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The map label for this gene is pyrP [H]

Identifier: 125623735

GI number: 125623735

Start: 861704

End: 862996

Strand: Direct

Name: pyrP [H]

Synonym: llmg_0891

Alternate gene names: 125623735

Gene position: 861704-862996 (Clockwise)

Preceding gene: 125623734

Following gene: 125623736

Centisome position: 34.07

GC content: 39.13

Gene sequence:

>1293_bases
GTGCACGATAATGATATTATCTTAAAAGTTGATGAGAAACCAGCTGCCAGTCAGTGGTTTGGACTCTCATTTCAACATTT
GTTTGCCATGTTTGGCTCAACGGTTTTAGTTCCGATTTTAGTTGGGATTAATCCAGCGATTGCCCTATTGAGTTCAGGAC
TTGGTACACTTGCACACATGAGTGTTACAAAATTTAAGGTTCCAGCTTACATGGGGTCAAGCTTTGCTTATATTGGTGCG
ATGACTTTACTGATGAAAAATGGCGGAATGCCAGCCATTGCCCAAGGAGCCATGACAGGTGGTCTGGTTTATCTGATTGT
CGCTCTGATTGTGAAATTTGCGGGTAAAGGTTGGATTGACAAAGTTTTACCACCAATCGTTGTTGGACCAATCGTTATGG
TTATTGGTTTATCCCTTGCGCCGACAGCAATTAATGATGCCATGTATACCGATGTTGCAAATCTAAAAGGATACAGTTTA
GCTTATATCATTATTGCCCTCATCACCGTTTTATCAATTGTCGTTTACAGTATTTATGGAAAAGGATTTCTGTCAGTCGT
TCCAATTTTACTCGGAATCATCACAGGTTATGTTGCAGCAATGATTATTGGTAAAATCACTGGCATGAATATCGTTTCCT
TTACGGGAATTTCACAAGCCAAATGGTTAACACTTCCACCAATGGAAATTCCATTTGCTAGCTATAAATGGGCTTTCTAT
CCGTCAGCAATCTTGACAATGGCACCCATTGCTTTTGTTACAATGACTGAACATTTTGGTCATATCATGGTCTTGAATTC
ATTAACAAAAAAAGATTATTTTAAAGAACCAGGACTTGAAAAAACGTTGACAGGGGATGGTTTAGCACAAATCATCGCCG
GCTTTATTGGTGCGCCACCGGTGACCTCTTATGGTGAAAATATCGGAGTCATGGCAATTACAAAAATTCATTCGATTTAT
GTGATTGCTGGCGCTGCGGTTCTTGCCATTGTTGTCTCATTTGTTGGCAAAATCACAGCTCTTTTACAATCAATTCCAGC
ACCAGTTATTGGTGGAGCATCAATTGCACTCTTTGGAGTTATTGCAGCCTCAGGTCTGAAAATTTTGGTTGAAAACAAAG
TTGATTTTGATATCAAGCGCAACTTATTGATTAGCTCAGTGGTCCTTGTTATCGGGATTGGTGGAATGATTATCAACATC
ACTCAAAACTTACAAATTTCATCAGTAGCTATTGCTACGATTCTCGGAATTGTCTTAAATCTTGTCTTACCAAAAGATGC
TAGCGAAATTTAA

Upstream 100 bases:

>100_bases
AGAAATAAGTTCTCTGTCAGTAATTTAAGAAAAAGAGTAATCTATAAGTTACTGACAAAGTTTTCAATAAATATTCAACT
TAGAGTTTTAGGAGAAAAAA

Downstream 100 bases:

>100_bases
ATATCTAAAAATTACTGACAGGACTGCCAGTTCAATGTGATGAATAATGAGCATTGAATCGGCGAATAAAAGATTCGTCA
GTTTACTGACAAAGCTGTCA

Product: uracil permease (Uracil transporter)

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVVYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISQAKWLTLPPMEIPFASYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFVGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVDFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDASEI

Sequences:

>Translated_430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVVYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISQAKWLTLPPMEIPFASYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFVGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVDFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDASEI
>Mature_430_residues
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHMSVTKFKVPAYMGSSFAYIGA
MTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWIDKVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSL
AYIIIALITVLSIVVYSIYGKGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISQAKWLTLPPMEIPFASYKWAFY
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPPVTSYGENIGVMAITKIHSIY
VIAGAAVLAIVVSFVGKITALLQSIPAPVIGGASIALFGVIAASGLKILVENKVDFDIKRNLLISSVVLVIGIGGMIINI
TQNLQISSVAIATILGIVLNLVLPKDASEI

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=459, Percent_Identity=24.6187363834423, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI44680143, Length=463, Percent_Identity=24.4060475161987, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1788843, Length=414, Percent_Identity=44.4444444444444, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI87081818, Length=430, Percent_Identity=36.2790697674419, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI87082181, Length=439, Percent_Identity=26.4236902050114, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790087, Length=470, Percent_Identity=23.1914893617021, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082178, Length=424, Percent_Identity=23.8207547169811, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=311, Percent_Identity=24.4372990353698, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45224; Mature: 45224

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHM
CCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHH
SVTKFKVPAYMGSSFAYIGAMTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWID
HHHHEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
KVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSLAYIIIALITVLSIVVYSIYG
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISQAKWLTLPPMEIPFASYKWAFY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCEEECC
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPP
HHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
VTSYGENIGVMAITKIHSIYVIAGAAVLAIVVSFVGKITALLQSIPAPVIGGASIALFGV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IAASGLKILVENKVDFDIKRNLLISSVVLVIGIGGMIINITQNLQISSVAIATILGIVLN
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHHHHHH
LVLPKDASEI
HHCCCCCCCC
>Mature Secondary Structure
MHDNDIILKVDEKPAASQWFGLSFQHLFAMFGSTVLVPILVGINPAIALLSSGLGTLAHM
CCCCCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHH
SVTKFKVPAYMGSSFAYIGAMTLLMKNGGMPAIAQGAMTGGLVYLIVALIVKFAGKGWID
HHHHEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
KVLPPIVVGPIVMVIGLSLAPTAINDAMYTDVANLKGYSLAYIIIALITVLSIVVYSIYG
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KGFLSVVPILLGIITGYVAAMIIGKITGMNIVSFTGISQAKWLTLPPMEIPFASYKWAFY
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCEEECC
PSAILTMAPIAFVTMTEHFGHIMVLNSLTKKDYFKEPGLEKTLTGDGLAQIIAGFIGAPP
HHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
VTSYGENIGVMAITKIHSIYVIAGAAVLAIVVSFVGKITALLQSIPAPVIGGASIALFGV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
IAASGLKILVENKVDFDIKRNLLISSVVLVIGIGGMIINITQNLQISSVAIATILGIVLN
HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHHHHHHH
LVLPKDASEI
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]