLREIGHEF
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
GAYGTYLSGAGPTVMLLVPDDKLTLLTEKIMEKNLTGHLYPLKIDNKGLQVEESVF
CCCCCEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHCCC
>Mature Secondary Structure
MKIIVPATSANLGAGFDSIGIAVNLYLTVEVLGESRDWKIDHDLGENIPTDERNLLLTTL
CEEEEECCCCCCCCCCCCCCEEEEEEEEEEEECCCCCEEECHHHCCCCCCCCCHHHHHHH
SAVLEDKNVALSAKFHLKMTSEVPLARGLGSSSSVIIAGIELANQLAKLNLTSDEKLKLA
HHHHCCCCEEEEEEEEEEECCCCCHHHCCCCCCCEEEEEHHHHHHHHEECCCCCCCEEEE
CEIEGHPDNVAPALLGNLVIASTVAGKTSHIVADFPSCALLAFVPDYELKTVESRKVLPN
EEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCEEECCCCCCCCC
ELTYKEAVAASSIANVLTASLLTNNLEVAGQMMEADRFHESYRASLIPELQLLREIGHEF
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
GAYGTYLSGAGPTVMLLVPDDKLTLLTEKIMEKNLTGHLYPLKIDNKGLQVEESVF
CCCCCEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8682767