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The map label for this gene is arsA [H]

Identifier: 125624073

GI number: 125624073

Start: 1218639

End: 1220354

Strand: Direct

Name: arsA [H]

Synonym: llmg_1248

Alternate gene names: 125624073

Gene position: 1218639-1220354 (Clockwise)

Preceding gene: 125624072

Following gene: 125624074

Centisome position: 48.18

GC content: 35.9

Gene sequence:

>1716_bases
ATGAAAGCTTACGATCCAAAAAAATTAGAATTGACTAAATATCTGTTCTTTACAGGAAAAGGTGGGGTTGGCAAAACAAC
GTCTGCATGTGCAACTGCAGTAAGTCTTGCGGATTCAGGTTATAAAGTAATACTTGTCAGTACTGACCCTGCTTCTAATT
TACAAGATGTATTTCAAACAGAATTAACCAATAAACCAAAAGAAATTCCAGAAATTCCTAATTTAAAAGTCGCAAATTTT
GACCCAGTATCTGCGGCAAATGATCATAAAGAAAGTATAGTTGGTCCATATCGAGGAATTTTACCAGACTCAGCTATAGA
AAATATGGAAGAACAACTTTCAGGTTCATGTACCGTTGAAATTGCTTCTTTTAATGAATTTGCTGGTTTCTTAACAAATA
AGGATGTCAAAGATGAATTTGACTATGTCATTTTTGATACCGCACCAACCGGACATACCCTCAGAATGCTTGCTCTTCCT
TCCGCATGGTCTAACTACCTGGATGAAAATGATACTGGTGTTTCGTGCTTAGGTCAACTTTCAGGACTGGGAGATAAAAA
GGAAAGTTACGAACGAGCAGTAAAAACATTAGCTAACGGTGAATTAACAACGCTTATGTTAGTAACACGTCCTCAAAAAG
CATCAATTGAGGAAGCCAAAAGAGCTTCTGGTGAACTTGCGGAACTCGGAATAAATAATCAAAAATTAATTATTAATGGA
CTTTTAACTCAAGCAGATGATGAAGTATCAAAGATTATTGCCAAACAACAAGAAGATGATTTAGAGCATTTGCCTAACTT
TCTCAGTAAGTATGAACAATTCTTTATTCCACTCAGACCCTATAATGTGACTGGGTTAGATAAAATTCGCATCCTTTTAG
ATACAGTTCAACCCGAATTGCCTGAGATTGATTCAGAAATGAGAGAATATCCAGAACTCTCAACTGTGATTGATAATTTT
GTCAAAACAGGTAAAAAAATTATCTTTACAATGGGTAAAGGTGGAGTTGGAAAAACTACTGTAGCGATTAAAGTTGCTCA
AGCTTTGCAAAAGCAAGGTAAAAAAGTTCATCTGGCTACTACAGACCCTGCGGACCATCTTAATTTCTACTTGGGAGATA
CTTCTGGACTCTCATTAAGTCATATTGATGAAGAAAAGGAACTTCGAGAATATAAAGAAGAAGTTTTAAGCAAAGCAAGA
GAAACAATGTCAGGCGATGATTTTGACTATGTTAAAGAAGACTTGGAATCACCATGTACGCAAGAAATTGCAGTCTTTCG
TGCTTTCGCTGAAATTGTTGAAAAAGCAGACGATGAGATTGTAGTAATTGATACTGCGCCAACTGGTCATACCCTCTTAT
TACTTGAATCAACTCAAAGCTATGCGAAAGAAGTTGAACGGACAAGTGGTGAAGTTCCAAAATCAATTCAAAAACTTTTA
CCAAGATTACAAAACTCTGATGAAACAGAAGTTTTGATGGTGACTTTACCAGAAGCCACTCCAGTTTATGAATCAATGCG
ATTAGCAGATGATTTAGATAGAGCAAATATTGCATATACTTGGTGGTTAGTAAACCAAAGTATGAGTGCAACTCATACCT
CGAATGAAGTTTTGAAAGCACGTGCATCAAATGAAGTAGAATGGATTAATAAAGTTGCCAAACTTTCTAATCAACACTAT
GCAGTAGCTAAATGGCAAGCTGACTTTGAAAAATAA

