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The map label for this gene is purK [H]

Identifier: 125623837

GI number: 125623837

Start: 966149

End: 967255

Strand: Direct

Name: purK [H]

Synonym: llmg_1000

Alternate gene names: 125623837

Gene position: 966149-967255 (Clockwise)

Preceding gene: 125623836

Following gene: 125623839

Centisome position: 38.2

GC content: 37.67

Gene sequence:

>1107_bases
GTGATAAAGAATACAAAGCAAACGATTGGAATCATTGGTGGAGGTCAGCTTGGACAGATGATGGCAATTGCCGCTCAATA
TATGGGGCATAAGGTGATTACTCTGGACCCTAATCCAAATTGCTCAGCGGCAAAAGTATCTGATGAACTCATTGTTGCTC
CTTATGATGATGTAGAAAATTTATTGCGACTTGCCTATGCTTGCGATGTTATTACTTATGAGTTTGAAAATGTTTCAGCA
GAAGCACTACATGAGATTGAAGCTTGCGTCAAGATTCCTCAAGGAATTCGTTTGCTAGAGATTACACAAAACCGACGCTT
TGAAAAGGAATTTTTGACAAATGAAGCAAAAGTCAAAGTTGCTCCATGGCAATTGATTGATTCAAAAGAAAAACTTCCGC
AAGTCGTCACTAAAAAACAAGTTTTGAAGACGACGACGGGAGGTTATGATGGACATGGACAAGTAGTTTTAAAGACGGAC
AAAGACTTGTCAGCTGCTCAATCACTGACAGAAATTTCCGAATGTGTTTTAGAAGATTTTATTTCCTTTGACCGTGAAAT
TTCAGTCATTATTAGTGGAAATGGTCATGAGTATGTTACTTTTCCTTTGGCCGAAAATGAGCACCGCGAAAATATTTTAC
ATCAGACGATTTCACCAGCTCGTGTGACTGACAAAATCACTGACGAAGCTAATAAAATTGCGAAATCAATTGCAGAGAAA
TTGAAACTTTCTGGAACGCTTTGTGTTGAGATGTTTTTAACAGCTGACGGTCAAATCTATGTCAATGAACTTGCGCCAAG
ACCGCATAATAGTGGTCATTTTACCATTGAAGCCTGTGATTTCAATCAATTTGACTTGCATATCAAAGGAATTTTAGGAG
AAGATTTACCGGAACCCAAACTCTTAAATGCTGCTATTATGTTAAATGTTTTAGGACAACATGTGGAAGCCGTTAAGGTG
CTCAATCATAATCATGCGGATTGGCATCAACATGATTACGGAAAGCCTGATGCTAAACATAACCGAAAGATGGGACATGT
GACTATCTTAACGAATGATTTTGACAAAACAATTAATGAAATTAAAGCCACAAAAATTTGGGATTAA

Upstream 100 bases:

>100_bases
GCCGCTCAAGAAATGGTTGAGCAATCAAACAATGAATTGAAATGATTTAATAAAAATACAAAAGCGGTTAGATTTCTAAA
AATGAAGGGTAGGAAAACTT

Downstream 100 bases:

>100_bases
AAAATACTTGATTAATATCAAGTATTTTTTTATTTACTTTGGATAGGGTAAAATGACAACATTTCCCCTAAAAAAAAGAA
CAAATCAGTAAGATAAACTC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAKVSDELIVAPYDDVENLLRLAYACDVITYEFENVSA
EALHEIEACVKIPQGIRLLEITQNRRFEKEFLTNEAKVKVAPWQLIDSKEKLPQVVTKKQVLKTTTGGYDGHGQVVLKTD
KDLSAAQSLTEISECVLEDFISFDREISVIISGNGHEYVTFPLAENEHRENILHQTISPARVTDKITDEANKIAKSIAEK
LKLSGTLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDFNQFDLHIKGILGEDLPEPKLLNAAIMLNVLGQHVEAVKV
LNHNHADWHQHDYGKPDAKHNRKMGHVTILTNDFDKTINEIKATKIWD

Sequences:

>Translated_368_residues
MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAKVSDELIVAPYDDVENLLRLAYACDVITYEFENVSA
EALHEIEACVKIPQGIRLLEITQNRRFEKEFLTNEAKVKVAPWQLIDSKEKLPQVVTKKQVLKTTTGGYDGHGQVVLKTD
KDLSAAQSLTEISECVLEDFISFDREISVIISGNGHEYVTFPLAENEHRENILHQTISPARVTDKITDEANKIAKSIAEK
LKLSGTLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDFNQFDLHIKGILGEDLPEPKLLNAAIMLNVLGQHVEAVKV
LNHNHADWHQHDYGKPDAKHNRKMGHVTILTNDFDKTINEIKATKIWD
>Mature_368_residues
MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAKVSDELIVAPYDDVENLLRLAYACDVITYEFENVSA
EALHEIEACVKIPQGIRLLEITQNRRFEKEFLTNEAKVKVAPWQLIDSKEKLPQVVTKKQVLKTTTGGYDGHGQVVLKTD
KDLSAAQSLTEISECVLEDFISFDREISVIISGNGHEYVTFPLAENEHRENILHQTISPARVTDKITDEANKIAKSIAEK
LKLSGTLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDFNQFDLHIKGILGEDLPEPKLLNAAIMLNVLGQHVEAVKV
LNHNHADWHQHDYGKPDAKHNRKMGHVTILTNDFDKTINEIKATKIWD

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=369, Percent_Identity=27.3712737127371, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788155, Length=371, Percent_Identity=23.4501347708895, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=374, Percent_Identity=32.620320855615, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41093; Mature: 41093

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAKVSDELIVAPYDDVEN
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEECCCCEEEECHHHHHH
LLRLAYACDVITYEFENVSAEALHEIEACVKIPQGIRLLEITQNRRFEKEFLTNEAKVKV
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCEEEE
APWQLIDSKEKLPQVVTKKQVLKTTTGGYDGHGQVVLKTDKDLSAAQSLTEISECVLEDF
CCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
ISFDREISVIISGNGHEYVTFPLAENEHRENILHQTISPARVTDKITDEANKIAKSIAEK
HCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LKLSGTLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDFNQFDLHIKGILGEDLPEPK
HHCCCCEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCH
LLNAAIMLNVLGQHVEAVKVLNHNHADWHQHDYGKPDAKHNRKMGHVTILTNDFDKTINE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHH
IKATKIWD
HHHHCCCC
>Mature Secondary Structure
MIKNTKQTIGIIGGGQLGQMMAIAAQYMGHKVITLDPNPNCSAAKVSDELIVAPYDDVEN
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCEECCCCEEEECHHHHHH
LLRLAYACDVITYEFENVSAEALHEIEACVKIPQGIRLLEITQNRRFEKEFLTNEAKVKV
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCEEEE
APWQLIDSKEKLPQVVTKKQVLKTTTGGYDGHGQVVLKTDKDLSAAQSLTEISECVLEDF
CCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
ISFDREISVIISGNGHEYVTFPLAENEHRENILHQTISPARVTDKITDEANKIAKSIAEK
HCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LKLSGTLCVEMFLTADGQIYVNELAPRPHNSGHFTIEACDFNQFDLHIKGILGEDLPEPK
HHCCCCEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCCH
LLNAAIMLNVLGQHVEAVKVLNHNHADWHQHDYGKPDAKHNRKMGHVTILTNDFDKTINE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHH
IKATKIWD
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA