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The map label for this gene is gla [H]

Identifier: 125623714

GI number: 125623714

Start: 840113

End: 840976

Strand: Direct

Name: gla [H]

Synonym: llmg_0870

Alternate gene names: 125623714

Gene position: 840113-840976 (Clockwise)

Preceding gene: 125623713

Following gene: 125623715

Centisome position: 33.21

GC content: 41.32

Gene sequence:

>864_bases
ATGGATGTTTCATGGATGACAAAATATATTGCTGAGGGATTGGGAACTATGCTTCTCGTTTTGCTTGGTAATGGTACAAT
TGCGGGAGTAACACTCAAAGGCTCTAAAAATGAGGGCATGGGTGGCCTTGCAATCGCTTGGGGATACGGAATTGCGATTC
TAGTTCCTGTTCTTGCTTTTGCAAATGTTTCAGGGGCTCATATTAACCCAGCAATTACACTTGGACTTGCTTCAGCTGGT
CTATTCCCTTGGGCTCATGTTGCGCAATATATCTTGGCTCAACTTATTGGTGCAATTATTGGTCAGTTACTCGTCGTAGC
GATTTACAAAGAATACTTTGCTAAAACTAATGACGGAGCAATTTCTTTAGGCGCATTTGCCACAACTAACGCTTTGGATG
ATGGTTCAAATCGTGGAAAAGCAATTTTCAACGGTTTTGTCAATGAAGTAATCGGAATGTTTGTATTTGTTTTCGGAATT
CTCAGTTTTACAACGAACTTCTTTGGCTCAGAATCAATCAAATGGATGACAAGTTACGCTCAACAACAAGGTGCAGATAT
CACTTCTAGTGGTACACTTAGCCAAATTTGGGCTTCTGTTTCAGGCGCTTCATCATCTAAAATGGTTGGTGCCCTTGCCA
TTGGGTTAATGTTTGTTGGTTTGGTTACAGCATTTGGTGGACCAACTGGTGCAGCATTGAATCCAGCACGTGACCTTGGT
CCTCGTATTGTTTATAGCTTCTTGCCACAATCAGTTGTTGGTGAAAATAAAGACGCTAAATGGTGGTATGCTTGGGTTCC
AGTGGTTGCCACAATCGTTGGTGCAGTAATTGCAGCTACAGTATTTAAACTCATGTTTAAATAA

Upstream 100 bases:

>100_bases
TGTATTTTGCAATGTTATTATTAGCAAGAGTTAAGAAAAATATGATAAACTTATAGTGTCACATCTTTTATGTATTTTTA
AAAATAGAAAGGAAACTATC

Downstream 100 bases:

>100_bases
AATGAAAAAAATCTGTCTGATAGGCAGATTTTTTCTTGCCCTTAGAACTTAAAAGCGCTATAATGATTATAATTTACTGA
AAAGGACAGACAATTATGAC

Product: transporter

Products: glycerol [Cytoplasm] [C]

Alternate protein names: Aquaglyceroporin; Glyceroaquaporin [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDVSWMTKYIAEGLGTMLLVLLGNGTIAGVTLKGSKNEGMGGLAIAWGYGIAILVPVLAFANVSGAHINPAITLGLASAG
LFPWAHVAQYILAQLIGAIIGQLLVVAIYKEYFAKTNDGAISLGAFATTNALDDGSNRGKAIFNGFVNEVIGMFVFVFGI
LSFTTNFFGSESIKWMTSYAQQQGADITSSGTLSQIWASVSGASSSKMVGALAIGLMFVGLVTAFGGPTGAALNPARDLG
PRIVYSFLPQSVVGENKDAKWWYAWVPVVATIVGAVIAATVFKLMFK

Sequences:

>Translated_287_residues
MDVSWMTKYIAEGLGTMLLVLLGNGTIAGVTLKGSKNEGMGGLAIAWGYGIAILVPVLAFANVSGAHINPAITLGLASAG
LFPWAHVAQYILAQLIGAIIGQLLVVAIYKEYFAKTNDGAISLGAFATTNALDDGSNRGKAIFNGFVNEVIGMFVFVFGI
LSFTTNFFGSESIKWMTSYAQQQGADITSSGTLSQIWASVSGASSSKMVGALAIGLMFVGLVTAFGGPTGAALNPARDLG
PRIVYSFLPQSVVGENKDAKWWYAWVPVVATIVGAVIAATVFKLMFK
>Mature_287_residues
MDVSWMTKYIAEGLGTMLLVLLGNGTIAGVTLKGSKNEGMGGLAIAWGYGIAILVPVLAFANVSGAHINPAITLGLASAG
LFPWAHVAQYILAQLIGAIIGQLLVVAIYKEYFAKTNDGAISLGAFATTNALDDGSNRGKAIFNGFVNEVIGMFVFVFGI
LSFTTNFFGSESIKWMTSYAQQQGADITSSGTLSQIWASVSGASSSKMVGALAIGLMFVGLVTAFGGPTGAALNPARDLG
PRIVYSFLPQSVVGENKDAKWWYAWVPVVATIVGAVIAATVFKLMFK

Specific function: Mixed channel protein that transports both water and glycerol [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4826645, Length=282, Percent_Identity=28.0141843971631, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI22538420, Length=283, Percent_Identity=25.7950530035336, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI157266307, Length=301, Percent_Identity=26.578073089701, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790362, Length=276, Percent_Identity=26.8115942028986, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787101, Length=144, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17558372, Length=290, Percent_Identity=28.6206896551724, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17533613, Length=269, Percent_Identity=27.8810408921933, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32564052, Length=269, Percent_Identity=27.8810408921933, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531431, Length=276, Percent_Identity=29.7101449275362, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=286, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17531429, Length=276, Percent_Identity=29.7101449275362, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321054, Length=247, Percent_Identity=28.7449392712551, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 29979; Mature: 29979

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSWMTKYIAEGLGTMLLVLLGNGTIAGVTLKGSKNEGMGGLAIAWGYGIAILVPVLAF
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ANVSGAHINPAITLGLASAGLFPWAHVAQYILAQLIGAIIGQLLVVAIYKEYFAKTNDGA
HCCCCCCCCHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ISLGAFATTNALDDGSNRGKAIFNGFVNEVIGMFVFVFGILSFTTNFFGSESIKWMTSYA
EEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QQQGADITSSGTLSQIWASVSGASSSKMVGALAIGLMFVGLVTAFGGPTGAALNPARDLG
HHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
PRIVYSFLPQSVVGENKDAKWWYAWVPVVATIVGAVIAATVFKLMFK
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDVSWMTKYIAEGLGTMLLVLLGNGTIAGVTLKGSKNEGMGGLAIAWGYGIAILVPVLAF
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ANVSGAHINPAITLGLASAGLFPWAHVAQYILAQLIGAIIGQLLVVAIYKEYFAKTNDGA
HCCCCCCCCHHHEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ISLGAFATTNALDDGSNRGKAIFNGFVNEVIGMFVFVFGILSFTTNFFGSESIKWMTSYA
EEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QQQGADITSSGTLSQIWASVSGASSSKMVGALAIGLMFVGLVTAFGGPTGAALNPARDLG
HHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
PRIVYSFLPQSVVGENKDAKWWYAWVPVVATIVGAVIAATVFKLMFK
HHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]