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The map label for this gene is trpC

Identifier: 125623871

GI number: 125623871

Start: 999809

End: 1000603

Strand: Direct

Name: trpC

Synonym: llmg_1038

Alternate gene names: 125623871

Gene position: 999809-1000603 (Clockwise)

Preceding gene: 125623870

Following gene: 125623872

Centisome position: 39.53

GC content: 33.08

Gene sequence:

>795_bases
ATGAACATAAAAGAAGGAAAATTCTTAGAAACAATTTTAGCAGAAAAAAAACAAGAGATAGCTCAAATGCCTGACGAAAA
TTCCAAACCAATTCGTCAAACTTATAGATTATATGATTACCTAAAAAAACATTCTGATCAACTTCAAGTCATTGCCGAAG
TAAAAAAAGCTTCGCCAAGTCTTGGAGATATCAATCTCGAAGTAGACATTATCGCCCAAGCCAAAAATTATGAACAAGCT
GGGGCTGCCATGATTTCCGTTCTAACTGACCCTGTATTCTTTAAAGGAAACATTGAATACCTCCGTGAAATATCTAAGAA
TGTTCAAATTCCAACACTTAACAAAGATTTTATCATTGATAAAAAGCAAATTAATCGAGCACTCAATGCTGGTGCAACTG
TTATTTTATTGATTGTCGCTTGTTTTGAAAATGACTTTGAAAAATTAGAAGAACTCTACAATTATGCAATTTCACTAGGA
CTTGAAGTTTTAGTCGAAACGCATAATAAGGCCGAACTCGACAGAGCCCATCAACTTGCTGCTAAAATTATTGGGGTCAA
TAATCGTAATCTAAAGACCTTCGAAGTGAGCTTACAAAACTCAACAGATTTGGTTCCTTATTTTAAAGAAGAGAATGTTT
ATATTTCTGAATCAGGTATTTTCGGTAAAAAAGAGGCACAAAAAGTTGCTGAAAATTTCAATGGAATTTTGGTTGGAACA
GCACTGATGCAAGCAAATAATCTCACAAAATCACTGACAGATTTAAAAATCAAAAGGAAAAATGATGAACATTAA

Upstream 100 bases:

>100_bases
TCGTCCCTCTGATCAAAAATATTACTACGCGGCATTCATCATTGACCCAGACGGTTATCGAATTGAAGCAGTCTGTTACA
CTGGAAAAGAGTAAGAAAAT

Downstream 100 bases:

>100_bases
AATTTGTGGCTTATCAACAAAAGAGGCTGTCGATACGGCAGTAGCATCTGGCGCAACACATCTTGGTTTTATTCTTAGTC
CCTCAAGGCGTCAAGTTTCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPSLGDINLEVDIIAQAKNYEQA
GAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIIDKKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLG
LEVLVETHNKAELDRAHQLAAKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGT
ALMQANNLTKSLTDLKIKRKNDEH

Sequences:

>Translated_264_residues
MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPSLGDINLEVDIIAQAKNYEQA
GAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIIDKKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLG
LEVLVETHNKAELDRAHQLAAKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGT
ALMQANNLTKSLTDLKIKRKNDEH
>Mature_264_residues
MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPSLGDINLEVDIIAQAKNYEQA
GAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIIDKKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLG
LEVLVETHNKAELDRAHQLAAKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGT
ALMQANNLTKSLTDLKIKRKNDEH

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=241, Percent_Identity=34.8547717842324, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322638, Length=228, Percent_Identity=39.4736842105263, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LACLM (A2RK21)

Other databases:

- EMBL:   AM406671
- RefSeq:   YP_001032354.1
- ProteinModelPortal:   A2RK21
- SMR:   A2RK21
- STRING:   A2RK21
- GeneID:   4798085
- GenomeReviews:   AM406671_GR
- KEGG:   llm:llmg_1038
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   KRASPRG
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29862; Mature: 29862

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPS
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
LGDINLEVDIIAQAKNYEQAGAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCCCCCCEEC
KKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLGLEVLVETHNKAELDRAHQLA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGT
HHHHCCCCCCEEEEEEEECCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHCCCCEEEHH
ALMQANNLTKSLTDLKIKRKNDEH
HHHHHHHHHHHHHHHEEECCCCCC
>Mature Secondary Structure
MNIKEGKFLETILAEKKQEIAQMPDENSKPIRQTYRLYDYLKKHSDQLQVIAEVKKASPS
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
LGDINLEVDIIAQAKNYEQAGAAMISVLTDPVFFKGNIEYLREISKNVQIPTLNKDFIID
CCCEEEEEEEEECCCCCHHHHHHHHHHHHCCEEECCCHHHHHHHHHCCCCCCCCCCCEEC
KKQINRALNAGATVILLIVACFENDFEKLEELYNYAISLGLEVLVETHNKAELDRAHQLA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AKIIGVNNRNLKTFEVSLQNSTDLVPYFKEENVYISESGIFGKKEAQKVAENFNGILVGT
HHHHCCCCCCEEEEEEEECCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHCCCCEEEHH
ALMQANNLTKSLTDLKIKRKNDEH
HHHHHHHHHHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA