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The map label for this gene is panE [C]

Identifier: 125623962

GI number: 125623962

Start: 1095546

End: 1096484

Strand: Direct

Name: panE [C]

Synonym: llmg_1131

Alternate gene names: 125623962

Gene position: 1095546-1096484 (Clockwise)

Preceding gene: 125623961

Following gene: 125623963

Centisome position: 43.31

GC content: 35.04

Gene sequence:

>939_bases
ATGAGAATCACAATTGCCGGTGCAGGAGCGATGGGAAGCCGTTTTGGGCTTATGCTTCATAGAGGGGGCAACGAAGTGAC
CCTTGTAGATGGTTGGCTTGAACATGTGACTGCAATTAAAGAACACGGCCTACAAGCAAATTTTAATGGTGAAGAAATCA
CTGCTCATCTATCAGTAGAATTACAATCTAATATTTCATCAGAAGAAAAAACAGATTTAATTATTTTATTTACGAAAGCA
ATGCAGTTAGATAAAATGCTTCAGGACATTAAACCTTTAATTGCTGAGCATACAAAAGTTCTTTGCTTACTTAATGGGAT
TGGTCATGAAGATATTATTGAAAAATATGTTTCTAAAAATAATATTTTTATTGGGAATACCATGTGGACTGCAGGTTTAG
AAGGACCAGGAAAAGCAAAACTATTTGGAAATGGTTCTGTTGAACTTCAAAATTTCATTCCTGGCGAAGAAGAAACGGCT
AAAAAATTAGCTGACATTTTATCTGCTTCAGGATTAAATGCTAACTATTCTGATAACATCCATTATTCAATTTACCGAAA
AGCGTGCGTTAATGGGACAATGAATGGACTCTGCACTATTTTGGATACTAATATGGCTGGATTGGGAGCAACAAAACCTG
CTCACGATATGGTTGTTACAATTGTCAAAGAATTTGCGGCAGTTGCAAAACATGAGGATGTGAATCTTGATATAGATGAG
GTCGTAGAACATGTTGAGACATGTTTTGACCCTGAAACTATTGGCTTACATTATCCTTCAATGTATCAAGATTTGATAAA
TAATAATCGCTTGACAGAGATAGATTATATTAATGGTGCAGTTTCACGTAAAGGGAAAAAATATCAGATAGCTACTCCTT
ACTGTGACTTTTTGACTCAATTAGTTCATAGTAAAGAAGAGTTATTAAAGGCGAAATAA

Upstream 100 bases:

>100_bases
TATAAATAATTTGTTATCTATAAATTACTAAACTGAACTCGTTTTAAAATTACGAATTCAGTTATTTTATAGGGAAAAAT
ATATAGATTGAGAGAATAAA

Downstream 100 bases:

>100_bases
AATAATTTTAGTTTCTGAAAAAGGCTAGTTTATAATTAGCCTTTTTTGTTTTCTTTAGGGATGAGGATAACAATCTGGTA
GCAAACAAACTAAAGTTTTT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRITIAGAGAMGSRFGLMLHRGGNEVTLVDGWLEHVTAIKEHGLQANFNGEEITAHLSVELQSNISSEEKTDLIILFTKA
MQLDKMLQDIKPLIAEHTKVLCLLNGIGHEDIIEKYVSKNNIFIGNTMWTAGLEGPGKAKLFGNGSVELQNFIPGEEETA
KKLADILSASGLNANYSDNIHYSIYRKACVNGTMNGLCTILDTNMAGLGATKPAHDMVVTIVKEFAAVAKHEDVNLDIDE
VVEHVETCFDPETIGLHYPSMYQDLINNNRLTEIDYINGAVSRKGKKYQIATPYCDFLTQLVHSKEELLKAK

Sequences:

>Translated_312_residues
MRITIAGAGAMGSRFGLMLHRGGNEVTLVDGWLEHVTAIKEHGLQANFNGEEITAHLSVELQSNISSEEKTDLIILFTKA
MQLDKMLQDIKPLIAEHTKVLCLLNGIGHEDIIEKYVSKNNIFIGNTMWTAGLEGPGKAKLFGNGSVELQNFIPGEEETA
KKLADILSASGLNANYSDNIHYSIYRKACVNGTMNGLCTILDTNMAGLGATKPAHDMVVTIVKEFAAVAKHEDVNLDIDE
VVEHVETCFDPETIGLHYPSMYQDLINNNRLTEIDYINGAVSRKGKKYQIATPYCDFLTQLVHSKEELLKAK
>Mature_312_residues
MRITIAGAGAMGSRFGLMLHRGGNEVTLVDGWLEHVTAIKEHGLQANFNGEEITAHLSVELQSNISSEEKTDLIILFTKA
MQLDKMLQDIKPLIAEHTKVLCLLNGIGHEDIIEKYVSKNNIFIGNTMWTAGLEGPGKAKLFGNGSVELQNFIPGEEETA
KKLADILSASGLNANYSDNIHYSIYRKACVNGTMNGLCTILDTNMAGLGATKPAHDMVVTIVKEFAAVAKHEDVNLDIDE
VVEHVETCFDPETIGLHYPSMYQDLINNNRLTEIDYINGAVSRKGKKYQIATPYCDFLTQLVHSKEELLKAK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=318, Percent_Identity=27.3584905660377, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34363; Mature: 34363

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITIAGAGAMGSRFGLMLHRGGNEVTLVDGWLEHVTAIKEHGLQANFNGEEITAHLSVE
CEEEEEECCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
LQSNISSEEKTDLIILFTKAMQLDKMLQDIKPLIAEHTKVLCLLNGIGHEDIIEKYVSKN
EECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCC
NIFIGNTMWTAGLEGPGKAKLFGNGSVELQNFIPGEEETAKKLADILSASGLNANYSDNI
CEEEECCEEECCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
HYSIYRKACVNGTMNGLCTILDTNMAGLGATKPAHDMVVTIVKEFAAVAKHEDVNLDIDE
EEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
VVEHVETCFDPETIGLHYPSMYQDLINNNRLTEIDYINGAVSRKGKKYQIATPYCDFLTQ
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEECHHHHHHHH
LVHSKEELLKAK
HHHCHHHHHCCC
>Mature Secondary Structure
MRITIAGAGAMGSRFGLMLHRGGNEVTLVDGWLEHVTAIKEHGLQANFNGEEITAHLSVE
CEEEEEECCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEE
LQSNISSEEKTDLIILFTKAMQLDKMLQDIKPLIAEHTKVLCLLNGIGHEDIIEKYVSKN
EECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCC
NIFIGNTMWTAGLEGPGKAKLFGNGSVELQNFIPGEEETAKKLADILSASGLNANYSDNI
CEEEECCEEECCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCE
HYSIYRKACVNGTMNGLCTILDTNMAGLGATKPAHDMVVTIVKEFAAVAKHEDVNLDIDE
EEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
VVEHVETCFDPETIGLHYPSMYQDLINNNRLTEIDYINGAVSRKGKKYQIATPYCDFLTQ
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEECHHHHHHHH
LVHSKEELLKAK
HHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]