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The map label for this gene is hisI [H]

Identifier: 125624111

GI number: 125624111

Start: 1260189

End: 1260827

Strand: Reverse

Name: hisI [H]

Synonym: llmg_1289

Alternate gene names: 125624111

Gene position: 1260827-1260189 (Counterclockwise)

Preceding gene: 125624112

Following gene: 125624110

Centisome position: 49.85

GC content: 36.93

Gene sequence:

>639_bases
ATGAAACCAGATTTTCAAAAGCAGGCGCTCATTCCTGTCATTGTGCAAGATTATCAAACGAAGCAAGTTTTGATGATGGC
TTATACAAACGAGGAGGCCTATCAAAAAATGATTGAAAGTGGCGAAACTTGGTTTTGGTCACGTTCAAGACAAAAACTTT
GGCATAAAGGGGAAGAATCGGGTCATTTTCAAAAAGTAAAAGGAATGCGCTTAGATTGTGACCAGGATACTTTACTTGTT
TTTGTTGAGCAGACTGGTAATGCTTGTCATACAGGTGCCTATTCTTGTTTTTATGACGAAGTCATTCCTTTTGATGACTC
GGATATTTTTGCTGATTTAGAAAAACAAATCGCTGACAGAAAAGCACACCCAGTAGAGAAATCATATACAAATTATTTGC
TTGATCAAGGAGTTGACAAGGTTTTAAAGAAAGTTGGTGAAGAGGCCAGTGAAGTAATTATCGCTAGTAAAAATTTGGAT
AAGACTGAACTCTTGGGTGAAATTGATGATTTGCTTTATCATTTGTTTGTTCTGATGAATCAAACTGATCTTTCTCTTGA
AGAAGTGCGGAAAAAAGCGCGTGAGCGTCATCAGATTGAAGGAAATAAAAAGGAATTTCACACAAGGACGGCAGATTAA

Upstream 100 bases:

>100_bases
TTGCTTCTTTATTTCATTATGGAGAAGCAACAGTGGATGAAGTTAAAGAAGAACTCATAAAAAATCGTATTCCAGCAAGA
ATAATTAAGAAGGAGATTAT

Downstream 100 bases:

>100_bases
ATGAAAAAATTAGATTATCATTTGCATTCTTATTTTTCGGCTGACAGTGAGGAAAATCCCAGAAATCATGTCTTAGAAGC
GATTGAGCATGGTTTGGAGG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKPDFQKQALIPVIVQDYQTKQVLMMAYTNEEAYQKMIESGETWFWSRSRQKLWHKGEESGHFQKVKGMRLDCDQDTLLV
FVEQTGNACHTGAYSCFYDEVIPFDDSDIFADLEKQIADRKAHPVEKSYTNYLLDQGVDKVLKKVGEEASEVIIASKNLD
KTELLGEIDDLLYHLFVLMNQTDLSLEEVRKKARERHQIEGNKKEFHTRTAD

Sequences:

>Translated_212_residues
MKPDFQKQALIPVIVQDYQTKQVLMMAYTNEEAYQKMIESGETWFWSRSRQKLWHKGEESGHFQKVKGMRLDCDQDTLLV
FVEQTGNACHTGAYSCFYDEVIPFDDSDIFADLEKQIADRKAHPVEKSYTNYLLDQGVDKVLKKVGEEASEVIIASKNLD
KTELLGEIDDLLYHLFVLMNQTDLSLEEVRKKARERHQIEGNKKEFHTRTAD
>Mature_212_residues
MKPDFQKQALIPVIVQDYQTKQVLMMAYTNEEAYQKMIESGETWFWSRSRQKLWHKGEESGHFQKVKGMRLDCDQDTLLV
FVEQTGNACHTGAYSCFYDEVIPFDDSDIFADLEKQIADRKAHPVEKSYTNYLLDQGVDKVLKKVGEEASEVIIASKNLD
KTELLGEIDDLLYHLFVLMNQTDLSLEEVRKKARERHQIEGNKKEFHTRTAD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=190, Percent_Identity=43.1578947368421, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319819, Length=182, Percent_Identity=32.967032967033, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24673; Mature: 24673

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDFQKQALIPVIVQDYQTKQVLMMAYTNEEAYQKMIESGETWFWSRSRQKLWHKGEES
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEHHHHHHHHHCCCCC
GHFQKVKGMRLDCDQDTLLVFVEQTGNACHTGAYSCFYDEVIPFDDSDIFADLEKQIADR
CCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHC
KAHPVEKSYTNYLLDQGVDKVLKKVGEEASEVIIASKNLDKTELLGEIDDLLYHLFVLMN
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
QTDLSLEEVRKKARERHQIEGNKKEFHTRTAD
CCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure
MKPDFQKQALIPVIVQDYQTKQVLMMAYTNEEAYQKMIESGETWFWSRSRQKLWHKGEES
CCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHCCCCEEEHHHHHHHHHCCCCC
GHFQKVKGMRLDCDQDTLLVFVEQTGNACHTGAYSCFYDEVIPFDDSDIFADLEKQIADR
CCHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHC
KAHPVEKSYTNYLLDQGVDKVLKKVGEEASEVIIASKNLDKTELLGEIDDLLYHLFVLMN
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
QTDLSLEEVRKKARERHQIEGNKKEFHTRTAD
CCCCCHHHHHHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400209; 11337471 [H]