Click here to switch to the map view.

The map label for this gene is trpF [H]

Identifier: 125623872

GI number: 125623872

Start: 1000593

End: 1001651

Strand: Direct

Name: trpF [H]

Synonym: llmg_1039

Alternate gene names: 125623872

Gene position: 1000593-1001651 (Clockwise)

Preceding gene: 125623871

Following gene: 125623873

Centisome position: 39.56

GC content: 35.88

Gene sequence:

>1059_bases
ATGAACATTAAAATTTGTGGCTTATCAACAAAAGAGGCTGTCGATACGGCAGTAGCATCTGGCGCAACACATCTTGGTTT
TATTCTTAGTCCCTCAAGGCGTCAAGTTTCTCCAGAAAAAGTAGCAGAGCTGACAAAGGAAATCCCCATAACAGTCAAAA
AAGTAGGAATCTTTGTTAATGAATCCCTTGATTTTGTCAAAAAAGCCATACAGATTGCCCAGTTGGACATTGTCCAACTT
CACGGCGACGAGGATATGAATTATATCAATCAGCTGTCATTTCCTGTCATTAAAGCTGTACGTCCTGACCAAGATTTTCG
GCTCTACAAAGAGGTCATATTATTATTTGATAGCCCACAAGGAGGAAGTGGTCAAACTTTTGATTGGGATTCCATAAACC
ATGAGCATCTTGGTGCTGATTACTTTATTGCTGGTGGACTCAGTCCAGAGAACGTAGGAAGAGCGATTCAACACTTTCCT
AATGCTTTTGGGGTAGACGTATCCTCAGGAGTGGAGACTGCTGGGAAAAAAGATGTAGTTAAAATAAAAAGTTTTATTCA
AAAGGTGAGTCTTGCTTCATCACAACAATTATTTGCGGAATTTTTACGAATTACTGGAAAATTAAATAAGTTTAAGATTA
GTCCTTATTTAATGGGGAGCTTAGCAATTGAACAACTTGGAAATTTTTTTACAAATCCAGACGATATCGATATTCAGCTA
GAGAAAGATGACTATGAAAATTTTGCTAAATTAACCGAGATAATGGAAGACTTAGGCTATCAACTCATTGACCTACACGA
ACATAAATTTGAAAAAGGAAGATTTCATGTTGGCTTTGCAAATGTTGAAACAATCGATAGTTATGCGAATATTGATTATC
ATGAACTTCAACAAAATAAGCAAGTAACTAAGGAAAGATACTGGTTTCCAAATCTTGAACAATCAATTAAAATCTATCAA
ACAGCAATAAAAGATTCATGGCGAGCCGGAAAACTCAAAGACCAAGTTATCCTAAACAAACTGATTGATTATCAAAAAAG
GAACAATAATGAAAGATGA

Upstream 100 bases:

>100_bases
GTTGCTGAAAATTTCAATGGAATTTTGGTTGGAACAGCACTGATGCAAGCAAATAATCTCACAAAATCACTGACAGATTT
AAAAATCAAAAGGAAAAATG

Downstream 100 bases:

>100_bases
CAGACAAAAGAATTCTTTTGAATACTACCGAAAAGCTGGAACAGATTTGATTCTGAGGACCATTCAAAAAGGAGATTTAT
TAGAACTTTGGGAAGTCAGC

Product: N-(5'-phosphoribosyl)-anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNIKICGLSTKEAVDTAVASGATHLGFILSPSRRQVSPEKVAELTKEIPITVKKVGIFVNESLDFVKKAIQIAQLDIVQL
HGDEDMNYINQLSFPVIKAVRPDQDFRLYKEVILLFDSPQGGSGQTFDWDSINHEHLGADYFIAGGLSPENVGRAIQHFP
NAFGVDVSSGVETAGKKDVVKIKSFIQKVSLASSQQLFAEFLRITGKLNKFKISPYLMGSLAIEQLGNFFTNPDDIDIQL
EKDDYENFAKLTEIMEDLGYQLIDLHEHKFEKGRFHVGFANVETIDSYANIDYHELQQNKQVTKERYWFPNLEQSIKIYQ
TAIKDSWRAGKLKDQVILNKLIDYQKRNNNER