Upstream 100 bases:

>100_bases
AAAAGGAGCTTGTTGCTCAAATTCCCAAGAAGAAGTCAAAGTAGAGGCTAATACCACATGTTGTGGTGGAAATACTGGTT
GCTGTTAATAGGGAGAAATG

Downstream 100 bases:

>100_bases
AGGAAATGATTATCCTATGAAAATTATTATAATTGGTTCTGTAGCTTCAGGAACAAGTGTTGCTGCTAAGGCACGTAGAA
ATACAGAGAGTGCAGAGATA

Product: arsenical pump-driving ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKAYDPKKLELTKYLFFTGKGGVGKTTSACATAVSLADSGYKVILVSTDPASNLQDVFQTELTNKPKEIPEIPNLKVANF
DPVSAANDHKESIVGPYRGILPDSAIENMEEQLSGSCTVEIASFNEFAGFLTNKDVKDEFDYVIFDTAPTGHTLRMLALP
SAWSNYLDENDTGVSCLGQLSGLGDKKESYERAVKTLANGELTTLMLVTRPQKASIEEAKRASGELAELGINNQKLIING
LLTQADDEVSKIIAKQQEDDLEHLPNFLSKYEQFFIPLRPYNVTGLDKIRILLDTVQPELPEIDSEMREYPELSTVIDNF
VKTGKKIIFTMGKGGVGKTTVAIKVAQALQKQGKKVHLATTDPADHLNFYLGDTSGLSLSHIDEEKELREYKEEVLSKAR
ETMSGDDFDYVKEDLESPCTQEIAVFRAFAEIVEKADDEIVVIDTAPTGHTLLLLESTQSYAKEVERTSGEVPKSIQKLL
PRLQNSDETEVLMVTLPEATPVYESMRLADDLDRANIAYTWWLVNQSMSATHTSNEVLKARASNEVEWINKVAKLSNQHY
AVAKWQADFEK

Sequences:

>Translated_571_residues
MKAYDPKKLELTKYLFFTGKGGVGKTTSACATAVSLADSGYKVILVSTDPASNLQDVFQTELTNKPKEIPEIPNLKVANF
DPVSAANDHKESIVGPYRGILPDSAIENMEEQLSGSCTVEIASFNEFAGFLTNKDVKDEFDYVIFDTAPTGHTLRMLALP
SAWSNYLDENDTGVSCLGQLSGLGDKKESYERAVKTLANGELTTLMLVTRPQKASIEEAKRASGELAELGINNQKLIING
LLTQADDEVSKIIAKQQEDDLEHLPNFLSKYEQFFIPLRPYNVTGLDKIRILLDTVQPELPEIDSEMREYPELSTVIDNF
VKTGKKIIFTMGKGGVGKTTVAIKVAQALQKQGKKVHLATTDPADHLNFYLGDTSGLSLSHIDEEKELREYKEEVLSKAR
ETMSGDDFDYVKEDLESPCTQEIAVFRAFAEIVEKADDEIVVIDTAPTGHTLLLLESTQSYAKEVERTSGEVPKSIQKLL
PRLQNSDETEVLMVTLPEATPVYESMRLADDLDRANIAYTWWLVNQSMSATHTSNEVLKARASNEVEWINKVAKLSNQHY
AVAKWQADFEK
>Mature_571_residues
MKAYDPKKLELTKYLFFTGKGGVGKTTSACATAVSLADSGYKVILVSTDPASNLQDVFQTELTNKPKEIPEIPNLKVANF
DPVSAANDHKESIVGPYRGILPDSAIENMEEQLSGSCTVEIASFNEFAGFLTNKDVKDEFDYVIFDTAPTGHTLRMLALP
SAWSNYLDENDTGVSCLGQLSGLGDKKESYERAVKTLANGELTTLMLVTRPQKASIEEAKRASGELAELGINNQKLIING
LLTQADDEVSKIIAKQQEDDLEHLPNFLSKYEQFFIPLRPYNVTGLDKIRILLDTVQPELPEIDSEMREYPELSTVIDNF
VKTGKKIIFTMGKGGVGKTTVAIKVAQALQKQGKKVHLATTDPADHLNFYLGDTSGLSLSHIDEEKELREYKEEVLSKAR
ETMSGDDFDYVKEDLESPCTQEIAVFRAFAEIVEKADDEIVVIDTAPTGHTLLLLESTQSYAKEVERTSGEVPKSIQKLL
PRLQNSDETEVLMVTLPEATPVYESMRLADDLDRANIAYTWWLVNQSMSATHTSNEVLKARASNEVEWINKVAKLSNQHY
AVAKWQADFEK

