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The map label for this gene is adhB [H]

Identifier: 125623794

GI number: 125623794

Start: 921340

End: 922386

Strand: Direct

Name: adhB [H]

Synonym: llmg_0955

Alternate gene names: 125623794

Gene position: 921340-922386 (Clockwise)

Preceding gene: 125623793

Following gene: 125623796

Centisome position: 36.42

GC content: 43.46

Gene sequence:

>1047_bases
ATGAGGTCAGCCTATTTTGTCGAAAAAAATAAGATGGAAGTTAGAGAATTTCCCAAAGCGCAACTTGTAAAAGAAACAGA
TGCCATTATAAAAATCGTTCGTGCCTGCGTTTGTGGTTCTGATTTATGGTGGTTCCGTGGGATTTCTGAACGTCAGCCAG
GTCCAGTAGGTCATGAGGCTATTGGTGTCATTGAAGAAGGTGGAGCGGGAGTTAAAAACTTTAAAGCGGGAGATTTTGTC
ATTGTTCCCTTTACTCATGGTTGTGGACACTGTCCAATCTGTTTGGCAGGATTTGAAGCTAATTGCCCCAATGCTAAAGA
TGGAGTTAACGGGGGATATCAAGGAGAATTCTATCGAGCAATTAATGCTGATGGTGCACTTGTTAAAATTCCAGGAAGAC
CAAGTGATTATTCAGAAGAACAGCTGGCTTCGTTGACAACTTTAGCGGATGTCATGCCCACAGGTTTTCATGCGGCTAAA
GCAGCAGATGTCCACGAAGGCGACACAGTAGTTGTCTTTGGCGATGGAGCAGTAGGTCTGTGCGCAGTGATTTCGGCTAA
ACTTTTAGGTGCAAAACGGATTATTGCAATGAGTCGCCATGAAGATCGAGCGGCATTGGCGCGTGATTTTGGGGCAACAG
ATATCATTGCTGAGCGTGGCGCAGAAGCGATTCAAAAAATTATGGCCATAACCAATGGTTATGGTGCTGATGCTGCCTTA
GAGTGTGTCGGAACAAAAGAAGCCATTGAATCTGCTTTCCAAGCAGTAAGAGCGGGAGGACGTGTAGGTCGCGTGGGAGT
TCCTCATGATGTTGATTACAATGAATGGATTGATTCTCTTTTTTGGAAAAATATTCAACTTGGAGGTGGAGTAGCCTCTG
TCGCACGGTGGGATAAGGAAATCTTACTTGAAGCAGTTTTAAGTGGGGAGATTGATCCAGGGCGTGTCTTTACAGAAGAA
TTTACCCTAGATGAAATTCAAAAGGCATATGAAGCAATGGATCAACGGACAGCAATTAAATCTTTATTGATAATTTCAGA
AGGATAA

Upstream 100 bases:

>100_bases
TTCTTATGCTTTCAAAGCATAAGAAGTTTTTTAAAAAGTATTTTTCAAAAAGCTAAATTCATTTTATAATGAATTCAATA
AATGAAAAGGAAGTAAAAAA

Downstream 100 bases:

>100_bases
ATAAGAAAAATTAAAAAAGTCTACCAAAGCTGGTAGACTTTTTTAATAGATTAGTACTTTAGAAATATTAATAGAAAAGT
CAGAGTTGATTCCTAATTAT

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRSAYFVEKNKMEVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGVIEEGGAGVKNFKAGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINADGALVKIPGRPSDYSEEQLASLTTLADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIAERGAEAIQKIMAITNGYGADAAL
ECVGTKEAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEIDPGRVFTEE
FTLDEIQKAYEAMDQRTAIKSLLIISEG

Sequences:

>Translated_348_residues
MRSAYFVEKNKMEVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGVIEEGGAGVKNFKAGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINADGALVKIPGRPSDYSEEQLASLTTLADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIAERGAEAIQKIMAITNGYGADAAL
ECVGTKEAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEIDPGRVFTEE
FTLDEIQKAYEAMDQRTAIKSLLIISEG
>Mature_348_residues
MRSAYFVEKNKMEVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGVIEEGGAGVKNFKAGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINADGALVKIPGRPSDYSEEQLASLTTLADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIAERGAEAIQKIMAITNGYGADAAL
ECVGTKEAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEIDPGRVFTEE
FTLDEIQKAYEAMDQRTAIKSLLIISEG

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=355, Percent_Identity=27.887323943662, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=27.5956284153005, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=27.8409090909091, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI71743840, Length=358, Percent_Identity=26.536312849162, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI262073058, Length=358, Percent_Identity=26.536312849162, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=23.3128834355828, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786825, Length=385, Percent_Identity=28.3116883116883, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=30.3834808259587, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=29.6969696969697, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=349, Percent_Identity=28.080229226361, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=27.5482093663912, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=27.6276276276276, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081918, Length=273, Percent_Identity=34.0659340659341, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=250, Percent_Identity=28.4, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=368, Percent_Identity=27.1739130434783, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=332, Percent_Identity=23.1927710843373, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=25.6484149855908, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=357, Percent_Identity=26.0504201680672, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=357, Percent_Identity=25.7703081232493, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=347, Percent_Identity=25.6484149855908, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=24.251497005988, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=27.6422764227642, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=343, Percent_Identity=27.1137026239067, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=343, Percent_Identity=27.1137026239067, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=26.1627906976744, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=251, Percent_Identity=27.4900398406374, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=22.4080267558528, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=278, Percent_Identity=27.6978417266187, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=282, Percent_Identity=27.6595744680851, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=299, Percent_Identity=25.752508361204, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=27.3529411764706, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737897, Length=352, Percent_Identity=25, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 37320; Mature: 37320

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSAYFVEKNKMEVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEA
CCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHH
IGVIEEGGAGVKNFKAGDFVIVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRA
HEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
INADGALVKIPGRPSDYSEEQLASLTTLADVMPTGFHAAKAADVHEGDTVVVFGDGAVGL
ECCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECCCHHHH
CAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIAERGAEAIQKIMAITNGYGADAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHE
ECVGTKEAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKE
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEECCCCHHHHHHHHHH
ILLEAVLSGEIDPGRVFTEEFTLDEIQKAYEAMDQRTAIKSLLIISEG
HHHHHHHCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MRSAYFVEKNKMEVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEA
CCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHH
IGVIEEGGAGVKNFKAGDFVIVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRA
HEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
INADGALVKIPGRPSDYSEEQLASLTTLADVMPTGFHAAKAADVHEGDTVVVFGDGAVGL
ECCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECCCHHHH
CAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIAERGAEAIQKIMAITNGYGADAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHE
ECVGTKEAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKE
EECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEECCCCHHHHHHHHHH
ILLEAVLSGEIDPGRVFTEEFTLDEIQKAYEAMDQRTAIKSLLIISEG
HHHHHHHCCCCCCCCEEHHHCCHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]