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The map label for this gene is msrA [H]

Identifier: 125623790

GI number: 125623790

Start: 918439

End: 918990

Strand: Reverse

Name: msrA [H]

Synonym: llmg_0951

Alternate gene names: 125623790

Gene position: 918990-918439 (Counterclockwise)

Preceding gene: 125623795

Following gene: 125623770

Centisome position: 36.33

GC content: 36.23

Gene sequence:

>552_bases
ATGAGTACAGAAAGAGCTATTTTTGCTGGTGGTTGTTTTTGGTGTATGGTTGAACCTTTCGAAGAACGTCCAGGTATTTT
GGCTGTAACAAGCGGCTATACAGGCGGACATATCGAATACCCTACTTATGACCAAGTTCTCTCAAAAGCTTCTGGCCATA
CAGAGGCCGTTGAAATTTTATTTGATAATGAACTGATTTCTTATGATGAGCTTTTAGATATTTATTGGTCTTTGATTGAC
CCAACGGATGCTGACGGTCAAATTTATGACCGAGGTGCAAATTACCGTCCAGTAATTTTTGTTGAAAGTGAAGAACAAAA
AACTGCTGCTAAAAAAAGTAAAATCGCCTTAGAAAAATCTGGAATTTGGGACAAACCAATAGTTGTTCCTATTGAAGAAG
CTAAAACTTTTTGGCCAGCTGAAGAATATCATCAACAATACTATAAAAAAGACCCTAAACGTTATCAAGCGATGCACAAG
GCACGTGAACGTTATTTGGCCTTACAACGTTTCAAAGGAAAATTTAAATTTTTAAGAAAAAACACTAGATAA

Upstream 100 bases:

>100_bases
ACAAAAAAGCCAAATTCAAAATTTTTAAAATTCGAGTCAAATGATGAGGCGGCATTTTTTTCACATGATATAATTAAATT
AGAGCAAATGGAGGTGTAAG

Downstream 100 bases:

>100_bases
GCTAGTGTTTTTATTTTATATTTGGCCAATCTTTTCCAAACCATTCTTGGTATAGATCTTCTACAATTTTAACAGTTGTC
ATTGTCATTTCAGGAGAAAG

Product: MsrA protein

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLID
PTDADGQIYDRGANYRPVIFVESEEQKTAAKKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHK
ARERYLALQRFKGKFKFLRKNTR

Sequences:

>Translated_183_residues
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLID
PTDADGQIYDRGANYRPVIFVESEEQKTAAKKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHK
ARERYLALQRFKGKFKFLRKNTR
>Mature_182_residues
STERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEILFDNELISYDELLDIYWSLIDP
TDADGQIYDRGANYRPVIFVESEEQKTAAKKSKIALEKSGIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKA
RERYLALQRFKGKFKFLRKNTR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.7358490566038, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.7358490566038, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=39.0909090909091, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=40.1315789473684, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=150, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=35.9154929577465, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=35.2112676056338, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=35.7664233576642, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 21291; Mature: 21160

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEIL
CCCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCEECCCCHHHHHHHCCCCCEEEEEE
FDNELISYDELLDIYWSLIDPTDADGQIYDRGANYRPVIFVESEEQKTAAKKSKIALEKS
ECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCC
GIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKARERYLALQRFKGKFKFLRK
CCCCCCEEEEHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTR
CCC
>Mature Secondary Structure 
STERAIFAGGCFWCMVEPFEERPGILAVTSGYTGGHIEYPTYDQVLSKASGHTEAVEIL
CCCCEEEECCEEEEEECCHHCCCCEEEEECCCCCCEECCCCHHHHHHHCCCCCEEEEEE
FDNELISYDELLDIYWSLIDPTDADGQIYDRGANYRPVIFVESEEQKTAAKKSKIALEKS
ECCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCC
GIWDKPIVVPIEEAKTFWPAEEYHQQYYKKDPKRYQAMHKARERYLALQRFKGKFKFLRK
CCCCCCEEEEHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NTR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]