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=323, Percent_Identity=28.4829721362229, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17557003, Length=316, Percent_Identity=30.6962025316456, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320103, Length=309, Percent_Identity=29.4498381877023, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24586297, Length=305, Percent_Identity=28.1967213114754, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 63397; Mature: 63397

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYDPKKLELTKYLFFTGKGGVGKTTSACATAVSLADSGYKVILVSTDPASNLQDVFQT
CCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ELTNKPKEIPEIPNLKVANFDPVSAANDHKESIVGPYRGILPDSAIENMEEQLSGSCTVE
HHCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCHHCCCCCHHHHHHHHHCCCCEEEE
IASFNEFAGFLTNKDVKDEFDYVIFDTAPTGHTLRMLALPSAWSNYLDENDTGVSCLGQL
EECCHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHCCCCCCCHHHHHHH
SGLGDKKESYERAVKTLANGELTTLMLVTRPQKASIEEAKRASGELAELGINNQKLIING
HCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCHHHCCCCCCEEEEEE
LLTQADDEVSKIIAKQQEDDLEHLPNFLSKYEQFFIPLRPYNVTGLDKIRILLDTVQPEL
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCC
PEIDSEMREYPELSTVIDNFVKTGKKIIFTMGKGGVGKTTVAIKVAQALQKQGKKVHLAT
CHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEE
TDPADHLNFYLGDTSGLSLSHIDEEKELREYKEEVLSKARETMSGDDFDYVKEDLESPCT
CCCHHHCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHH
QEIAVFRAFAEIVEKADDEIVVIDTAPTGHTLLLLESTQSYAKEVERTSGEVPKSIQKLL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHH
PRLQNSDETEVLMVTLPEATPVYESMRLADDLDRANIAYTWWLVNQSMSATHTSNEVLKA
HHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHH
RASNEVEWINKVAKLSNQHYAVAKWQADFEK
HCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKAYDPKKLELTKYLFFTGKGGVGKTTSACATAVSLADSGYKVILVSTDPASNLQDVFQT
CCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH
ELTNKPKEIPEIPNLKVANFDPVSAANDHKESIVGPYRGILPDSAIENMEEQLSGSCTVE
HHCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCHHCCCCCHHHHHHHHHCCCCEEEE
IASFNEFAGFLTNKDVKDEFDYVIFDTAPTGHTLRMLALPSAWSNYLDENDTGVSCLGQL
EECCHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHCCCCCCCHHHHHHH
SGLGDKKESYERAVKTLANGELTTLMLVTRPQKASIEEAKRASGELAELGINNQKLIING
HCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHCCCCHHHCCCCCCEEEEEE
LLTQADDEVSKIIAKQQEDDLEHLPNFLSKYEQFFIPLRPYNVTGLDKIRILLDTVQPEL
HHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCC
PEIDSEMREYPELSTVIDNFVKTGKKIIFTMGKGGVGKTTVAIKVAQALQKQGKKVHLAT
CHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEE
TDPADHLNFYLGDTSGLSLSHIDEEKELREYKEEVLSKARETMSGDDFDYVKEDLESPCT
CCCHHHCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHH
QEIAVFRAFAEIVEKADDEIVVIDTAPTGHTLLLLESTQSYAKEVERTSGEVPKSIQKLL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHH
PRLQNSDETEVLMVTLPEATPVYESMRLADDLDRANIAYTWWLVNQSMSATHTSNEVLKA
HHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHH
RASNEVEWINKVAKLSNQHYAVAKWQADFEK
HCCCHHHHHHHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9464374 [H]