Sequences:

>Translated_352_residues
MNIKICGLSTKEAVDTAVASGATHLGFILSPSRRQVSPEKVAELTKEIPITVKKVGIFVNESLDFVKKAIQIAQLDIVQL
HGDEDMNYINQLSFPVIKAVRPDQDFRLYKEVILLFDSPQGGSGQTFDWDSINHEHLGADYFIAGGLSPENVGRAIQHFP
NAFGVDVSSGVETAGKKDVVKIKSFIQKVSLASSQQLFAEFLRITGKLNKFKISPYLMGSLAIEQLGNFFTNPDDIDIQL
EKDDYENFAKLTEIMEDLGYQLIDLHEHKFEKGRFHVGFANVETIDSYANIDYHELQQNKQVTKERYWFPNLEQSIKIYQ
TAIKDSWRAGKLKDQVILNKLIDYQKRNNNER
>Mature_352_residues
MNIKICGLSTKEAVDTAVASGATHLGFILSPSRRQVSPEKVAELTKEIPITVKKVGIFVNESLDFVKKAIQIAQLDIVQL
HGDEDMNYINQLSFPVIKAVRPDQDFRLYKEVILLFDSPQGGSGQTFDWDSINHEHLGADYFIAGGLSPENVGRAIQHFP
NAFGVDVSSGVETAGKKDVVKIKSFIQKVSLASSQQLFAEFLRITGKLNKFKISPYLMGSLAIEQLGNFFTNPDDIDIQL
EKDDYENFAKLTEIMEDLGYQLIDLHEHKFEKGRFHVGFANVETIDSYANIDYHELQQNKQVTKERYWFPNLEQSIKIYQ
TAIKDSWRAGKLKDQVILNKLIDYQKRNNNER

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ynaI in the C-terminal section [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=200, Percent_Identity=34, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320210, Length=210, Percent_Identity=37.6190476190476, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 39951; Mature: 39951

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKICGLSTKEAVDTAVASGATHLGFILSPSRRQVSPEKVAELTKEIPITVKKVGIFVN
CCEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEEEEEEC
ESLDFVKKAIQIAQLDIVQLHGDEDMNYINQLSFPVIKAVRPDQDFRLYKEVILLFDSPQ
CHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCC
GGSGQTFDWDSINHEHLGADYFIAGGLSPENVGRAIQHFPNAFGVDVSSGVETAGKKDVV
CCCCCCCCCCCCCHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KIKSFIQKVSLASSQQLFAEFLRITGKLNKFKISPYLMGSLAIEQLGNFFTNPDDIDIQL
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEE
EKDDYENFAKLTEIMEDLGYQLIDLHEHKFEKGRFHVGFANVETIDSYANIDYHELQQNK
CCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHHHH
QVTKERYWFPNLEQSIKIYQTAIKDSWRAGKLKDQVILNKLIDYQKRNNNER
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIKICGLSTKEAVDTAVASGATHLGFILSPSRRQVSPEKVAELTKEIPITVKKVGIFVN
CCEEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEEEEEEEC
ESLDFVKKAIQIAQLDIVQLHGDEDMNYINQLSFPVIKAVRPDQDFRLYKEVILLFDSPQ
CHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCC
GGSGQTFDWDSINHEHLGADYFIAGGLSPENVGRAIQHFPNAFGVDVSSGVETAGKKDVV
CCCCCCCCCCCCCHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KIKSFIQKVSLASSQQLFAEFLRITGKLNKFKISPYLMGSLAIEQLGNFFTNPDDIDIQL
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEE
EKDDYENFAKLTEIMEDLGYQLIDLHEHKFEKGRFHVGFANVETIDSYANIDYHELQQNK
CCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCEEEEECCHHHHHHHHCCCHHHHHHHH
QVTKERYWFPNLEQSIKIYQTAIKDSWRAGKLKDQVILNKLIDYQKRNNNER
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400208; 11337471 [H]